Posted by admin on Jan 31, 2017 in |
Colonization of bacteria causes various diseases of oral cavity such as plaque and gingivitis. Staphylococcus and Streptococcus species are the most important pathogens causing dental caries. The present study was designed to screen the anti bacterial action of four different marketed mouth washes namely Listerine zero, Colgate plax, Signal expert protection and Aloe dent against selected human pathogenic strains Staphylococcus aureus, Streptococcus pyogenes, Bacillus subtilis and Escherichia coli. All the brands of mouth wash demonstrated an excellent spectrum of activity against Staphylococcus aureus. In this study the antibacterial action of Listerine zero was significant when compared to Colgate plax against Staphylococcus aureus at P < 0.05 level. However, the spectrum of action of Colgate plax was extremely significant against Bacillus subtilis at P< 0.001 level when compared to rest of mouthwashes screened. The spectrum of activity varied with brands of mouth washes screened against organisms. This study demonstrated that all the brands of mouth washes revealed good anti bacterial...
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Posted by admin on Jan 31, 2017 in |
The complexes of Cu(II) and Ni(II) having the general composition ML2X2 (where L= 2-benzoylpyridine thiosemicarbazone, M=Ni(II),Cu(II), and X=Cl–, NO3–,SO42-, OAc–) have been synthesised and were characterised by IR, elemental analysis, magnetic susceptibility, UV-Vis, conductivity, mass spectrometry and EPR spectral studies. The IR spectral data indicates that the ligand behave as a bidentate ligand and coordinated to the metal ion through its nitrogen and sulphur donor atoms. The ligand is highly soluble in water. On the basis of molar conductance value which was determined by using DMSO as solvent it can be concluded that all the complexes were non electrolytic in nature. The value of magnetic moment indicates that all the complexes are of high spin type. On the basis of spectral studies an octahedral geometry has been proposed for Ni(II) complexes while tetragonal geometry was proposed for Cu(II)...
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Posted by admin on Jan 31, 2017 in |
The objective of this research was to develop and characterize floating microspheres of esomeprazole magnesium trihydrate by solvent evaporation method using various polymers. The esomeprazole magnesium trihydrate floating microspheres was successfully developed by solvent evaporation method using HPMC, CA, Carbopol 940, Eudragit L 100 in various proportions. Further, the prepared floating microspheres were characterized for particle size, morphology, micrometric studies, entrapment efficiency, in vitro drug release, release kinetics, compatibility studies (FTIR), SEM and DSC studies. The EMT microspheres were free-flowing. The mean particle size ranged from 100.08±0.95 to 500.42±1.03μm and the entrapment efficiency ranged from 67.11±3.01 to 96.38±2.34%. SEM revealed a hollow spherical structure of microspheres with a smooth surface morphology and the internal surface was porous due to the evaporation of solvent entrapped within the shell of microspheres. The IR Spectrum obtained from EMT and polymers were identical and there was no change in the functional group absorption of any molecule present in formulated product. Formulation F9 was found to be highest in-vitro buoyancy 94.95±1.43. Amongst the formulation,...
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Posted by admin on Jan 31, 2017 in |
Rheumatoid arthritis (RA) is a chronic inflammatory disease, affecting 1-2% population worldwide. RA is common among the women in comparison to men. The disease mostly affects the age group 45 onwards, while juvenile cases are also reported. Exact pathogenesis of the disease is still a question. Studies indicate RA as an overabundance of pro-inflammatory cytokines, and inadequate anti-inflammatory cytokines. TNF-α, IL-1β, and IL-6 are established pro-inflammatory cytokines and IL-10 as anti-inflammatory cytokine in several autoimmune and inflammatory diseases. Crocus sativus is considered as an anticonvulsant, antidepressant, antispasmodic and diaphoretic agent and Nyctanthes arbortristis has been known for its anti-helmenthic, anti-bacterial activity etc. The present study was designed to evaluate the effectiveness of Crocus sativus (CS) and Nyctanthes arbortristis (NAT) towards anti-inflammatory property in inflamed animal tissue. We induced arthritis by injecting Freund’s complete adjuvant in the paw of mice. Water soluble ethanolic extract of Nyctanthes arbortristis (leaf) and Crocus sativus (stigma) was administered orally to adjuvant induced arthritic mice at the dose of 23.72 and 100 mg/kg body weight,...
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Posted by admin on Jan 31, 2017 in |
Background: RA is an autoimmune disease triggered by faulty immune system and affects various joints of body including wrist and finger. Nowadays slow acting or DMARDs (Disease modifying anti-rheumatoid drugs) are mainstay of treatment in RA. HCQs belong to this group. They are slow acting so they take weeks to months to become effective. HCQ is less effective when compared to gold or penicillamine but its tolerance is better than other DMARDs. Objective: 1. To observe a dose–response relationship for hydroxychloroquine (HCQ), in terms of the proportion of patients achieving the Paulus 20% criteria for improvement in patients with rheumatoid arthritis (RA) receiving a 24 week loading regimen of 400, 800, or 1,200 mg HCQ daily. 2. To investigate possible relationships between increased dosage of HCQ and measures of efficacy and toxicity. Methods: 422 Patients with RA began a 24-week study comparing 3 different doses of HCQ at 400, 800, or 1,200 mg/day, followed by 18 weeks of open-label HCQ treatment at 400 mg/day. Patients were evaluated at 0,...
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