Posted by admin on Apr 30, 2017 in |
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum, Phyllanthus emblicus extract and silymarin remarkably showed the hepatoprotective effect in the albino mice. Administration of C. cyminum, P. emblica and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of Total protein content. It also increased the level of antioxidant enzymes in the liver of mice showing its hepatoprotective activity. We found C. cyminum has a better hepatoprotective effect than P....
Read More
Posted by admin on Apr 30, 2017 in |
The present study was planned with the aim to remove various dye decolorization using fungal strains. The fungi was isolated from soil samples collected from waste disposal areas and agricultural fields. Nine isolates were initially selected for testing their decolorization potential in the liquid medium. Three most effective strains were used to study the decolorization of four different dyes i.e Reactive Red, Navy Blue HER, Reactive Magenta B and Orange 3R. The strain belonging to Talaromyces funiculosum (M2F) was found to be the most potent strain. More than 70% decolorization was observed under optimal incubation conditions of temperature and pH. Overall, the dye decolorization was maximum at 250 mg/L dye concentrations at pH 5-6 under continuous shaking conditions. The culture conditions like pH, temperature, inoculum size and NaCl concentrations were also found effective in decolorization efficacy of the fungal strain which was studied using Response surface methodology (RSM) with Minitab 16 software. Qualitative and quantitative assays for determining the production of lignolytic enzymes such as laccases and peroxidises by...
Read More
Posted by admin on Apr 30, 2017 in |
Pharmacovigilance can be helpful in defending consumers from harmful effects of medicines. Pharmacists should consider Adverse Drug Reaction (ADR) reporting as their professional obligation and should be aware of the existing pharmacovigilance mechanisms in their countries. Purpose: The present study evaluated the knowledge, attitude and practices (KAP) of the pharmacists towards ADRs and pharmacovigilance in Basra Hospitals. Methods: A cross-sectional analytical study was carried out in the province of Basra. All the pharmacists present in the Basra province during the study period were enrolled in the study and the convenience sampling technique was utilized for analysis. Hence, 530 pharmacists took part in the study. This questionnaire was tested and made error-free prior to using. This questionnaire contained 5 knowledge-based questions, 5-attitude related questions and tow questions which were related to the practices used towards the ADRs. Results: The response rate was 24.9 %.The results of our study clearly point out that in spite of the pharmacists positive attitude there was a lack of appropriate knowledge and practice to implement...
Read More
Posted by admin on Apr 30, 2017 in |
Leprosy is a chronic granulomatous disease caused by acid-fast bacilli Mycobacterium leprae. It is most prevalent in tropical countries and poses a threat to over 122 countries across the globe. In 2012, 232857 new cases of leprosy were registered in the world. World Health Organization (WHO), recommended the Multi Drug Therapy (MDT) for treatment of leprosy, but the minimum duration of treatment ranges from 6-12 months. Therefore, the need of a new putative target for treatment of leprosy, which is effective in leprosy and reduces the duration of treatment. The Proteome information available suggests that among the 1603 proteins in M. leprae TN, a staggering 27% or more remains classified as hypothetical uncharacterized set of proteins. In this present work we, assign the probable functions of hypothetical set of proteins present in M. leprae to explore their plausible role as new putative drug targets. Out of 442,177 hypothetical protein sequences had GO term. Of these, 43 sequences had disease ontology (DO) term, 59 sequences had human phenotype (HP) term...
Read More
Posted by admin on Apr 30, 2017 in |
In this study, a novel series of heterocyclic compounds containing pyrazolidine-3, 5-dione nucleus has been synthesized. The compounds were synthesized in four steps; esterification of 2-mercaptobenzoic acid in an acidic medium to yield 2-mercapto-benzoic acid ethyl ester which was cyclized using ethyl acetoacetate to form 2-methyl-4-oxo-4H-thiochromene-8-carboxylic acid ethyl ester. These were reacted phenyl hydrazine derivatives to give corresponding thiochromene derivatives, which were cyclized using diethylmalonate to obtain pyrazolidine-3, 5-dione derivatives. All the synthesized compounds were characterized by spectral (IR, NMR and MS) and elemental analysis. The compounds were screened for their antibacterial activity against Gram-positive bacteria (B. subtilis, S. epidermidis, M. luteus, S. aureus, B. pumilis, and B. cereus), Gram-negative bacteria (K. pneumonia, E. coli, and P. aeroginosa) and for antifungal activity against (A. niger, C. albicans and F. solani) by agar-diffusion method. The minimum inhibitory concentrations (MICs) of these compounds were also determined by tube dilution method. The antimicrobial effectiveness of all the compounds was found to be concentration dependent. Two compounds- 1-(3-chlorophenyl)-2-(2-methyl-4-oxo-4H-thiochromene-8- carbonyl) pyrazolidine-3, 5-dione (5a) and...
Read More
