Posted by admin on May 31, 2024 in |
Background & Objectives: Emblica officinalis Gaertn is a widely used medicinal plant with antidiabetic activity. This study was aimed to improve oral glucose tolerance, hepatoprotective and nephroprotective effect of linagliptin by given combination of aqueous fruit extract of Emblica officinalis on streptozotocin induced diabetic rats. Materials & Methods: Diabetes was produced on Wister albino rats by the intraperitoneal administration of streptozotocin (45 mg/kg BW). Linagliptin (5mg/70kg BW), E. officinalis (200 mg/kg BW) and fixed dose combination therapy of linagliptin (2.5 mg /70kg BW) with E. officinalis (100 mg/kg BW) were administered orally once daily for four weeks. Results: The result showed that both linagliptin and aqueous fruit extract of E. officinalis significantly increased oral glucose tolerance but combination therapy increased glucose utilization more significantly in comparison with linagliptin in glucose induced rats. Treatment with linagliptin and E. officinalis significantly restored liver function indices as measured by liver to body weight ratio, serum alanin transaminase, serum aspartate transaminase, serum alkaline phosphatase, serum Ɣ- glutamyl transferase, albumin and globulin and also...
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Posted by admin on May 31, 2024 in |
An increasing airflow limitation that is not entirely reversible is a hallmark of chronic obstructive pulmonary disease (COPD). In patients with COPD, the present study investigated the effectiveness and safety of formoterol/tiotropium bromide vs formoterol/glycopyrronium in fixed combinations. In conjunction with formoterol, the long-acting anti-muscarinic drug glycopyrrolate has recently received approval for the maintenance treatment of chronic obstructive pulmonary disease. Studies on the combination of long-acting beta 2 agonist and glycopyrrolate, particularly in patients from India, are scarce. Therefore, it was thought interesting to compare the safety and effectiveness of formoterol/tiotropium fixed dose combinations to formoterol/glycopyrrolate fixed dose combinations in GOLD Grade 3 COPD patients. In the COPD patients of GOLD Grade 3, the efficacy and safety of formoterol/glycopyrrolate and formoterol/tiotropium was studied. A total of 68 patients was assessed by using the Spirometry, the COPD Assessment Test score, and the Symptom score. The assessment of the effectiveness of treatment was done on days zero (before the therapeutic intervention) and at intervals of two weeks up to 12 weeks....
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Posted by admin on May 31, 2024 in |
Introduction: Antibiotics’ efficacy is declining over a period of time because of haphazard use in humans and animals. Empirical use of antibiotics and reduction in the new drug development strategies by pharmaceutical industry can lead to antibiotic resistance crisis in near future. Hence, identifying the common causative organism and their resistance pattern in the geographical region would be helpful in choosing appropriate antibiotics for the diseases. Methods: This retrospective study is done at GMERS Medical College and hospital, Junagadh, Gujarat, India. Bacterial isolates and antibiotic susceptibility data from May 2021 to May 2023 were studied from culture and sensitivity register maintained by the microbiology department. Data were analyzed by descriptive statistics. Results: Among 43 positive samples 62.8 % were male and 37.2 % were female. Major samples were of sputum 39.53% and urine 32.56%. Organisms identified were Klebsiella 37.2%, E. coli 30.2%, Pseudomonas 16.3%, Acinetobacter 4.65%, S. aureus 9.3% and Enterococcus 2.3%. E. coli (69 %) were resistant to ampicillin/sulbactam and co-trimoxazole. Klebsiella (75%) were resistant to tetracyclin and...
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Posted by admin on May 31, 2024 in |
It belongs to the group of medications called as anti-metabolites and is a fluoropyrimidine carbonate with anti-cancer properties. The chemotherapy drug capecitabine is taken orally and is used to treat metastatic colorectal and breast cancers. A review of the literature reveals several analytical techniques have been developed for Capecitabinein single and combined with other drugs. No QbD-assisted RP-HPLC method is available to estimate Capecitabine. So, present work describes the development and validation of QbD driven RP-HPLC method for Capecitabine. This method has been developed using Agilent 1100 series HPLC with ODS (water) column (150 × 4.5mm, 5 µm). Based on the RP-HPLC method development Mobile phase and Flow rate were selected as CAA and retention time, peak area, theoretical plates, tailing factor of drug were monitored using Design Expert 13.0.0.5. By applying CCD, 8 trials having 2 factors and 4 responses method had been selected for method development of capecitabine. The optimum method development was selected based on the criteria of Retention time, Peak area, Theoretical plates, Tailing factor....
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Posted by admin on May 31, 2024 in |
Glinus oppositifolius (L) is a medicinal plant as well as edible leafy vegetables that has long been utilized for its therapeutic effects. The goal of this work is to use Atomic Absorption Spectroscopy to determine trace elements in Glinus oppositifolius (L). Acid digestion was used as a flexible method and all elements were determined using Atomic Absorption Spectroscopy. Calibration curves were created using standard solutions. The average concentration of the elements, expressed as mg/kg dry weight of the sample, were found to be 205.55mg/kg for Zn, 113.7mg/kg for Mn, 3.75mg/kg for Cr and 78.8mg/kg for Ca. Among the analysed elements, maximum amount of trace elements was Zn followed by Mn, Ca, and Cr. This study sheds light on that the Glinus oppositifolius (L) plants potential nutritional and health-related benefits through their high trace element content present. Trace element levels are being monitored and managed. Moreover, it showed that the AAS method is a simple, fast, and reliable for the determination of elements in plant materials. The obtained results of...
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