Posted by admin on Feb 28, 2017 in |
Green nanotechnology is gaining importance due to the elimination of harmful chemicals and provides a safe, environmental friendly and economic method for synthesis of nanoparticles. In the present investigation fruit extract of Leea indica (Burm.f.) Merr. was used for the synthesis of silver nanoparticles. Aqueous fruit extract were added to 1 mm silver nitrate solution by changing the colour of reaction mixture from colourless to brown colour indicates the formation of silver nanoparticles further, confirmed by characteristic UV-Vis absorption peak at 400 nm. Synthesized nanoparticles were characterized by FTIR, EDAX, AFM and HR-TEM. The FTIR data revealed that bio-molecules involved in the reduction and capping of silver nanoparticles. The morphology of silver nanoparticles was determined by AFM and HR-TEM. The size of nanoparticles ranges between 10-50 nm. The EDX analysis confirmed the purity and elemental nature of silver. Synthesized silver nanoparticles exhibited synergistic antimicrobial activity in combination with antibiotic against Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus...
Read More
Posted by admin on Feb 28, 2017 in |
The hydroalcoholic extract of Nyctanthes arbor-tristis (HeNAT) leaf was prepared using Soxhlet apparatus. Memory impairment (amnesia) in male albino rats induced by scopolamine hydrochloride was recorded as transfer latency time (TLT) in EPM model; escape latency time (ELT) and time spent in Q4 target quadrant (TSTQ) in MWM model. Scopolamine markedly decreased the TLT over 2 min, ELT, TSTQ over 90 sec and consecutively impaired learning and memory. HeNAT leaf extract (20 and 40 mg/kg, p.o.) increased the TLT, ELT, TSTQ and improved memory. Higher levels of brain AChE, MDA and NO and lower level of GSH activity were observed in scopolamine treated rats, which were significantly attenuated by HeNAT leaf extract. It is concluded that the leaf extract exhibited a significant nootropic effect in scopolamine induced impairment of memory in rats. Nootropic effect of the plant leaf extract may be mediated through the inhibition of oxidative stress and due to presence of iridoid and phenylpropanoid glycosides which was reported to possess anti-cholinesterase...
Read More
Posted by admin on Feb 28, 2017 in |
Lead is important heavy metal and due to widespread use in industry, it has become an important pollutant that exerts toxic effects on human health. Lifestyle factors (e.g. cigarette smoking), proximity to industrial areas, lead mines, lead based paints and leaded gasoline significantly contribute to lead pollution of the air, food, water and soil. Several antioxidant enzymes and molecules have been used to evaluate lead–induced oxidative damage. Present study aimed to evaluate the lead acetate induced cardio-toxicity. Lead acetate is known to induce changes in free radical scavenging enzymes like superoxide dismutase (SOD) and catalase (CAT). Healthy looking mice showing no sign of morbidity were divided into three groups. Group I was designated as control whereas group II and group III received lead acetate having doses 10 mg/kg body weight of lead acetate, daily and 150 mg/kg body weight of lead acetate, weekly respectively. Study was performed after 24 hours, 40 and 80 days stages. Lead acetate significantly decrease antioxidant enzymes and increase oxidative stress along with cardiac tissue...
Read More
Posted by admin on Feb 28, 2017 in |
The rationale of the present study was to formulate & optimize the floating Bupropion HCl microsponges by 23 factorial design. The concentration of ethyl cellulose (EC), polyvinyl alcohol (PVA) and Dichloromethane (DCM) were selected as independent variables. Floating lag time & % drug release were selected as independent variables. Factors, their levels (with values) were substituted in the design of experiment software (Sigma tech version 3.1). The effect of factors at different levels on response variable was predicted using poly nominal equations. FTIR studies revealed that no chemical interaction between drug & polymer used. DSC confirmed molecular dispersion of drug in the microsponges polymer matrix. Quasi emulsion solvent diffusion method was used to formulate microsponges. Bupropion HCl showed acceptable flow. The morphology of microsponges was studied using SEM and it was found that microsponges were spherical and porous. USP Type II dissolution apparatus with cellophane membrane was used to study in vitro drug release. Kinetic studies revealed that drug release from optimized formulation followed Higuchi’s model and diffusion is...
Read More
Posted by admin on Feb 28, 2017 in |
In view of therapeutic values associated with Syzygium cumini and increasing consumer demand for functional foods, a non-conventional alcoholic beverage prepared from the stem of Syzygium cumini was evaluated for its efficacy against streptozotocin-induced diabetes mellitus in male wistar rats. The beverage was observed to be safe for consumption as it did not produce any anomalies in the biochemical markers of liver and kidney of normal rats, rather exerted protective effects on hepatic and renal functions by improving the levels of biochemical indicators. After an oral administration of a daily single of dose of 4ml/kg for a period of 30 days, stem beverage was able to rectify the abnormalities in blood glucose levels, lipid profile and atherogenic index of diabetic rats. The beverage also arrested the deviations in hepatic and renal functions of diabetic rats. Histological studies of pancreas also confirmed the anti-diabetic behaviour of stem beverage. The pharmacological properties of the beverage can be ascribed to the presence of various phenolics and tannins in it. The use of...
Read More
