Posted by admin on Jul 31, 2024 in |
This study aimed regarding application of comprehensive stability-indicating analytical method for estimation of Escitalopram impurities in multiple brands of pharmaceutical dosage forms using reverse phase high-performance liquid chromatography. The comprehensive stability-indicating analytical method applied utilized an isocratic mode with a C18 column. The mobile phase comprised a phosphate buffer and acetonitrile (75:25v/v) at a flow rate of 1.2ml/min. A sample injection volume of 5μL was employed, and eluted analytes were monitored at 240nm. The utilized method was validated following ICH guidelines and found to be simple, specific, highly sensitive, precise, robust, and linear for Escitalopram in the range of 0.16 to 2.4μg/ml. Similarly, for Escitalopram impurities A, B, D, H, L & C, the observed linearity range was 0.25 to7.5μg/ml. Accuracy range was confirmed for Escitalopram from 0.16 to 2.3μg/ml, Escitalopram impurities A, B, H from 0.3 to 8μg/ml, and Escitalopram impurities C, D, and L from 0.5 to 8μg/ml. The solution demonstrated stability for up to 48 Hrs. Additionally, the applied method was proven to be stability-indicating by...
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Posted by admin on Jul 31, 2024 in |
Setaria italica L. is one of the world’s oldest crops, which has been cultivated and domesticated about 8000 years ago. It is known for its ecological, nutritional and medicinal properties. In Ayurveda, it is called kangu/priyangu and is believed to nourish the body tissues and absorb excessive fluids besides, widely used in the treatment of various disorders. Since, no reports are available on microscopical and phytochemical studies of the caryopsis of Setaria italica L., hence, the present study was undertaken to investigate the same. Pharmacognostic and preliminary phytochemical study of the caryopsis of Setaria italica L. were carried out using microscopy, physicochemical analysis and TLC. The microscopy shows the presence of tube cells and cross cells, starch grains devoid of hilum, and occurring singly or in aggregates, tangentially elongated cells of pericarp, and endospermic cells filled with aleurone grains. The physicochemical analysis shows 8.33% w/w LOD, 3.10% w/w, Ash value and 7.83pH.TLC did not show any colour at UV 254 and 366 nm however, three brownish colour bands of...
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Posted by admin on Jul 31, 2024 in |
The purpose of this research was to examine the development of a mouth-dissolving tablet formulation of omeprazole to enhance its rapid absorption through the buccal mucosa, which would facilitate the onset of therapeutic effects more quickly. Formulation was difficult for omeprazole because of its low solubility and permeability, which places it in the IV class of drugs according to the Biopharmaceutics Classification System. For the preparation of the tablets, the wet granulation method was utilized, which ensured that the drug-excipient ratios were consistent throughout. All of the formulations were able to satisfy the pharmacopeial standards for weight consistency, friability, thickness, and drug content. The results of the in-vitro tests showed that the disintegration and dispersion properties were outstanding, which indicated that the bioavailability and drug release kinetics were more favorable. Over four weeks at a temperature of 50℃, accelerated stability testing indicated consistent drug content, hardness, and in-vitro dispersion time. This indicates that the formulation has been stable for more than a year. Because the newly created formulation shows...
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Posted by admin on Jul 31, 2024 in |
Rheumatoid arthritis (RA) is one of the most prevalent chronic inflammatory joint diseases which affect approximately 1% adult population in the worldwide. Polyherbal ayurvedic formulations (Munipayn and Rumalaya forte) reported to be effective as anti-inflammatory and anti arthritic activity. In-vitro anti-inflammatory of individual formulations (Munipayn and Rumalaya forte) were evaluated by albumin denaturation and Red blood cell membrane stabilization assay methods. In-vivo anti-arthritic activity of Munipayn (25 mg/kg and Rumalaya forte 40 mg/kg, bw, po) were evaluated against Frund’s complete adjuvant induced arthritis in rats. After the injection of FCA, the polyherbal formulations, standard was administered for 28 days. Both the formulations and standard showed a significant (P<0.001) reduction in paw volume, paw thickness, increase in WBC when compared to FCA treated rats. Histological reports also suggested that histological changes reversed in both formulations treated rats. Present study resulted that Munipayn and Rumalaya forte has significant anti-inflammatory, anti-arthritic activity against FCA-induced arthritis...
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Posted by admin on Jul 31, 2024 in |
Background: Diabetes mellitus (T2DM) is a disorder in which the amount of sugar in the blood is elevated. Doctors often use the full name that is Diabetes Mellitus rather than Diabetes alone to differentiate from Diabetes Insipidus. Diabetes Insipidus is a relatively rare disorder that does not affect the blood glucose levels but just like Diabetes Mellitus, causing increased urination. Method: A prospective observational study was carried out among T2DM patients. Patient demographics, medication details, and blood glucose levels were recorded, examined, and the prescription pattern of the doctors was analyzed. Result and Discussion: The study included 209 T2DM patients. Metformin was more frequently prescribed single drug in 7.60% of participants. Dual drug combinations were Metformin and Glimepiride (49.04%), Metformin and Dapagliflozin (4.56%), Metformin and Vildagliptin (6.84%). About 61.84% were prescribed with short-acting insulin, 26.31% with intermediate-acting insulin, 10.52% with long-acting insulin, and only 1.31% of participants were prescribed with rapid-acting insulin. Dual drug fixed dose combination, Metformin is commonly combined with Glimepiride. A unique combination encountered was Remogliflozin...
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