Posted by admin on Dec 31, 2016 in |
Diclofenac Sodium, being NSAID, its oral administration restricted due to its inherent problems. Hence in the present study, attempt has been made to design oral sustained release once daily matrix tablets of Diclofenac Sodium using combination of hydroxyl propyl methyl cellulose (HPMC) & PEG 6000 and to study the effect of various process and formulation variables like polymer properties and polymer viscosity on in-vitro release of drug. Sustained release tablets of Diclofenac sodium were prepared using different proportion of HPMC 4000 cps and PEG 6000 (F1, F2, F3……..F6). The physical properties of prepared tablets like hardness, friability, weight variation, thickness and drug content were studied and were found to be within the acceptable limits. In-vitro release studies were performed in Simulated Gastric Fluid (SGF) pH-1.2 for two hours and Simulated Intestinal Fluid (SIF) pH-6.8 for subsequent 10 hours by USP-I dissolution apparatus, in 900 ml at 37.5±0.5oC (stirring speed was 70 rpm). As amount of HPMC was increased from 5% to 30%, released rate was decreased. However, no appreciable...
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Posted by admin on Dec 31, 2016 in |
Extended release hydrophilic matrix tablet formulations of cefuroxime axetil were developed and evaluated to observe the effect of different high viscosity hydroxypropyl methylcellulose (Methocel® K100M, K100M CR and K100LV CR) polymers on in vitro drug release. Fifteen different formulations (F1-F15) were prepared by direct compression. The results of the physical parameters and assay were found to be within the acceptable range of USP 36/NF 31. In vitro dissolution of each formulation, suitably compressed with 9.50±1.10 to 13.47±1.29 Kg hardness were performed in 0.07N HCl, distilled water, 0.1N HCl of pH 1.2 and phosphate buffers of pH 4.5 and 6.8 to observe the drug release. The drug release was higher with K100 LV CR polymer (F14, F15) as compare to K100M and K100M CR in 0.07N HCl (74.22%±0.69 for F14 and 83.57%±0.71 for F15) and in distilled water medium (65.19%±0.78 for F14 and 79.66%±1.05 for F15). The drug release rate from tablets containing K100LV CR was effectively controlled by decreasing the polymer concentration from 30-10%. Model-dependent method were used for...
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Posted by admin on Dec 31, 2016 in |
This present work is on method development of assay and related substances of Vardenafil HCl and degradation of drug substance under acid, base hydrolysis and oxidation conditions. Identification of the impurities were done by the UPLC-TOF. Waters LCT Premier time of flight HRMS instrument with 5 ppm accuracy employed for degradation impurity identification. The validation of the method for its impurities was done in RP-UPLC chromatography as per the ICH Q2(R1) guidelines and the validation parameters such as specificity with all the process and degradation impurities, linearity, precision, accuracy, solution stability, mobile phase stability, robustness and ruggedness parameters met acceptance criteria as per ICH...
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Posted by admin on Dec 31, 2016 in |
Periorbital ecchymosis occurs due to head and face trauma, base skull fracture, craniotomy or ophthalmic operations. There are some less common causes including: hematologic disorders (coagulation disorders, thrombocytopenia), vascular disorders (hemangioendothelioma, varicose veins around the eyes), inflammatory diseases (myositis, amyloidosis), skin disorders (herpes simplex), migraine and increased intracranial pressure. In this paper we have presented a 31 years old lady who developed headache, diplopia and unilateral periorbital ecchymosis spontaneously during the 5th week of pregnancy without any history of head and neck trauma or surgery. Ophthalmologic exam, blood pressure and primary lab data were normal. In further evaluations, superior sagittal sinus thrombosis was diagnosed based on to the brain CT, MRI and MR venography results. Therapeutic dose of unfractionated heparin started. Some hemorrhagic complication occurred but disappeared with supportive care. The patient’s symptoms gradually vanished within a week after her admission. Patient continued the pregnancy by using therapeutic dose of low molecular weight heparin without any complications. Pregnancy was terminated by cesarean section in the 38th weeks without any...
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Posted by admin on Dec 31, 2016 in |
Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as intermediate. These intermediates on further reaction with hydrazine hydrate using ethanol as solvent and converted into pyrazoles. The synthesized compounds were characterised by their physical properties, IR, NMR and elemental analysis techniques. The purity of the compounds and completion of reaction was tested by TLC Technique using ethyl acetate and petroleum ether as an eluent (6:4). The antimicrobial activity of synthesized pyrazoles was assessed by Disk diffusion method using gram positive and gram negative strains. The benzoyl and nitroso derivatives were also prepared to confirm the formation of new compounds. The derivative of these compounds also shows good antimicrobial...
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