Posted by admin on May 31, 2017 in |
One of the factors responsible for malaria pathogenesis is the suppression of host immune responses. This suppression enhances parasitemia and diminishes the host immune response to malaria-expressed proteins and other pathogens. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the design of new therapeutic products against malaria. In the present research, some novel compounds are synthesized and targeted against hemozoin growth. The consideration of new chemotherapeutic targets in malaria research is most likely to identify new classes of drugs. The present work deals with the synthesis of a small library of 2-alkoxy/phenoxy-3-amino-3-arylpropan-1-ols by reductive ring opening of the corresponding azetidine-2-ones. After characterization of synthesized compounds, these were evaluated for hemozoin formation inhibition assay. The results showed that all compounds are inhibiting hemozoin formation comparable to Clotrimazole. This may be concluded that the synthesized compounds exhibit antimalarial activity via inhibition of hemozoin...
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Posted by admin on May 31, 2017 in |
Background: According to World Health Organization the global prevalence of musculoskeletal disorder ranges from 14% to as high as 42%.Teachers are generally prone to neck, shoulder and low back pain . The work tasks of school teachers often involve significant use of a head down posture, such as frequent reading and marking of assignments. According to World Health Organization working with a heavily bent, extended or twisted trunk can result in an overload of spinal structures and increased activity of the entire muscles. Objective: To find out the prevalence of musculoskeletal disorders and awareness of physiotherapy management among the primary school teachers. Study Design: Non-experimental. Subjects: 340 samples. Permission from the Institutional head along with the concerned teachers was taken initially to conduct the study. Prior information about the study was given. The purpose of the study was explained to all the subjects to take part in the study. The subjects were selected based on the inclusion and exclusion criteria. Then the “Extended Nordic musculoskeletal questionnaire’’ and the “Physiotherapy...
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Posted by admin on May 31, 2017 in |
Objective: Underreporting of adverse drug reactions (ADRs) is the major drawback encountered in the pharmacovigilance programs. Inadequate knowledge and skill about pharmacovigilance among the health care professionals are the major reasons for underreporting of ADRs. This study was done to assess knowledge, attitude and practice (KAP) of undergraduate medical students about pharmacovigilance as they are the future health-care givers. Materials and Methods: This cross-sectional, questionnaire-based study was carried out to evaluate KAP of pharmacovigilance among undergraduate medical students in a Tertiary Care Teaching Hospital of North India. Data obtained from filled questionnaires was thereby analysed. Results: The mean score of 2nd year, prefinal and final year students for knowledge is (7.58, 6.92 and 6.73), for attitude (7.51, 6.91 and 7.23) and for practice is (1.53, 1.68 and 1.52) respectively. There is a significant difference in mean score between three groups for knowledge and attitude, but not for practice. Conclusion: Students have a good attitude but have an inadequate knowledge and poor practice towards pharmacovigilance. For this, pharmacovigilance related activities...
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Posted by admin on May 31, 2017 in |
Background: The objective of this study was to assess drug therapy problems (DTPs) and their predictors among hypertensive patients on follow up at Dil-Chora Referral Hospital, Ethiopia. Methods: Hospital based cross-sectional study involving medical record review was conducted from February-to-April 2015 using a structured questionnaire and this was complemented by a face-to-face interview. Adult hypertensive patients aged ≥18 years who were on follow-up for at least 3-months were enrolled in the study using a convenient sampling method. Data analysis was done using SPSS software version 16.0. Multiple logistic regressions were fitted and odds ratios with 95%CI were calculated to identify factors associated with DTPs. Results: The study included 271 hypertensive patients. Mean age was 57.73±12.13. One hundred sixty three (60.1%) were females. More than half of the respondents (50.6%) had comorbid condition and diabetes was the most common. More than 71% of patients were found to have at least one DTP and the mean number of DTPs per patient was 1.39±1.28. Need additional drug therapy(62.4%) and non-adherence(32.8%) were the...
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Posted by admin on May 31, 2017 in |
The article is dedicated to studying the impact of the cases causing trauma on the self – realization of students. The levels of the self – realization of students who often subject to traumas with different professions and who rarely subject to trauma are distinguished, and the impact of trauma on the level of their emotional tolerance and academic achievements is determined. It is established that there is an important relation between the self – realization of students with the events causing trauma and this relation is more evident at the levels of self – realization. The study shows that the young who are not subjected to a serious trauma have a high self – realization in comparison with others. Though their academic achievement is same, but creativity is higher in the young who are subjected to trauma less and they always think about the individual development. Procedural and content motives dominate in their activity and in reality, expresses itself as doing different work in the direction of self...
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