Posted by admin on Feb 29, 2024 in |
Medication Adherence is defined as “the extent to which a person’s behavior in taking medication, lifestyle management, diet, corresponding with an agreed recommendation from a healthcare provider”. Hypertension also called high blood pressure is defined as persistency with an elevation in systolic blood pressure ≥140 mmHg and /or diastolic pressure ≥ 90 mmHg. A cross-sectional study was carried out in order to measure medication adherence, Morisky Green Levine-Medication Adherence Questionnaire developed by Donald Morisky was used to assess medication adherence assessment, which consists of 4 questions (items) whose wording questions are formulated to avoid answering ‘yes’ or ‘no’ and three levels of medication adherence: high, medium, and low were measured based on the scores 0, 1-2,3-4 respectively. The study carried out an evaluation of medication adherence among hypertensive patients. Among 245 respondents, 5.7% were found to be highly adherent, 37.6% were found to be medium adherent and 56.7% were found to be low adherent. A significant association between a family history of hypertension, diabetes, and smoking behavior was observed....
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Posted by admin on Feb 29, 2024 in |
C. splendens is a medicinal plant used for various ailments within the West-African Community. This study sought to investigate the pharmacognostic characteristics, mycobactericidal, and mutagenic activities of the hydro-ethanolic leaves extract C. splendens. The organoleptic, microscopic, macroscopic and physicochemical characteristics were investigated according to WHO, 2011 quality control methods for herbal materials. The mycobactericidal and mutagenic activities were investigated by the agar well diffusion assay and the Ames test (Muta-ChromoPlateTM) respectively. Present in C. splendens are tannins, flavonoids, glycosides, saponins, steroids and alkaloids which are comparable to published literature. The leaves of had anomocytic stomata, and starch granules, while calcium oxalate crystals were visibly absent. The 50% ethanol extract of C. splendens was not active against M. smegmatis at the highest concentration of 100 mg/mL. C. splendens was also non-mutagenic. Though the extract exhibited no mycobactericidal activity at the highest tested concentration, the documented pharmacognostic characteristics can be used for the purposes of authentication. Also, the non-mutagenic potential indicates a lack of toxicity in that...
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Posted by admin on Feb 29, 2024 in |
Aspartame is the most common artificial sweetener which is known to induce oxidative stress. Our goal was to determine whether Boeravinone B and Chebulinic acid protect HepG2 cells against Asp-induced oxidative stress in HepG2 on a multifarious level. In this investigation we have addressed ameliorative role of BB and CA in due course of Asp exposure by evaluating biochemical and molecular parameters. We found that Aspartame induced oxidative stress in HepG2 cells through elevation of ROS and RNS which was further attenuated by BB and CA. Associated levels of SOD, CAT, GPx, Protein carbonyls, Lipid peroxides and Caspase 3/7 in Asp treated cells were found to be risen but BB and CA supplementation restored these back to normal. It was revealed from fluorescence microscopy as well as flow cytometric analysis that BB and CA reversed the proportion of apoptotic, necrotic as well as autophagic cells which was found to be triggered during Asp exposure. mRNA expression of marker genes associated with Apoptosis, Necrosis and Autophagy was observed to be...
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Posted by admin on Feb 29, 2024 in |
Changes in drug prescribing-pattern in different groups of population and age-related pathophysiological changes may result in altered response of drugs and need proper monitoring to avoid adverse consequences. Polypharmacy is very common in elderly which further increases risk for unwanted effects. Moreover, physicians should be more familiar with the common problems and diseases occurring amongst elderly population and the drugs safe for this age group. Present study has been done to know the pattern of diseases occurring amongst elderly and commonly prescribed drugs for this population. Study-design was cross-sectional and it included private medical practitioners at Lucknow. Patients above 60 years of age attending these physicians were interviewed personally using a questionnaire. Thus, this study describes pattern of medication consumption by elderly patients among community dwelling in urban and rural areas of Lucknow. Out of 112 subjects interviewed, 51.5% elderly were prescribed three or more medications. Overall consumption varied from 1 to 10 different medications per day. Out of all medications prescribed; antihypertensives ranked first followed by analgesics, sedative-hypnotics,...
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Posted by admin on Feb 29, 2024 in |
The advancement of drug therapy has undoubtedly elevated patient care standards. However, it has also given rise to an increase in Drug-Related Problems (DRPs), which can significantly disrupt health outcomes. In an 18-month prospective observational study involving 2,000 patients, we meticulously assessed DRPs using the Hepler and Strand classification system. These DRPs encompassed a range of issues, including adverse drug reactions (ADRs), untreated medical indications, non-compliance with prescribed regimens, improper drug selection, and more. Our data collection adhered to a well-validated and pre-tested format. Among 2,000 patients, 106 (5.3%) experienced 117 DRPs, averaging 1.1 per patient. Adverse drug reactions (ADRs) accounted for 47.01% of cases, non-compliance 35.89%, and drug use without indication 11.32%. ADR incidence was 2.75%, primarily affecting the Gastrointestinal (GIT) system. Antibiotics were frequently associated with ADRs in various drug classes. Vigilant monitoring, robust reporting mechanisms, and patient education are pivotal strategies in the prevention of drug-related issues. Pharmacovigilance, the systematic monitoring and evaluation of drug safety and efficacy, plays a fundamental role in ensuring the delivery...
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