Posted by admin on Feb 29, 2024 in |
Introduction: Topical corticosteroids are mainstay of treatment for many skin conditions but extensive prescription of them may lead to increase in adverse reactions. So, periodic audit of prescriptions will help in enhancing the therapeutic effectiveness and reduce the adverse effects. Objective: To study sociodemographic data and drug prescription pattern in patients with skin diseases. Methodology: Prospective observational drug evaluation type of study conducted at tertiary care teaching hospital during January to December 2018. Secondary data analysis was conducted of 500 prescriptions of dermatologists which were selected randomly in semi structured proforma. Data was analysed as counts and percentage. Results: Total 1551 drugs were prescribed to 500 patients visiting dermatology Outpatient department. Most frequently in 180 prescriptions, 3 drugs were prescribed. Antiallergic are most frequently prescribed drugs (24.3%) followed by Steroids (15.7%). In almost all prescriptions Generic name of drugs, Strength and Duration of treatment were mentioned. Among prescribed steroids topical corticosteroids were prescribed in 69.1% of prescriptions and in topical corticosteroids Clobetasol propionate forms more than half part (53.3%)...
Read More
Posted by admin on Feb 29, 2024 in |
Normally and often skin infections present therapeutic challenges to practitioners and researchers due to the growing concern regarding multi-drug resistant bacterial, Viral, and Fungi Strains. The Antibacterial properties of zinc sulphate and copper sulfate are well known and have been investigated for many previous years. However, the synergistic effect between both metal ions as antibacterial ingredients has not been evaluated in topical formulations like gels and creams. The aim of the present study to formulate cream and gels containing zinc and copper individually or in combination and evaluate the in-vitro antibacterial activity of these metal ion in the formulation. Zinc sulfate and copper sulfate had a strong synergistic antibacterial activity in cream and gels. By evaluating the various parameters such as pH, Spreadability, viscosity, and antibacterial properties it is confirm that the metal gel and cream enhance the antibacterial activity. This study evaluated and confirmed the synergistic in-vitro antibacterial effect of copper sulfate and zinc sulfate in cream and...
Read More
Posted by admin on Feb 29, 2024 in |
Nowadays, many clinical studies have provided reliable results on the effects of several herbal medicines on many diseases such as kidney problems. The objective of this study is to evaluate in-vitro the antiurolithiatic activity of polyphenols, flavonoids, and alkaloids fractions of the leaves of the species Ziziphus lotus. The quantification of the polyphenol and flavonoid fractions was carried out by spectrophotometric methods; on the other hand, the alkaloid fraction is quantified gravimetrically. The antiurolithiatic activity of the fractions is studied by the use of the turbidimetric and gravimetric techniques. The polyphenol content varies between 1198,696 ± 99,848 and 15270,751 ± 290,419 (μg GAE)/g). While flavonoids range from 97,340 ± 8,437 to 1745,864 ± 8,690 (μgQE/g). On the other hand, the alkaloid fraction represents 1. 26%. The polyphenols fraction showed a higher inhibition 89.80 ± 0.69 than the two other fractions which represent the values 84.17 ± 1.11 and 78.90 ± 1.40, respectively. The polyphenols fraction (AF: 86.66 ± 1.43) and flavonoids (DMF: 80.85 ± 2.03) show an increasing evolution...
Read More
Posted by admin on Feb 29, 2024 in |
Production of nanoparticles using plants is a new area of interest. Plum fruit extract was used for the biosynthesis of zinc oxide nanoparticles. Green synthesis of zinc oxide nanoparticles are considered as a eco-friendly methodusing materials from plants and other natural sources without using anyharmful chemicals. Plum fruit has many medicinal values such as antioxidant activity, cardiovascular activity, anti-inflammatory and antimicrobial effect. Present paper discuss about the green synthesis of zinc oxide nanoparticles using Prunus domestica (plum) fruit extract, Its characterization by analytical studies, antimicrobial and antioxidant studies. Plum fruit extract also subjected to phytochemical screening. The active constituents present in Plum were identified as alkaloids, glycosides, phenolics, flavonoids, proteins and carbohydrates. Nano particles were characterized by UV-Visible Spectroscopy, FT-IR and SEM studies. In the UV visible spectrometer absorption peak was observed at 362 nm, which is specific for zinc oxide nanoparticles. Synthesized zinc oxide nanoparticles were subjected to FT-IR analysis to detect the various characteristic functional group associated with the synthesized nanoparticles. The peaks indicate the characteristics functional group...
Read More
Posted by admin on Feb 29, 2024 in |
Introduction: Carcinoma cervix is the major health problem with increased morbidity and mortality. Around 60% of cases are diagnosed at an advanced stage, making the treatment more complex. Pap smear can able to detect precancerous and cancer of cervix along with infection and inflammatory pathologies making the clinician in timely and appropriate management. Objective: This study aims at detecting the prevalence of current trends of nonneoplastic and neoplastic lesions of cervix in patients who attending our tertiary care centre. Materials and Methods: This is a prospective study done in Srinivasan medical college and Hospital for a period of 6 months in patients who attended gynaecology department. Smears were made and stained with Pap stain after fixation in ethyl alcohol. Reporting was done based on the Bethesda system 2014. Results: Out of 500 cases, 495 cases (99%) were satisfactory for evaluation. Of these, 470 (94%) cases were negative for intraepithelial lesion/malignancy and 24 cases (4.8%) shown epithelial cell abnormalities. Nonspecific inflammation contributed 30.6% cases, infections like Bacterial vaginosis were seen...
Read More
