Posted by admin on Apr 30, 2017 in |
Purpose: To prepare and evaluate floating tablet of curcumin for prolonged gastric residence time and increased drug bioavailability for the treatment of gastric problem. Methods: Floating tablet were prepared by wet granulation method using different ratios of Curcumin, Psyllium husk, HPMC K 15 M, HPMC K 100 M and Mangifera indica gum. The respective powders were blended thoroughly and a dump mass was prepared by adding the granulating agent. Dump mass was passed through sieve number 10 and dried in hot air oven at 50 0C for 30 mins. After drying, granules were further passed through sieve number 22 to attain the uniformity in granules. Finally, optional additives like magnesium stearate and talc were added and finely blended for preparation of floating tablet. Result: Floating drug delivery tablets were being formulated and the present study focused on the formulation of FDDS by using different polymes like phyllium husk, HPMC K 100 and HPMC K15 and to evaluate its efficacy in reducing ulcers caused by H.pylori. The Floating drug delivery...
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Posted by admin on Apr 30, 2017 in |
Mucoadhesive buccal patches provide a wide variant of therapeutic effect via mucosa and buccal region of the mouth. They provide zero first pass metabolism and high bioavailability providing patient compliance. In the present study, buccal patches of paracetamol were developed to improve the bioavailability and half life of the drug. In the process of its preparation binder plays a greater role in holding the drug. One of such is Tamarind seed polysaccharide (TSP) isolated from the kernels of Tamarindus indica seeds was used as a binder in the preparation of paracetamol mucoadhesive buccal patches. Here, solvent casting method was employed and performed various evaluation parameters. Mucilage extracts at 0.5,1, 1.5, 2, 2.5% concentrations were used. All the patches were shown smooth surface and elegant texture. The weights of (10 mm) patches were in the range of 21.6 to 26.8 mg. The results indicate that the formulation with 2% mucilage extract shows maximum drug release. Among the five formulations (F1 to F5), F4 formulation showed maximum percentage of drug...
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Posted by admin on Apr 30, 2017 in |
The extraction of stem bark of Terminalia arjuna using different extraction methods viz. room temperature extraction (RTE), soxhlet extraction (SE), Ultrasound assisted extraction (USAE) and microwave assisted extraction (MAE), estimation of the percentage yield of marker compounds arjunic acid and arjunolic acid present and in vitro evaluation of urease inhibitory activity of the extracts has been investigated. The quantitative estimation of the yield of marker compounds was done using HPTLC using standard plot technique. The molecular docking of the marker compounds was performed on urease 3LA4 enzyme protein. The in vitro urease inhibitory activity of the extracts was performed spectro photometrically taking thiourea as standard. The percentage yield of the marker compounds was in order MAE>USAE>SE>RTE. The molecular docking study suggested that the arjunic acid (-55.511 Kcal/mol) exhibited better results of inhibition compared with the free energy values of arjunolic acid (-40.765 Kcal/mol) and standard thiourea (-25.846 Kcal/mol). The in vitro urease inhibitory activity of the extracts also followed same pattern as for the percentage yield of the marker...
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Posted by admin on Apr 30, 2017 in |
A new, simple, sensitive, precise, accurate and stability indicating RP-HPLC method has been developed for the simultaneous determination of N-Acetyl-L-cysteine and Ambroxol Hydrochloride in combined tablet formulation. The combination is mainly used as mucolytic. The study aimed at developing and validating a method which can be used easily and effectively for determination of given drugs in various formulations. The analysis was carried out at 220 nm and the range was obtained as 3-18 µg/ml for AMB and 20-120 µg/ml for NAC. Recovery studies indicated that the drug recovery from the formulation was within acceptable limits. The developed method was statistically evaluated. The %RSD values reported were less than 2 all through the validation which indicates variations in the results are minimal. Thus the proposed method of analysis was found to be simple, sensitive, accurate, precise, rapid and also economical and can be applied successfully for simultaneous estimation of both N-Acetyl-L-cysteine and Ambroxol Hydrochloride in bulk and combined tablet...
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Posted by admin on Apr 30, 2017 in |
Background: The relation between Chronic Kidney Disease (CKD) and cognitive impairment is an important public health issue because the prevalence of CKD is increased worldwide. In recent years, chronic kidney disease has been proposed as an independent risk factor for cognitive decline but the available data are conflicting. In the present study, we examined the relations of CKD and lower renal filtration function with a broad range of cognitive functions in a dementia-free community-based population. Methods: A cross-sectional, observational, questionnaire based study was conducted at Nephrology department of Govt. Medical College, Calicut. Montreal Cognitive Assessment Questionnaire was used to assess cognitive status. Patient’s divided into 5 groups depending on stage of chronic kidney disease. Estimated glomerular filtration rate was calculated using modification of diet in renal disease equation. Results: 210 patients were enrolled in the study. 53.8% have mild cognitive impairment and 46.2% have normal cognitive status. Education with cognitive status was found to be statistically significant (P=0.000). Conclusion: Decreased kidney function associated with greater cognitive decline, even in...
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