Posted by admin on Jun 30, 2017 in |
Vascular malformations are one of the most common lesions of the oral cavity. The lesion may be a congenital malformation observed in neonates or arteriovenous malformation observed in adults. The treatment of these lesions includes surgical excision, cryotherapy, selective embolization and treatment with intralesional sclerosing agents. We present two cases of benign oral vascular lesions treated with intralesional injection of 30mg/ml sodium tetradecyl sulfate. One lesion virtually disappeared after one session of sclerotherapy, leaving a fibrotic lesion. No side effects were observed. The other lesion resulted in a severe inflammatory response including pain, swelling and surface ulceration up to more than 2 weeks. Sclerotherapy with sodium tetradecyl sulfate is effective in treating smaller benign oral vascular lesions, and the use of the sodium tetradecyl sulfate provides alternative or support for surgical methods. Larger lesions in critical anatomical areas may not be the best choice for treatment with Sclerosing agents. This paper presents the success and failure of vascular lesions treated with sclerosing...
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Posted by admin on Jun 30, 2017 in |
Ziprasidone HCl is a newly introduced atypical antipsychotic drug. It has its own unique multi receptor binding affinity. This makes it a unique special choice of antipsychotic agent. It mainly acts as antagonist of D2 dopamine receptors as and 5HT2A (serotonin, 5HT, 5-hydroxytryptamine) receptors. It is pinkish brown colored powder having very low solubility in water (21.12 mg/L). The main purpose of this study is to enhance the solubility of Ziprasidone HCl using lyophilisation technique. The β-Cyclodextrine and Hydroxy Propyl- β-Cyclodextrine were used as the water soluble carriers for increasing the solubility of Ziprasidone. All the inclusion complexes prepared by lyophilisation technique showed remarkable increase in the solubility compared to the pure Ziprasidone HCl. The saturation solubility analysis demonstrated highest increase in the solubility of drug after complexation with HP-β-CD by lyophilisation technique. The inclusion complexes were characterized using DSC and XRD technique. During in vitro study result obtained that the lyophilized complexes with HPβ-CD showed 100% drug release within 10 min were as the lyophilized complexes with β–...
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Posted by admin on Jun 30, 2017 in |
Curcumin has been shown to inhibit the activation of nuclear factor-κB (NF-κB), which is closely linked to chemo-resistance, in multiple myeloma cells. Malignant cells of this kind typically develop progressive multidrug resistance. Our aim was to investigate new possibilities for overcoming this resistance by suppressing cell signaling pathways. MTT-dye reduction assay was used to evaluate the cytotoxic activity of degrasyn, curcumin and Arsenic (ATO) on U-266, RPMI-8226 cell lines. Carfilzomib served as reference drug. Western blot analysis was performed. In RPMI-8226 cells evident activation of caspase 3 by ATO was seen. PARP cleavage was detected after degrasyn treatment. Curcumin led to PARP degradation as well. Caspase 9 was found to be activated by ATO, degrasyn and Carfilzomib. LC3b (autophagy hallmark) level was increased after exposure to ATO, curcumin and degrasyn. In U-266 cells significant LC3b increase was recorded after carfilzomib treatment. Procaspase 9 was cleaved after curcumin usage. Degrasyn activated procaspase 3. Elisa test was performed. All substances showed inhibition of NF-κB p65 fraction in both U-266 and RPMI-8226...
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Posted by admin on Jun 30, 2017 in |
The present study was conducted to evaluate the antioxidant, antibacterial and nutraceutical properties of three coloured scented rice varieties grown in North Eastern region. The study for the analysis of Nutraceutical content involved more than five contents to find a significant correlation of the all the rice varieties. Antioxidant activity was measured using hydrogen peroxide and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays. The antioxidant activities of the studied samples were expressed as percentage (%) of DPPH and H2O2 radicals inhibition and IC50 value. Among different extracts of crude rice, methanolic extract of the black rice showed highest antioxidant activity compared to the aqueous extract of the other two varieties each for DPPH (89.29±0.139) as well H2O2 (80.97±0.091) with an IC50 value of 40 µg/ml and 42.6µg/ml respectively. Also the result of MIC against the tested staphylococcus strain was notably found to be effective with a significant value of 119 µg/ml for black rice taken DMSO as the positive...
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Posted by admin on Jun 30, 2017 in |
The main objective of the present study includes the assessment of nutritional constituents and anti-oxidant activity of methanolic stem extract of Caralluma attenuata by in-vitro methods. In the present investigation the author has identified the phytochemical constituents which have nutritional importance by specific chemical tests, thin layer chromatography, atomic absorption spectroscopy for Calcium, Zinc and Magnesium. In vitro antioxidant property was also performed by Free Radical Scavenging Assay, Reductive Ability and Nitric Oxide Method. Carbohydrates, proteins and amino acids, flavonoids and inorganic essential trace elements were identified and the results were tabulated. On the basis of the results observed the methanolic stem extract of Caralluma attenuata found to possess considerable amounts of nutritional constituents and anti-oxidant...
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