Posted by admin on Dec 31, 2016 in |
Essential oils extracted from two Algerian endemic plants Lavandula antineae and Thymus algeriensis were analyzed by the GC, the results showed the presence of a large amount of oxygenated sesquiterpenes in both species. Total phenolics and flavonoids content were determined according to the Folin-Ciocalteu method and the aluminum trichloride method, the antioxidant activities of two types of extracts (ethyl acetate and n-butanol) from the plants were tested with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The rates of total phenolics and flavonoids present in L. antineae equal to 2,013± 0,009 mg GAE / g of dry plant and 0.587± 0,003 mg QER / g of dry plant material respectively. Thymus algeriensis has presented values of phenolics and flavonoids equal to1.337± 0,001 mg GAE / g and 0.339± 0,001 mg QER / g of the dry plant. The ethyl acetate extract of L. antineae have presented the higher EC50 value...
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Posted by admin on Dec 31, 2016 in |
Sunscreens aid the body’s natural defense mechanisms to protect against harmful UV radiation from the sun. The present study involves the formulation of sunscreen cream with herbal active ingredients and evaluation for its effectiveness. Naturally occurring traditional substances are gradually replacing synthetic counterparts due to their effectiveness and absence of adverse effects. The herbal drugs selected for the study were roots of Glycyrrhiza glabra Linn. (Yashtimadhu), Hemidesmus indicus R.Br. (Anantmul) and heartwood of Santalum album Linn. (Chandana). Creams were prepared with each individual herb and combination of all three herbs with varying concentration of herbal extracts. The evaluation included determination of Sun Protection Factor for all the formulated creams. The SPF was calculated using the spectrophotometric method and then applying the Mansur equation. The results of the study indicated that the 25% combination cream showed maximum sun screeening...
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Posted by admin on Dec 31, 2016 in |
Aim: Labetalol is useful in severe hypertension (HT) in pregnancy; however, there was a need to define its role in mild HT in pregnancy. The present study was done to evaluate efficacy of labetalol in mild HT in pregnancy, compare it with that of methyldopa, and compare the tolerability of methyldopa and labetalol in patients. Methods: A prospective drug comparative study was conducted for one year in 60 mild hypertensive pregnant women, with gestational age of ≥20 weeks, receiving either labetalol or methyldopa. The primary endpoint was control of blood pressure (BP). The parameters recorded for comparison were time and dose to control BP, dose escalation, urine albumin level, adverse effects, and pregnancy outcomes. Results: Both the drugs produced significant reduction in BP in the patients (p<0.001). The patients in both groups showed significant reduction of urine albumin. Same number of patients in both groups required dose escalation. Time to control BP was less in the patients receiving methyldopa than those receiving labetalol; however, the patients receiving labetalol reported...
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Posted by admin on Dec 31, 2016 in |
Mango products are well demanded by consumers due to their unique flavor and mango pulps are developed as various products while mango peels and seeds are the major agro-industrial wastes in canned fruit manufacture and fruit juice processing. Hence the aim of the present study was to investigate on their bioactive phenolic compounds in mango byproducts. Extracts of pulps, seed kernels and peels were prepared using ethyl acetate. Total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity and the anti-inflammatory activity were evaluated. The higher TPC was observed in the peels (52.67-275.61 mg GAE/ g of extract) and the seed kernels (132.95-270.56 mg GAE/ g of extract) than that of the pulp while the highest TFC was present in the pulps (120.20-479.80 mg QE/g of extract). The extracts of mango seed kernels and peels exhibited greater antioxidant activity on DPPH, ABTS, NO, FRAP assays and higher anti-inflammatory activity with IC50 values of seed kernel and peel extracts were found in the range of 7.73-222.10 µg/mL and 11.86 to...
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Posted by admin on Dec 31, 2016 in |
Objective: To Evaluate hypoglycemic effect of Roflumilast in streptozotocin induced diabetic albino wistar rats. Materials and Methods: 18 albino rats were divided into 3 groups each group containing 6 animals, Group-1 (Diabetic Control): Distilled water 10ml, Group-2 (Standard): Glibenclamide 1.35mg, Group-3 (Test): Roflumilast 0.045mg/kg. A freshly prepared solution of Streptozotocin (45mg/kg body weight) in 0.1ml citrate buffer, pH 4.5 was injected intraperitoneally in a volume of 1ml/kg body weight to overnight fasted rats. After 48 hours of STZ administration, rats with moderate diabetes were selected for the experiment. A base line Capillary Blood Glucose was checked just before giving streptozotocin. All along the course of study animals were provided with water and food ad libitum. On the 3rd day animals were evaluated for the diabetic status by checking CBG. Only diabetic rats were used for further study. They were given above drugs for a period of 28 days starting from 3rd day after giving streptozotocin. Blood glucose levels and body weight were measured on 0, 7th, 14th, 21st and...
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