Posted by admin on Feb 28, 2017 in |
The rationale of the present study was to formulate & optimize the floating Bupropion HCl microsponges by 23 factorial design. The concentration of ethyl cellulose (EC), polyvinyl alcohol (PVA) and Dichloromethane (DCM) were selected as independent variables. Floating lag time & % drug release were selected as independent variables. Factors, their levels (with values) were substituted in the design of experiment software (Sigma tech version 3.1). The effect of factors at different levels on response variable was predicted using poly nominal equations. FTIR studies revealed that no chemical interaction between drug & polymer used. DSC confirmed molecular dispersion of drug in the microsponges polymer matrix. Quasi emulsion solvent diffusion method was used to formulate microsponges. Bupropion HCl showed acceptable flow. The morphology of microsponges was studied using SEM and it was found that microsponges were spherical and porous. USP Type II dissolution apparatus with cellophane membrane was used to study in vitro drug release. Kinetic studies revealed that drug release from optimized formulation followed Higuchi’s model and diffusion is...
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Posted by admin on Feb 28, 2017 in |
In view of therapeutic values associated with Syzygium cumini and increasing consumer demand for functional foods, a non-conventional alcoholic beverage prepared from the stem of Syzygium cumini was evaluated for its efficacy against streptozotocin-induced diabetes mellitus in male wistar rats. The beverage was observed to be safe for consumption as it did not produce any anomalies in the biochemical markers of liver and kidney of normal rats, rather exerted protective effects on hepatic and renal functions by improving the levels of biochemical indicators. After an oral administration of a daily single of dose of 4ml/kg for a period of 30 days, stem beverage was able to rectify the abnormalities in blood glucose levels, lipid profile and atherogenic index of diabetic rats. The beverage also arrested the deviations in hepatic and renal functions of diabetic rats. Histological studies of pancreas also confirmed the anti-diabetic behaviour of stem beverage. The pharmacological properties of the beverage can be ascribed to the presence of various phenolics and tannins in it. The use of...
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Posted by admin on Feb 28, 2017 in |
A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program called VALSTAT. The best models were selected from the various statistically significant equations. The study revealed that descriptors molecular weight (MW) and Connolly solvent excluded volume (cn sev) reduces the activity, where as molar refractivity (MR) enhances the anticancer activity. The analysis resulted in QSAR equation, which suggests that, n=27, r = 0.9115, r2 = 0.8308, adjusted r2 = 0.8087, standard deviation (std) = 0.0915 and q2 = 0.7644. The results obtained from QSAR studies could be used in designing better anticancer agents among the congeners in...
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Posted by admin on Feb 28, 2017 in |
Some new hydrazino group substituted benzothiazole derivatives have been synthesized and their characterization was done by IR, NMR and MASS spectral data. The antimicrobial activities of these synthesized compounds was done by cup-plate diffusion method in DMSO against some Gram positive and Gram negative bacteria. Some of synthesized derivatives exhibited potent activity when compared with standard drug...
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Posted by admin on Feb 28, 2017 in |
Reverse Phase – High performance liquid chromatographic (RP – HPLC) method was described for determination of Ambroxol Hydrochloride (AMB) and Cefadroxil Monohydrate (CEFXL). The chromatographic separation was achieved using mobile phase mixture of Acetonitrile and 0.05 M Dihydrogen Phosphate Buffer (pH 3.0 adjusted with Ortho Phosphoric Acid Solution) in the ratio of 40:60 (%v/v) and Eclipse Plus C18, (150 x 4.6 mm i.d), Particle size 5 mm column at 1.0 ml/min flow rate. 20 µL of standard preparation containing 30 µg/ml AMB and 250 µg/ml CEFXL was injected into the column and the component was separated by carrying out elution for a run time of 15 minutes and detected at 230 nm wavelength. The described method shows excellent linearity over a range of 6 to 60 μg/ml and 50 to 500 μg/ml for AMB and CEFXL, respectively. AMB and CEFXL were subjected to stress degradation conditions of hydrolysis (acid and base), oxidation and thermal degradation. Stressed samples were analysed by the developed method. The proposed method was readily applied...
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