Posted by admin on Apr 30, 2017 in |
Background: Hyperglycemia may induce endothelial dysfunction. Chromium Supplementation enhances endothelial relaxation and may improve endothelial dysfunction. Present study was planned to evaluate effect of proprietary chromium complex(PPC) and its individual components on endothelial dysfunction and lipid profile in type 2diabetics. Methodology: Study was done in two parts. In part I, PPC 400mcg produced significant improvement in endothelial function compared to PPC 200mcg and placebo. In part II, 96 eligible subjects were randomized to chromium chloride 400mcg, Phyllanthus emblica 6mg and Shilajit 6mg, chromium picolinate 400mcg, chromium polynicotinate 400mcg and chromium dinicocysteinate 400mcg and compared to PPC 400mcg. Efficacy parameters were change in endothelial function(>6% change in reflection index(RI), biomarkers of oxidative stress and lipid profile after 12weeks treatment. Laboratory safety parameters were measured at baseline and post treatment. Results: Total 96 subjects completed the study. PPC 400mcg produced better improvement in reflection index (−3.34%±1.00% to −7.23%±1.88% (p<0.001) compared to chromium chloride 400mcg (-3.79%±0.82 to-3.22%±0.85), Phyllanthus emblica 6mg and Shilajit 6mg (-1.44%±0.58 to-5.67%±0.54), chromium picolinate 400mcg (-4.68%±1.24 to -2.46%±0.90), chromium...
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Posted by admin on Apr 30, 2017 in |
The multidrug-resistant strains are a major problem in the control of infections in hospitals. The smaller size of nanoparticles is gaining importance in research for the treatment of various diseases. The main objective of this study is synthesis of silver nanoparticle in eco-friendly manner without using any hazardous chemicals. Stable and spherical shaped nanoparticles Synthesized by using aqueous leaf extract of T. alata. This method offers a viable and an eco-friendly way for fabrication of benign nanoparticles as it is a simple and carried out at room temperature without any huge inputs in terms of energy and waste. It is advantageous over the microbial synthesis as it is carried out using in aqueous solutions at ambient temperature, without any toxic chemicals in lesser time and could be exploited for developing cost effective biosynthesis of Ag nanoparticles at a large scale. One more aim of this study is that analysis of antimicrobial activity of biogenic nanoparticles against disease causing human pathogens. Characterizations of nanoparticles were done by UV-Vis spectroscopy, FTIR,...
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Posted by admin on Apr 30, 2017 in |
Sumatriptan succinate, a selective 5-hydroxytryptamine-1 receptor agonist, is an antimigraine drug with bitter-taste. The present study was performed to prepare and evaluate eudragit-E microparticles containing sumatriptan and formulate fast disintegrating tablets of drug microparticles to increase patient-compliance and improve the efficacy of drug. Microparticles were prepared by solvent-evaporation method using water-dichloromethane/PVA and water-dichloromethane/liquid paraffin systems. The effect of different variables (polymer:drug ratio, PVA concentration and solvents combination ratios) on particle size and encapsulation efficiency of the microparticles was investigated. The final microparticles were evaluated for particle size, loading percent, taste-masking, thermal analysis and in-vitro release profile. The drug loading were higher in w/o/o emulsion than w/o/w. Mean particle size was not statistically different for different formulations. Sumatriptan release rate from eudragit-E microparticles was very fast in HCl 0.1 N medium and release profile was acceptable for fast disintegrating tablets. The prepared tablets were evaluated for in-vitro disintegration time, weight variation, hardness, friability and in-vitro drug release. The optimized formulation (F6) (provided a pleasant taste and mouth-feel) disintegrated within 20...
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Posted by admin on Apr 30, 2017 in |
Aims and objectives: Periodontal disease is the most common disease associated with microbial infection with destruction of supporting structures. The aim of the present study is compare the antimicrobial efficacy of plants of lythraceae family with hiora mouthwash in subjects with chronic periodontitis. Materials and methods: A total of 90 subjects were taken and randomly divided into three groups with 30 each. Group 1 received punica mouthwash, group 2 with lawsone mouth wash and group3 hiora mouth wash. Oral rinse technique was performed. Total microbial load and specific aerobic and anaerobic bacteria like Streptococci, staphylococci species, Agregatibacter actinomycetemcomitans, and Porphyromonas gingivalis were determined. Subjects were instructed to use given mouth washes twice daily with volume of 5ml/rinse for 30 sec and later post therapeutic samples were collected 1hr and 1week following drug usage and they were evaluated for total microbial load. Results: Statistical analysis was performed using chi square and one way ANOVA. All the three groups were compared at different time intervals which showed significant difference (P=0.000*) in...
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Posted by admin on Apr 30, 2017 in |
The prime aim and object of present investigation is to develop and validate a novel, precise, accurate, specific, rapid and economic stability- indicating isocratic reverse phase liquid chromatography method for the quantitative simultaneous estimation of Tenofovir disoproxil fumarate and Emtricitabine in bulk and marketed formulations. Estimation of drugs in this combination was achieved with a C18 column [Agilent TC-C18 (2) column. 5mm, 4.6´250 mm]kept at ambient temperature, using mobile phase of composition Methanol and phosphate buffer (30:70 v/v, pH 4).The flow rate was 1.0 ml/min and the effluents were monitored at 261 nm, using variable wavelength UV detector. The retention time of Tenofovir disoproxil fumarate and Emtricitabine were 2.81min and 4.72min respectively. Validation of the method was done according to the ICH guidelines for different analytical parameters. The method was found to be linear over a range of 40-80mg/ml for Tenofovir disoproxil fumarate and Emtricitabine. The established method proved as reproducible one with a %RSD value of less than 2 and having the robustness and accuracy within the specified...
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