Posted by admin on Jul 31, 2017 in |
Porphyrins are ever-present large class of naturally occurring macrocyclic compounds with many significant biological representatives comprising heme and chlorophyll. Novel bi-metallic porphyrins derived from [5-(4-hydroxyphenyl)-10,15,20-tri(4-methyl phenyl) porphyrin] and salicylideneamino-2-(N,N-dimethylamino) ethane copper (II) perchlorate was obtained in good yields. The results from various physico-chemical studies reveal a change in the geometry of the copper environment after coordination at the periphery of the porphyrin. The EPR of monocuperated metalloporphyrins have signals of copper with planar geometry and lacks the lines corresponding to peripheral metal due to dipolar broadening. Weak interaction between the metal centers is clear from nickel...
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Posted by admin on Jul 31, 2017 in |
Objective: The present study was conducted to assess the incidence, causality and severity of diuretic induced Adverse Drug Reactions (ADRs). Method: 92 patients admitted in the intensive cardiac care unit and prescribed with diuretics were included and data on demographics, past medical and medication history, allergies to food/drugs, laboratory parameters, diuretics prescribed, side effects and ADRs were obtained. The causality of ADRs was assessed using Naranjo’s and WHO’s a causality assessment scale, the severity of ADRs using Hartwig and Siegel’s scale. Results: 41 (44.6%) patients were prescribed with one diuretic, 38(41.3%) with 2 diuretics and 13 (14.1%) with 3 diuretics. 54 patients were prescribed with loop diuretics, a combination of loop and potassium sparing diuretics were given for32 patients; loop and thiazides for 5 and a potassium sparing diuretic for one patient. Of 40 (44%) patients with ADRs, 32 had one ADR, 7 had two ADRs and one patient had three ADRs. Naranjo’s scale identified 25 ADRs as probable, 15 as Possible and none as unlikely or certain; WHO...
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Posted by admin on Jul 31, 2017 in |
Protein conformation and dynamics are influenced by various factors, including binding of ligands, their physico-chemical properties, etc. Every conformational change is dictated by an array of events, as making and breaking of bonds or change in interaction of protein residues. The three dimensional structure of protein molecules are widely investigated, based on small world network approaches, with an emphasis on different combinations of descriptors affecting the structure which have been tested on studies involving binding in protein ligand complexes and for protein-protein complexes. This application has revealed the benefits and success of the small world network approach which can change the focus from specific interactions in the local environment or to non-local phenomenon. Network analysis of interacting protein upon ligand binding is analysed. A similarity in interaction parameters among residues of the target protein, upon binding of particular ligands, is identified. This method differentiates ligands, on the basis of overall changes in interaction among residues of Target proteins in...
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Posted by admin on Jul 31, 2017 in |
Microalgae have been widely used as novel source of bioactive substances. These substances exhibit various biological actions including, antioxidant, antimicrobial, antiviral, antitumoral, anti-inflammatory and anti-allergy effects. In the present investigation algal biomass in methanol extracts of chlorophyceae member of three micro algae of Chlorella vulgaris, Desmococcus olivaceous and Chlorococcum humicola was screened. The antioxidant property of the methanolic extracts of these green microalgae was evaluated by measuring the free radical scavenging activity by DPPH assay method. The algal extracts were then evaluated for their suppressive effect on tumor cell growth (MCF7) by using MTT assay and further analysed using GC-MS to determine the profile of specific molecules or compounds. Antioxidant activities of the microalgal methanol extracts were studied by their ability to scavenge DPPH at various concentrations. The DPPH radical scavenging activity was found to be higher in Chlorella vulgaris (RSA 53.96%) at a concentration 20μg compared to standard ascorbic acid (RSA 59.42%). Anticancer property of the methanol extracts of Chlorella vulgaris, Desmococcus olivaceous and Chlorococcum humicola in MCF7...
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Posted by admin on Jul 31, 2017 in |
Present paper reports the chemical constituents in the fatty acids obtained from the whole plant of diploid and tetraploid Physalis angulata Linn. collected from hot desert areas of Rajasthan. The fatty acid analysis was carried out by gas chromatography-flame ionization detector (GC-FID). Meiotic studies confirm the ploidy level of the plant. Diploid (n = 12) cytotype is reported from Udaipur district and tetraploid (n = 24) cytotype from Sri Ganganagar. There is a considerable difference in the fatty acid constituents in the cytotypes. Major constituents of fatty acids are Oleic acid (24.93%, 2x; 18.71%, 4x); capric acid (13.4%, 2x; 0.14%, 4x); Palmitic acid (6.966%, 2x; 12.38%, 4x); Linoleic acid (5.5%, 2x; 9.76%, 4x) and Linolenic acid (6%, 2x; 11.67%, 4x). The main objective of the object work was to compare the fatty acid composition within two cytotypes. Such analysis of plants is very important on commercial level for the productions of cosmetic and has great interest in pharmaceutical companies for the production of...
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