Posted by admin on Apr 30, 2017 in |
Acinetobacter baumanniiis typically coccobacillus Gram-Negative bacterium, resists almost all antibiotics in use. Synthetic antimicrobial peptides (AMPs) against this bacterium were designed with the aid of computational software and databases to be with the accepted models. Antimicrobial peptides (AMPs) might be the candidate solution for the this problems. Four peptides designated MY1, MY2, MY3 and MY4 were synthesized with length 11-14 amino acids, they were rich in Arginine and Tryptophan. The MICs of the peptides against colistin sensitive A. baumannii were 2.4, 6.2, 6.9, 6.6 µg/ml (mean for 10 strains) respectively vs Mastoparan as control was 10.4 µg/ml, whereas the MICs of peptides against colistin resistant A. baumannii were 3.8, 6.2, 6.8, 6.4 µg/ml (mean for 10 strains) respectively vs Mastoparan 13.6 µg/ml. The designed peptides showed no hemolytic activity at effective MICs. The practical calculated Therapeutic Index were 141.7, 67.7, 60.9, 77.3 vs 7.7 for Mastoparan (Colistin sensitive strains) and for resistant strains were 89.5, 67.7, 61.8, 79.7 vs Mastoparan...
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Posted by admin on Apr 30, 2017 in |
The number of medical applications for natural or synthetic biomaterials contin\ues to expand. One particularly interesting development concerns the use of injectable polymeric biomaterials. The forms in which the biomaterials are injected can vary from particulate matter, e.g., microspheres or irregularly shaped particles, to gels and cements that are injected in liquid form and which harden inside the body. Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. The development of using polymer combination have attracted much attention because the biodegradation rate of the copolymer is easily controlled by altering its composition. In this review, the fundamental drug delivery systems from polymer blends including the origins and applications of polymer blend systems and polymer blend therapeutics are highlighted. The PCL microparticle-dispersed PLGA solution may be a good candidate as an injectable bulking agent. Using PCL–PLGA blend, the porous structure of the...
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Posted by admin on Apr 30, 2017 in |
Pterocarpus marsupium Roxb. (Fabaceae) is a moderate to large deciduous tree, belonging to family Fabaceae. It is considered as an extremely useful source of unique natural products for development of medicines against various diseases and for industrial product development. The present study includes physicochemical parameters like ash value, extractive value, fluorescence analysis, moisture content and preliminary phytochemical screening along with mineral analysis. Antimicrobial activity was also assessed for this plant. The physicochemical constants obtained were within normal levels prescribed by standards. The phytochemical studies revealed the presence of primary and secondary metabolites in various solvent extracts of Pterocarpus marsupium bark. The estimated mineral composition was in good amounts which would serve as a device for deciding dosage of ayurvedic drug prepared from the plant. Antimicrobial activity by disc diffusion method indicated the zone of inhibition which ranges from 11-22mm for different extracts. Further evaluation of test samples for minimum inhibitory concentration (MIC) using micro dilution method showed that the methanol extract had exhibited significant activity by inhibiting S.typhi, E.faecalis...
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Posted by admin on Apr 30, 2017 in |
The objective of the study was to determine the cost effective drug among oral hypoglycemic agents utilized in a multispeciality hospital to treat type-2 diabetes mellitus. The prospective cost effectiveness study was conducted for 6 months period in patients who were diagnosed with type-2 diabetes mellitus and were receiving treatment specifically with oral hypoglycemic agent(s). The data obtained was introduced to Incremental Cost Effectiveness Ratio determination to arrive at the most cost effective drug and the prescription pattern and drug related problems in the patients were monitored. A total of 141 patients were included in the study. Glipizide among monotherapy (p<0.01), Glimepiride as add on therapy to Metformin (p<0.001), fixed dose triple combination of Glimepiride, Pioglitazone and Metformin (p<0.01) and fixed dose combination of Glimepiride and Metformin (p<0.001) were found to be more effective using statistical analysis. Most of the patients were receiving fixed dose combinations (43.6%) out of which Glimepiride and Metformin combination (34.42%) was predominant over the others. Serious drug interactions (12) and adverse drug reactions (5)...
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Posted by admin on Apr 30, 2017 in |
Introduction: Self Medication (SM), a form of self care, is a topic of growing interest among researchers and a matter of concern for policy makers and implementors, owing to a plethora of associated malpractices in general population. There is paucity of information about this menace, especially in developing countries. The objective of the present study was to assess the prevalence, pattern and determinants of self medication among adult residents of a district in North India. Methods: This community based cross sectional mixed method study was carried out in of a district S.A.S, Nagar, Mohali, Punjab, India. Multistage stratified random sampling technique and Probability proportional to size (PPS) was used in the 400 households from urban, rural and slum areas. A pretested questionnaire was administered to one representative member of each of the 400 households. Besides 150 people visiting medical stores were interviewed for self medication practices. Results: SM was widely practiced (97%) in study population, more in urban as compared to rural and slum counterparts. People of all socio...
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