Posted by admin on Jul 31, 2017 in |
A new series of Cu(II), Zn(II) and Co(II) complexes have been synthesized from 6-Methoxy-3-phenyliminomethyl-chromen-4-one, a Schiff base derived from 6-Methoxy-4-oxo-4H-chromene-3-carbaldehyde and aniline. The nature of bonding and the structure of the complexes have been deduced from IR, UV, 1H NMR spectroscopy. The biological activity of the ligand and metal complexes have been examined against both gram-positive as well as gram-negative bacteria by the Agar well method using DMSO as solvent and Gentamicin as standard drug. The zone of inhibition values and MIC were measured at 37 ºC for 24 h. Antimicrobial screening tests displayed better results for the metal complexes as compared to the...
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Posted by admin on Jul 31, 2017 in |
The aim of the present study is to screen the phytochemicals present in the leaf extract of Kandelia candel and further analysis of the bioactive components present in it by Gas chromatography – Mass spectrometry (GC-MS) analysis. Carbohydrates, proteins, amino acids, Saponins, flavonoids, terpenoids, glycosides, tannins, alkaloids, and phenols were present in the sample. The percentage yield of plant extract is high in ethanol extract and is 7.02%. GC-MS analysis of chloroform extract of K.candel leaf extract revealed the presence of 16 compounds and Longipinene epoxide(peak area 25.12) and 2-C14H26 (peak area 25.12)were the major compounds. The compounds were identified by comparing their retention time, peak area and by interpretation of mass spectra and matched with the National Institute of Standards and Technology (NIST)...
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Posted by admin on Jul 31, 2017 in |
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, followed by stem, primarily by aqueous and methanolic extracts. The methanol and ethyl acetate extracts from all four plant parts showed decent antioxidant activities against DPPH free radicals, with methanolic extract of N. arbor-tristis stem showed activity as 86.9%, higher than the positive control. All the ethyl acetate extracts showed moderate to good activity (50-65%), showing that all the four plant parts have decent antioxidant potential. Further, the scavenging of the peroxide free radicals, produced during lipid per oxidation was also investigated. The methanolic extracts of flower and root, and ethyl acetate extract of stem showed almost 80% activity. The aqueous extract of leaf showed very good peroxide scavenging activity. The hexane extract...
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Posted by admin on Jul 31, 2017 in |
The present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle – amine and 1, 4-dioxane. The synthesized compounds were characterized by FT-IR, 1H NMR spectra and elemental analysis and were screened in-vitro against three bacterial strains namely Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and two fungal strains namely Aspergillus niger, Aspergillus flavus by disc diffusion method. The compounds exhibited good antimicrobial activity....
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Posted by admin on Jul 31, 2017 in |
The lanthanide (III) complexes of general formula of [Ln(FPNH)2(NO3)](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; FPNH = 2-formylpyridine nicotinoylhydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that FPNH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridine nitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is...
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