Posted by admin on Mar 31, 2017 in |
To develop pulsatile microspheres of amlodipine and nifedipine drug release, a blend of polymer and solvent were used with pulsatile principles of drug delivery system to modified drug release pattern on and to release the drug at a particular time on the basis of lag time. In this study, we assessed the in vitro drug release pattern of the formulation prepared from different polymers ratio with the drugs of calcium channel blockers i.e. Amlodipine and Nifedipine. Different formulations of Amlodipine and Nifedipine were prepared using polymers Eudragit RS100, Eudragit S100, Carbopol 971P and polyvinyl alcohol. Optimum formulations were selected from both the drugs of pulsatile microsphere formulation such as formulation N12 from Nifedipine drug and A5 from amlodipine drug by conducting evaluation parameters for microsphere. In vitro studies were carried out for both the formulation and compared to each others. Kinetics drug released kinetics model fitted for both the drugs of optimum formulation for N12 and A5. Formulation N12 showed first order kinetics model and formulation A5 showed zero...
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Posted by admin on Mar 31, 2017 in |
Background: Woman’s risk for developing heart disease rises after menopause may possibly correlated with the striking increase in cholesterol levels. Objective: A randomized controlled cluster group single blind study was conducted by treating with dried curry leaf powder and cucumber slices in hyperlipidemic post menopausal women in rural area. Methods: Menopausal healthy women of rural communities (n =40; 45–65 years of age) with hyperlipidemia who were on with or without hypolipidemic drug were treated with dried curry leaf powder (5 g) adding in main side dish during lunch. Similarly another forty who were on with or without hypolipidemic drug were given100-125g cucumber slices before lunch for 45 consecutive days. A group of forty women with or without hypolipidemic drug was kept as the control. The demographic variables were collected using questionnaire. Fasting blood samples were collected before and after the intervention and lipid profile. Results: Among the total 120 subjects recruited, most of them (46.66%) had total cholesterol (TC) 200-239 mg/dl and 26.66% had high cholesterol. The low density...
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Posted by admin on Mar 31, 2017 in |
Objective: To rationalize the macroscopial, anatomical and physico-chemical studies on leaves of plant Dalbergia sissoo Linn. (Fabaceae). Methods: The crude ethanolic extract of leaves of Dalbergia sissoo Linn. (Fabaceae) was using physico-chemical parameters, fluorescence analysis, and preliminary phytochemical investigation (TLC, HPTLC, column chromatography). Results: An attempt has been made to highlight this folk herbal medicine through present study which will assist in the identification of fresh as well as dried crude samples of leaves anatomically and physiochemically. TLC fingerprint profiling and fluorescence analysis of powdered leaves were also carried out and the salient qualitative and quantitative parameters are reported. Conclusions: The present study will provide referential information for correct identification and help in checking adulteration in market samples used in the preparation of various herbal medicines. The present observation will also be helpful in macroscopical, microscopical and physiochemical studies on leaves of Dalbergia sissoo...
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Posted by admin on Mar 31, 2017 in |
Suddhi is a unique process of detoxification which is employed topotentiate as well as enhance therapeutic properties the effect of raw drugs. Nabhi (Aconitum ferox), a herbal poisonous rhizome commonly known as aconitum is used extensively in various Siddha formulations, with great therapeutic significance. Siddha system recommends the administration of Nabhi only after suddhi (purification) in different medias. Hence in this pretext one of the purification process of Nabhi mentioned in Theraiyar Yemaga Venba book gets validated scientifically with alleged reasoning through estimation of aconitine by HPTLC method and along with physicochemical parameters.The amount of Aconitine present is found to be reduced from 0.2107 % to 0.00 % after purification. In this present scenario may be presumed that the toxic compound aconitine might have been underwent transformation into some nontoxic compounds like Benzyl aconine and...
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Posted by admin on Mar 31, 2017 in |
Diacerein is an Osteoarthritic drug that exhibited suboptimal oral bioavailability upon oral administration of conventional dosage form. Nanosuspension gaining more attention for improving oral bioavailability of such drugs. This study was aimed to enhance the solubility and dissolution of diacerein by preparing Nanosuspension. Diacerein Nanosuspension was prepared using combination of High Speed Homogenization (HSH) and Media Milling (MM), Poloxamer 407 (stabilizer) and ZrO2 beads (milling media). Various formulation and processing parameters were optimized in preliminary studies. Concentration of stabilizer and milling media were optimized for Cumulative percentage release (%CPR), saturation solubility (SS) and mean particle size (MPS) using 32full factorial design. Optimized batch was derived statistically using desirability function of Minitab17. Model was validated by formulating checkpoint batch. Accelerated stability study was carried out for optimized batch. Identification and compatibility study of drug and stabilizers were carried out using FTIR and DSC studies. Preliminary parameters were optimized by varying one parameter at a time, while keeping other constant by trial and error method. Optimized batch has 100%w/v milling media...
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