Posted by admin on Jan 31, 2017 in |
N-heterocyclic compounds have extensive biological and pharmaceutical applications. 8-Hydroxyquinoline (8-HQ) also plays a significant role in many fields of life. The excellent biological significance of the 8-HQ prompted us to extend the DFT based studies. The frontier molecular orbitals (FMOs), UV-VIS and solvation model based studies remained unknown. Therefore, we intended to study the natural bond orbital, FMOs, UV-VIS, thermodynamic properties and medium influence on solvation energies, dipole moment, FT-IR and FT-Raman using polarizable continuum model (PCM) and density-based solvation model (SMD). The electronic properties of molecule were calculated by M06-2X/6-31G (d,P) and B3LYP/6-31G (d,p) level of theories. The solvent influence on the geometric parameters, FT-IR and FT-Raman were studied by B3LYP /6-31G(d) method. A good correspondence is found between the optimized parameters and the reported X-ray data. Natural bond orbital reveals that the maximum stabilization energy reached up to 39.64kJ/mol which is responsible for extra stability of the molecule. In solvated 8-HQ, a significant medium effects on FT-IR and FT-Raman intensities is observed. The intensities enhanced from gas...
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Posted by admin on Jan 31, 2017 in |
Postpartum period is an important step because the mother’s body needs to heal and recover, after pregnancy period and childbirth. So taking good care and a balanced diet in the postpartum period, plays an important role in the women’s health. Thus, training of nutrition is so necessary at this period. The aim of this study was an evaluation the effect of the pregnancy period preparation classes on the nutritional behavior of the postpartum period. This research is a semi-experimental study. 230 number of the nulliparas admitted to the health centers selected by stratified-cluster sampling method and were placed in the intervention and control groups. Classes for the intervention group were held once every one week in the eight sessions and the duration of each session, was one hour. Collection of data was conducted through questionnaires and in order to its analysis, SPSS software was used. The results for this experiment showed that the groups of intervention and control, were similar in terms of the demographic characteristics but there was...
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Posted by admin on Jan 31, 2017 in |
Uric acid is the end-product of purine metabolism and a major antioxidant in humans. Most of the uric acid produced from the catabolism is readsorbed into the blood circulation system after primary filtration and partial secretion by the kidney. Uric acid levels in physiological fluids such as plasma and urine serve as valuable indicators for certain clinical conditions. An elevated uric acid in urine or serum can affect renal function and blood pressure, which is an indicator of gout, cardiovascular and renal diseases, hypertension, etc. Low uric acid levels may be associated with molybdenum deficiency, copper toxicity and worsening of multiple sclerosis. Therefore, detection of uric acid level dissolved in human physiological fluids is indispensable for diagnosis of patients suffering from these disorders associated with altered purine biosynthesis and catabolism. In this article the studies of detection methods for uric acid in biological samples in recent years are...
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Posted by admin on Jan 31, 2017 in |
Lansoprazole a proton pump inhibitor used in the short term treatment of gastric and duodenal ulcer, reflux esophagitis, structuring and erosive esophagitis. In the present investigation an attempt has been made to enhance the solubility and dissolution rate of lansprozole by formulating it as solid dispersions with KollidonVA64, Soluplus and poly ethylene glycol 6000 by solvent evaporation method. The solid dispersions were further compressed as tablets by using superdisintegrants such as croscarmellose sodium (CCS) & crospovidone (CP). Rapid release of lansoprazole from solid dispersions was observed which was influenced by the proportion of carrier concentration. Among the solid dispersions prepared the dispersion formulated using Soluplus showed rapid drug release than kollidon & PEG 6000 containing Solid dispersions and pure drug alone. The release was found to follow the first order kinetics. Solid dispersions prepared by the solvent evaporation method were further formulated into tablets with superdisintegrants such as croscarmellose sodium, crospovidone. The dissolution rate of such tablet formulations were found to release the drug at a faster rate than...
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Posted by admin on Jan 31, 2017 in |
Alcohol abuse is well known to impair reproductive performances due to impaired testosterone production and testicular atrophy. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of alcohol induced sterile male albino rats. A total of 30 healthy young male albino rats were selected. A total of 24 rats were subjected to 3gm of ethanol/kg body weight/day orally for 4 weeks for experimental rats. Cc and Is extract 200mg/kg body weight were administered orally to the experimental albino rats E-I (n=6) and E-II (n=6) respectively and compared to the positive control albino rats PC (n=6) which was administered testosterone 10µg/kg body weight subcutaneously, biweekly with that of the alcohol induced sterile control rats SC (n=6) using various parameters such as sexual behavior, weight of animals, dimension and weight of testes, hormone, semen, and histological analysis. Restitution of fertility was compared with the normal fertile controls rats...
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