Posted by admin on Dec 31, 2023 in |
Fast-dissolving tablets are a novel drug delivery system that provides the fastest onset of action and rapid pharmacological effects after administration. It can be administered simply by putting the tablets on the tongue, without the need for water. Mostly, this drug delivery system is efficient in emergency situations where an immediate drug response is needed. For the formulation of this kind of dosage form, natural and synthetic superdisintegrants, along with other excipients are required. In the pharmaceutical market, various kinds of synthetic and natural superdisintegrants are available. To find out which superdisintegrants give faster drug release, they are compared in the present research work. The aim of the present study was to formulate and characterise a fast-dissolving tablet using synthetic and natural superdisintegrants. The direct compression technique was used for the formulation of the fast-dissolving tablet. The formulated tablets are evaluated for precompression and postcompression parameters. From the results, it was concluded that among all the formulation batches, F3, F6, F9 and F12 were optimised, and on comparing their...
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Posted by admin on Dec 31, 2023 in |
This study was conducted to explore the anti-spermatogenic efficacy of hydro-methanol (2:3) extract of Thevetia peruviana leaves (TPHmLE) on rat. Rats of treatment group were orally treated with TPHmLE at the dose of 40 mg/0.25 ml DW/100 g of body weight over a period of 28 days and control group received only vehicle. The anti-fertility activity of TPHmLE was observed by significant reduction (P<0.05) of the organo-somatic indices, epididymal sperm count, motility, viability and hypo-osmotic swelling (HOS) test. The gonadotropins (LH, FSH), testosterone, interstitial Leydig’s cell count as well as 17β, hydroxyl steroid-dehydrogenase (17β-HSD) and Δ5, 3β – hydroxysteroid dehydrogenase (Δ5, 3β-HSD) activities in testis were decreased significantly in respect to control after the treatment of TPHmLE. Testicular superoxide dismutase (SOD) and peroxidase (POD) activities were significantly decreased in treated group but the lipid peroxidation status was significantly elevated indicated by high thiobarbituric acid reactive substance (TBARS), conjugated diene (CD) levels. From histological point of view, significant damage in germ cells of seminiferous tubule was observed by Feulgen, PAS,...
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Posted by admin on Dec 31, 2023 in |
The flavonoid compound quercetin is widely acknowledged for its diverse biological properties including anti-inflammatory, antioxidant, anti-bacterial, anti-ageing, anticancer however the constraints like poor solubility, low bioavailability, lack of stability and decreased permeability limits its pharmacological applications. Hydrogel assisted delivery systems especially for transdermal delivery of phytochemicals like quercetin is being suggested but least explored for its efficacy as an anti-inflammatory system. A PVA – alginate system was synthesized with quercetin and was explored for its effect as a potent anti-inflammatory system. The synthesized hydrogel was found to exhibit 56% loading efficiency and shown a sustained release over time as determined using HPLC analysis. The hydrogel system exhibited appreciable inhibition of total COX, 5 LOX, iNOS activity, Nitrate levels and MPO activity in RAW macrophage cells when compared with LPS alone treated groups affirming anti-inflammatory potential which can find applications in development of therapeutic regimens which will emphasize an economical, highly effective and risk-free plant drug with minimum side...
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Posted by admin on Dec 31, 2023 in |
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, including Phenolics, Terpenoids and Miscellaneous constituents. The findings of this study suggest that Ficus benghalensis bark extract may be a potential natural Anthelmintic agent. This activity was concentration dependent. As the concentration increases the extract produce maximal effect. Higher concentrations of ethanolic bark extract of Ficus benghalensis produce a paralytic effect much earlier and time taken for death was shorter. It shows maximum efficacy at 75 mg/ml concentration than the standard drug. Further studies are recommended to isolate and identify the active principles responsible for its activity. This could lead to the development of new drugs for the treatment of worm infections. The study provides valuable information on the medicinal properties of Ficus benghalensis...
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Posted by admin on Dec 31, 2023 in |
Introduction: Urolithiasis is one of the most common urologic diseases worldwide, with an estimated prevalence ranging from 1% to 13% across the globe. It’s increasing prevalence can be attributed to the westernization of lifestyle habits. The homoeopathic system of medicine offers a positive scope in the management of urolithiasis with hyperuricemia, prevent to undergo in surgical interventions and also prevents recurrence. Case Summary: The presented case involved a patient experiencing continuous severe pain in the right renal region for the past ten days, along with elevated uric acid levels. Bryophyllum pinnatum mother tincture was prescribed based on the acute presentation, followed by Lycopodium clavatum considering the chronic totality. This treatment approach resulted in a significant improvement in the patient’s presenting complaints. Objectively, the treatment led to a gradual decrease in serum uric acid levels, elimination the kidney calculus as observed in ultrasonography and reduced propensity for recurrent renal calculus formation. Additionally, the liver’s echo texture remained normal throughout the treatment. The modified Naranjo Criteria score (MONARCH) post treatment was...
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