Posted by admin on Feb 28, 2017 in |
The aim of the study was to evaluate the central and peripheral analgesic activities of Solanum melongena ethanolic leaf extract in experimental animals. The Solanum melongena leaves were air dried at room temperature and were ground to a fine powder. Ethanolic extract was obtained by percolating the dried powder with 95% ethanol. Oral toxicity test was done according to OECD guidelines. For evaluation of central analgesic activity hot plate and tail flick methods were performed. These methods were carried out in healthy albino rats (Rattus norvegicus) of either sex weighing 100-200 gm. Thirty animals were used in each method. They were divided into five groups with six animals in each group for both methods. Solanum melongena ethanolic leaf extracts (500mg/kg) was used as test drug and Pethidine (5mg/kg) was used as the standard drug in these methods. For evaluation of peripheral analgesic activity, acetic acid induced writhing test was performed in albino mice. Total 18 healthy albino mice of either sex weighing 20–30 gm were used. They were divided...
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Posted by admin on Feb 28, 2017 in |
Pharmacy profession has responsibility for ensuring the safe, effective and rational use of medicines. Effective pharmacy practice requires an understanding of the social context which is practiced, innovative and informative. The aim of the study was to find out the Knowledge towards digital library and innovation in pharmacy practice by Questionnaire based Prospective study on pharmacy-medical professionals. The participant subjects to enrolled in study and asks self prepared 30 questions. The information’s were obtained on special form and data was analyzed by SPSS software. The result were found that 66.6% of participants were agrees that digital library makes treatment better where as 33.34% were not able to say about digital library role in better treatment outcomes. 53.33% thought that through 40 % slightly agreed. 56.66% study population positive to say the importance of electronic application of digital library minimize adverse drug reaction, 6.66% were not thought so and contents is increasing day by day in health care profession, 43.33% had negative thinking on the same. 73.33% said and agree...
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Posted by admin on Feb 28, 2017 in |
Lithiasis is the process of stone formation in the kidney, bladder, and/or urethra. Herbal drugs are reported to be effective in the treatment of urolithiasis with no side effects. Grewia asiatica is a plant commonly used as a traditional herbal medicine and possesses the wide range of pharmacological applications. The present study investigated the antilithiatic activity of an ethanolic leaf extract of Grewia asiatica Linn (EEGA). Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased urinary volume and its pH. EEGA (200 & 400 mg/kg) was given orally in curative and preventive regimens over a period of 28 days. Supplementation with EEGA significantly (p<0.05) restored urea, uric acid, creatinine, volume of urine and pH levels. The preventive regimen was found to be better than the curative regimen. The results were comparable with the standard drug, Cystone (750 mg/kg). Histopathological examination further corroborated the antilithiatic or nephoprotective activity of the extract. The presence of triterpenoids, flavonoids and saponins in extract might be responsible for significant antilithiatic...
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Posted by admin on Feb 28, 2017 in |
Flavonoids are natural products widely distributed in plant kingdom that gained lot of importance due to variety of biological effects relevance to numerous healthcare. It has been chosen as a drug molecule and gained attention in the area of novel drug delivery system because of their disease preventing property and therapeutic expediency in multiple biological effects. Chrysin (C) is one of the most utilized flavonoid having pharmacological effects such as anti-oxidant, anti-inflammatory, anti-cancer, antidiabetic and anti hypertensive actions. Even though it has potential therapeutic value and beneficial effects on human health, it possesses some disadvantages like poor solubility and low bio-availability, this limits its therapeutic usage of Chrysin. The present work designed to improve the solubility and the bioavailability of chrysin by the developing a chrysin loaded chitosan nanoparticles (NC). It was prepared by ionic gelation of chitosan and tripolyphosphate. The chrysin loaded chitosan nanoparticles were prepared in 5 batches and named as NC1, NC2, NC3, NC4 and NC5. The formulated nanoparticles were characterized by particle size analyzer, Zeta...
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Posted by admin on Feb 28, 2017 in |
Adiponectin has been schown to protect from insulin resistance, demonstrate anti-inflammatory and anti-atherosclerotic effects and be involved in the pathogenesis of metabolic syndrome (MS). We aimed to assess the association between serum adiponectin concentration, insulin resistance and various risk factors of MS and to investigate the relationship between the single nucleotide polymorphism (SNP) +45 T>G ( rs 2241766) in the adiponectin (ADIPOQ) gene and the risk of MS. 200 patients with MS and 250 healthy controls were enrolled in this study. The level of fasting serum insulin, glucose, and lipid levels were measured. Insulin resistance was estimated using homeostasis model of assessment for insulin resistance (HOMA-IR). Serum adiponectin levels were measured by enzyme-linked immunosorbent assay and the SNP +45 T>G in the ADIPOQ gene was performed by the polymerase chain reaction-restriction fragment length polymorphism method. MS patients had a significantly higher levels of HOMA-IR (p<0.001) and lower serum adiponectin concentrations (p<0.001) compared to controls. Multiple regression analysis showed that serum adiponectin levels was associated negatively with HOMA-IR (r=-0.307; p=0.001)...
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