Posted by admin on Feb 28, 2017 in |
Background: Metabolic syndrome (MetS) is a defined cluster of cardiometabolic abnormalities that increases an individual’s risk of type2 diabetes (T2D) and cardiovascular disease (CVD). Heart fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, pulmonary embolism. The aim of this study was to investigate serum H-FABP value in the patients with MetS. Methods: We measured serum H-FABP levels in 209 adult Tunisian MetS patients (108 diabetic MetS and 101 non-diabetic MetS) matched by gender and ethnic origin and 193 control subjects, using immunoturbidimetric method. All subjects underwent anthropometric and biochemical examinations. Results: Serum H-FABP levels were significantly higher in patients with MetS than in control subjects 9.80±4.75 and 3.78±1.04 ng/ml, respectively, (P<0.001). Serum H-FABP levels were significantly higher in patients with diabetic MetS than in without diabetic MetS, 12.63±4.92 and 6.77±1.80 ng/ml,...
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Posted by admin on Feb 28, 2017 in |
This study was carried out with goal to predict the inhibition of Aurora Kinase B by a series of Oleocanthal by molecular modeling. During last year’s Kinases Aurora were emerged like one of the important targets of drug in several pharmaceutical companies and industries of research and it plays a main function in the regulation of the mitosis and the cytocinèse 1 and for this reason one inhibited these Kinases Aurora B with a series of oleocanthal derivatives as legand can simultaneously induce the autophagy and apoptose in the tumoral cells. To understand the complexation mechanisms in the biological system call was made at the molecular docking, we used MOE software. was optimized geometries of all ligands, in result, the calculation of the score of energy was made to form the complex and identify the interactions in the two media a solvated (water solution) and the other unsolvated in the end we find that the ligands L5 and L6 haves the lowest...
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Posted by admin on Feb 28, 2017 in |
Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents of the leaf extracts were determined. The antioxidant activity of the extracts were investigated using DPPH, ABTS, nitric oxide scavenging assays, phosphomolybdenum assay, reducing power and metal chelating assay. Antimicrobial activity was tested against MTCC strains and MDR clinical bacteria. The antiproliferative activity was determined using MTT assay against three cancer cell lines. Results: Extracts showed high total phenolic content ranging from 85.7± 1.15 to 40.3± 0.6 gallic acid equivalents and flavonoid content ranging from 750±5.5 to 140±3.6 quercetin equivalents per gram of dry extract. Ethyl acetate extract showed highest DPPH scavenging activity with an EC50 value of 330μg/ml. The antimicrobial effects of all the extracts were found to be genus specific – only against Klebsiella spp. The chloroform...
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Posted by admin on Feb 28, 2017 in |
Aim: The study was done to evaluate the antibacterial and antifungal activity of the leaves of Colocasia esculenta Linn. Materials and Methods: Fresh tender leaves of C.esculenta collected, air-dried at room temperature, grounded to a fine powder and extracted with ethanol. The antibacterial and antifungal activity of C.esculenta compared to standard antibiotics was assessed by disc diffusion method by measuring the zone of inhibition. The organisms used for the test were Staphylococcus aureus, Klebsiella, Escherichia coli and Pseudomonas aeruginosa and Candida albicans. The agar disc diffusion method described by Kirby-Bauer was used for testing the antibacterial and antifungal activity. Results: Zone of inhibitions produced by sensitive organisms were demarcated by a circular area of clearing around plant extract impregnated discs and measured in millimeter (mm). Mean ± SEM was calculated and the data was statistically analysed by one way ANOVA followed by Dunnets multiple comparison test. Conclusion: In our study, ethanolic extract of Colocasia esculenta showed antibacterial activity against S. aureus, P. aeruginosa, E.coli, Kleibsiella and antifungal activity against...
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Posted by admin on Feb 28, 2017 in |
The studies on tree biomass for assessing carbon density in tropical forest ecosystem of central India was undertaken during 2009-11 in forest area of eight districts [Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria] at 30 adopted representative sites at varying latitudes and longitudes. The annual rainfall of their study area was 1000-1600 mm. The soils of the study sites were alluvial, light to medium black as well as red and yellow with pH value ranging from 5.5 to 80. The study was confined in three vegetation type viz., teak mixed, salmixed and mixed forest. In the study new approach was adopted by using ground data as well remote sensing data to get an accurate estimate of vegetation carbon pool in the region. Among the 30 selected site ID, Tectona grandis was dominated at 10 side. The basal area and volume of tree species in forest study sites ranged between 0.8 to 169.68 m2/ha and 0.11 to 2, 31299.82 m3/ha. The maximum tree biomass/ha recorded for Shorea roubsta...
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