Posted by admin on Mar 31, 2017 in |
Coronary heart disease (CHD) is widely prevalent both in the developed and developing countries and continues to be a leading cause of mortality despite recent advances in diagnostic facilities and treatment modalities. Recently it has been proposed that postprandial lipoprotein may be a better indicators of deranged lipoproteins metabolism and hence of atherosclerosis and CHD. The levels of non-fasting triglycerides are better at predicting future cardiovascular events than levels of fasting triglycerides. Furthermore, it is possible that non-fasting levels of lipids, lipoprotein, differ only minimally from levels in the fasting state simply because, most of the people consume for less fat at ordinary meals than during a fat tolerance test. The aim of the current study is to determine the postprandial (at the intervals of 2 hours and 4 hours) lipid parameters TC, TGL, HDL, LDL and VLDL levels in Coronary heart disease patients and to compare it with fasting lipid profile. 200 subjects were selected with 100 controls and 100 CHD cases. Statistical analysis was done. The study...
Read More
Posted by admin on Mar 31, 2017 in |
Diabetes is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased responsiveness of the organs to secreted insulin. The protective effect of aqueous extract of Plumeria Rubra was studied against streptozotocin (STZ) induced diabetes in rats. Plumeria rubra was administered orally at 3 dose levels (100, 200, 400mg/kg). Plumeria rubra extract and standard drug Glibenclamide (GB) (10mg/kg, p.o.) was administered to animals for 28 days. The blood glucose, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein, body weight were assessed in the experimental animals. Plumeria rubra extract induced significant reduction (P < 0.001) in blood glucose levels in STZ induced diabetic rats. Plumeria rubra was found effective at all doses, although 200 mg/kg was found to be more effective and comparable with standard group. Additionally, histopathological examination of kidneys and pancreas showed that Plumeria rubra markedly ameliorated STZ induced renal tubular necrosis and pancreatic damage. Plumeria rubra exhibited significant antihyperglycemic activity in STZ induced diabetic rats. The results of the present...
Read More
Posted by admin on Mar 31, 2017 in |
The pH/temperature sensitive microcapsules were prepared by inverse emulsion polymerization, in which sodium alginate (SA) and N-isopropyl acrylamide (NIPAm) were used as the wall material and pentoxifylline as a model drug. The effects of the emulsifier content on the particle size distribution and drug release property of microcapsules were discussed in detail. The structure, morphology, particle size and its distribution of microcapsules were characterized by Fourier transform infrared spectrophotometry (FTIR), scanning electron microscopy (SEM), transmission electron microscope (TEM), Malvern particle size analysis and UV-vis spectrophotometer. The release behavious of pentoxifylline in different phosphate buffered saline (PBS) pH were investigated systematically. The results showed that the resultant microcapsules had narrower particle size distribution, smoother surface and higher drug release amount with the percentage weight of emulsifier being 2.0%. The TEM photograph exhibited that the microcapsules had core and shell structures. The drug-release behavior of pentoxifylline from microcapsules was evaluated as a function of pH/temperature. The results indicated that these drug-loaded microcapsules have shown sensitivity to pH value and...
Read More
Posted by admin on Mar 31, 2017 in |
Norepinephrine (NE) is an important catecholamine neurotransmitter that acts as a biochemical messenger in central nervous systems and neuronal cells of mammals, which is secreted and released by the adrenal medulla and the noradrenergic neurons during the synaptic transmission. It is often used for treating bronchial asthma, myocardial infarction hypertension and organic heart disease. Abnormal release of NE will contribute to the occurrence of many nerve related diseases, such as paraganglioma, ganglia neuroblastoma, ganglion neuronal, and Parkinson’s disease. In addition, increased NE concentration in plasma is associated with coronary heart disease and with muscle sympathetic nerve traffic in human obesity. Furthermore, NE is involved in the occurrence and development of cardiac hypertrophy through the activation of myocardial adrenergic receptors on cell membranes in myocardial tissue. Therefore, the rapid, sensitive, and selective detection of NE level is significant for monitoring physiological function and diagnosing diseases. In this article the studies of detection methods for NE in recent years are...
Read More
Posted by admin on Mar 31, 2017 in |
Among adults in India, Chronic myeloid leukemia (CML) is most common leukemia and accounts for 30% to 60% of all adult leukemias. Imatinib mesylate induces the highest rate of complete hematological and cytogenetic responses, but its efficacy is still debated in different sets of patients. Total 50 newly diagnosed patients of CML were enrolled. Patients receiving imatinib 400mg orally daily were monitored carefully for haematological changes and changes were noted at 3, 6 and 9 month. Patients were categorized on the basis of age and gender, and hematological and cytogenetic responses were compared. Cytogenetic studies were done at 6 months to ascertain the response. Imatinib produced >80% response in various hematological parameters in different groups of patients. Younger age group and male patients shows better hematological as well as cytogenetic response at 6 months. Older age group and female patients shows poor responses in comparison to younger age group and male patients of CML. Further study on large samples of CML patients is advised to search out the possible...
Read More
