Posted by admin on Feb 28, 2017 in |
Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark was extracted with aqueous ethanol (70%) and quantitative analysis for total phenolic content, total alkaloids and flavonoids was carried out on the dried extract. The hypoglycaemic effects of aqueous A. stenophylla root bark extract, powdered Zingiber officinale and powdered Citrus Limon peels was determined on alloxan-induced diabetic rats singly and in combinations over 14 days. Glibenclamide administered at 0.2 mg/kg b. wt was used as the positive control. Results: All the plants decreased plasma glucose levels in a dose-dependent manner. The glucose levels of diabetic rats treated with all the plants combined showed the greatest reduction (59.2%). A. stenophylla and Z. officinale showed a glucose level reduction of 47.7%, A. stenophylla and C....
Read More
Posted by admin on Feb 28, 2017 in |
Structural and thermal properties of silver/poly(vinyl alcohol) (Ag/PVA) nanocomposites has been investigated as a function of Argon ion beam fluence. The XRD patterns (X-ray diffraction) showed the formation of the Ag/PVA in polymer structure and phase analysis with different sizes as a function of either ion beam fluence or Ag+ ion molar concentrations. The kinetic parameters for the thermal stability of Ag/PVA were evaluated applying Thermal Gravimetric Analysis (TGA), the decomposition temperature increase from 302 0C for pure PVA to 345 0C for irradiated Ag nanofillers /PVA with ion beam fluence 3.0 x 1018 ions.cm-2 at 0.8 % AgNO3 concentration . Fourier transform infrared spectroscopy (FT-IR) exhibits the creation of polar groups on the surface which are responsible for surface wettability improvement. From the above, this procedure is simple and useful for large scale synthesis and which make this material as a candidate medical devices and for drug delivery...
Read More
Posted by admin on Feb 28, 2017 in |
Objectives of study: To develop and validate new, rapid, selective, precise, accurate and economical, isocratic RP-HPLC and UV spectrophotometric method for simultaneous estimation of Dextromethorphan and Quinidine in bulk and in tablet formulations. Methods: A RP-HPLC was developed for the simultaneous estimation of Dextromethorphan and Quinidine on Phenomenex C-8 column with the mobile phase of methanol and phosphate buffer (pH 2.5) in the ratio 60:40 v/v at flow rate of 1ml/min and detection at 230nm was used for the study. In UV spectrometry, simultaneous equation method was based on measurement of absorbances at two selected wavelengths 278nm and 331nm for Dextromethorphan hydrobromide and Quinidine Sulfate respectively. Absorbance ratio method based on the measurement of absorbances at isobestic point and wavelength maxima of one drug, selected wavelengths were 278nm (λmax of DMH) and 289nm (isobestic point). The developed methods were validated and recovery studies were carried according to ICH guidelines. Results: The peaks of Dextromethorphan and Quinidine were found to be well resolved with retention time of 4.3min and 2.8min...
Read More
Posted by admin on Feb 28, 2017 in |
Hepatoprotective activity of Polyherbal preparation against CCl4 ‑induced hepatic damage in rats was observed. The healthy control (normal), control, and standard drug Silymarin treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALP and total Bilirubin were assessed in all the experimental groups. The changes in liver function parameters were significant in comparison to control group and the observed efficacy was comparable to standard drug. The efficacy of the polyherbal preparation was found to be dose dependent. From the present study it is evident that the Polyherbal preparation has no mortality in selected doses. Liver antioxidant markers were elevated significantly, while the serum and lipid parameters were maintained at normal levels compared to control groups. Histopathological examinations of the liver showed that extract and Silymarin have a protective role over the toxicity of paracetamol and carbon tetrachloride induced hepatotoxicity in rats. Hence Polyherbal preparation could be one of the best sources of natural hepatoprotective...
Read More
Posted by admin on Feb 28, 2017 in |
An ethnobotanical study of medicinal plants was carried out in the region of Oued Tlelat. It was made in order to establish the catalog of medicinal plants and gather all information on the therapeutic uses practiced by the local population in the study area. The results have identified 59 species that are divided into 29 families of which three are the most dominant, especially Lamiaceae, Apiaceae, and Fabaceae. The most cited plants Thymus vulgaris, Menthaspicata and Verbena officinalis. The foliage is the most used part and most of the remedies are prepared as an infusion. In terms of treated diseases, respiratory diseases occupy first place with a rate of 31.74%. This study highlights the medicinal plants used in the treatment of different type’s diseases (Respiratory, metabolic disorders, neurological disorders, dermatological infections, genitourinary infections) by the population of the study area. The results are a valuable source of information and a database for research in the field of...
Read More
