Posted by admin on Mar 31, 2017 in |
The confined reports on Rhododendron arboreum Sm spp. nilagiricum (Zenker) Tagg stimulated to examine the bioactive compounds and the antimicrobial activity of its flower and bark extracts against medically critical human pathogenic microbes, apart from the availability of several reports on its main species R. arboreum. The microbial strains used for the study were four bacterial (Streptococcus pyogene, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae) and two fungal (Candida albicans and Trichoderma viride) strains. Agar well diffusion method is applied to assess the antimicrobial activity of the aqueous and methanol extracts of the plant sample. Various fractions of aqueous, ethanol, methanol and chloroform extracts confirmed the presence of alkaloids, phenols, flavanoids, tannins, saponins, terpenoids, steroids, carbohydrates, glycosides, amino acids and proteins. The methanol extract of flower revealed a promising antibacterial and antifungal activity against S. aureus and K. pneumoniae respectively. This study shows a broad and great therapeutic potential of the plant extract. However further studies are necessary for this potent plant extracts to evaluate the other parameters of antimicrobial...
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Posted by admin on Mar 31, 2017 in |
Self-medication is the selection and use of medicines by individuals to treat self-recognized illnesses or symptoms. Studies performed on self-medication reveal that it is a fairly common practice, especially in economically deprived communities. This Descriptive cross sectional study assessed the self‑medication issue among medical students of Aleppo Government University (AGU) and Al-Andalus Private University (APU) using Pre-tested and validated questionnaires. Among 436 students participated from two universities, the prevalence of self-medication was (60.5%, 40.9%) respectively. The highly significant difference (p< 0.001) was observed between self-medication rates between two universities. Whereas, the medication pattern for self-medication was similar among self-medicated students at two universities. Analgesics followed by antipyretics were the most drugs used for self-medication. Headache followed by fever and flu were the most frequent symptoms. The two main reasons for self-medication were mildness of illness and time-saving. Selection of medicine for self-medication was depends mainly on the recommendations of community pharmacists and they were the main source for obtaining self-medication drugs. This study showed that a significant number of...
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Posted by admin on Mar 31, 2017 in |
Adverse drug reactions in the form of toxic epidermal necrolysis is a rare but potentially fatal disorder. The pathophysiology of such reactions are not properly understood. There are many drugs which are very often implicated for causing such severe reactions. Allopurinol is a common drug used in chronic gout but also notorious for causing Steven – Johnson syndrome and rarely toxic epidermal necrolysis. Very often such reactions may cause severe morbidity and even mortality. Here, we describe a case of fatal toxic epidermal necrolysis caused probably due to allopurinol use in a 62 year old male. The event required immeditae reporting as it lead to the death of the patient. Immediate treatment is essential for combating such reactions and caution should be practised while prescribing such drugs. Moreover intense reporting of such cases will help us in understanding the pattern of such reactions and take necessary and timely...
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Posted by admin on Mar 31, 2017 in |
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Fluorescence quenching ananlysis reveal that the fluorescence quenching of curcumin is due to the formation of ground state complex between curcumin and hyperbranched poly(amide-ester) and the binding constant was 3.98×105L·mol-1. The other analysis also can prove the formation of complex between curcumin and HBPAE. The solubility of curcumin in aqueous solution was greatly increased more than 1000-fold at the presence of hyperbranched...
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Posted by admin on Mar 1, 2017 in |
Mn(II) complexes with four semicarbazide and thiosemicarbazide based ligands such as 2-formyl pyridine semicarbazone (L1), 2-formyl pyridine thiosemicarbazone (L2), 5-methyl 2-formyl pyridine semicarbazone (L3) and 5-methyl 2-formyl pyridine thiosemicarbazone (L4) have been synthesized and characterized. All the ligands were characterized by elemental analyses, IR, 1HNMR and mass spectral studies. The complexes were characterized by using various physicochemical techniques such as elemental analysis, molar conductance, magnetic susceptibility measurements and spectral studies such as IR, UV-visible and EPR. The complexes were found to have general compositions Mn(L)2X2 [where L = L1, L2, L3 & L4, X = Cl–, NO3–]. The molar conductance data of chloro and nitrato complexes of L1, L2, L3 and L4 suggest nonelectrolytic nature of the complexes. Therefore they may be formulated as [Mn(L)2X2].Complexes show magnetic moment corresponding to five unpaired electrons. On the basis of IR electronic and EPR spectral data distorted octahedral geometry of complexes has been...
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