Posted by admin on Dec 31, 2023 in |
A simple, novel, precise, rapid, accurate, specific reverse phase high performance liquid chromatography (RP-HPLC) method for estimation of Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate API in marketed formulation was developed and validated. The separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 m) column using an acetonitrile: 3.5 pH Potassium dihydrogen phosphate buffer (60:40 v/v) mobile phase. The flow rate was 1 mL/min, and the UV detector was set to detect at 227 nm. Teneligliptin Hydrobromide Hydrate retained 2.37 min, while Dapagliflozin Propanediol Monohydrate retained 3.61 min. Teneligliptin hydrobromide hydrate revealed a linear response in the concentration range of 10-30ppm. In the concentration range of 5-15ppm, dapagliflozin propanediol monohydrate demonstrated a linear response. Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate had correlation coefficients (‘R2‘ value) of 0.999 and 0.992, respectively. Various validation parameters were used to validate the analysis results. Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate percentage recoveries vary from 98% to 101%. Both precision and robustness study found to have % RSD...
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Posted by admin on Dec 31, 2023 in |
Medicinal plants are enriched with biological substances that are proven to be a direct or indirect source of modern drugs. The relevance of the exploration of new natural reservoirs of pharmaceutical potential has increased immensely after COVID-19. The present study deals with the extraction of flavonoids from selected plants i.e. Ricinus communis, Euphorbia hirta and Croton bonplandinum from the family Euporbiaceae by following conventional and non-conventional techniques. The conventional and non-conventional method includes Soxhlet extraction and Ultrasonic Assisted Extraction, respectively. Significant and comparable results were obtained for the ultrasonic technique in terms of the total quantity of extracts. The quantity of total flavonoid extract from the root, stem of Ricinus communis and stem, fruit, and root of croton bonplandinum is much greater in UAE (4.8mg/gdw and 36.9mg/gdw, respectively; 8.9mg/gdw, 60.5 g/gdw, 10.7 mg/gdw respectively) than Soxhlet method (0.95 mg/gdw and 4.8 mg/gdw respectively; 0.99 mg/gdw, 13.54 mg/gdw and 1.29 mg/gdw, respectively). The higher quantity of total flavonoids was recorded to be more for all extracts of Euphorbia hirta by...
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Posted by admin on Nov 30, 2023 in |
Neoadjuvant chemotherapy with Gemcitabine/nab-paclitaxel (Gemcitabine + Nab-Paclitaxel) And Folfirinox (Folfirinox) are two standard therapies for patients who has locally advanced pancreatic cancer (Lapc). We retrospectively compared the efficacy and safety of the two treatment regimens in patients with unresectable pancreatic cancer. The sample size consisted of 96 patients who has locally advanced pancreatic cancer. (Gnp) Gemcitabine and nab–paclitaxel is Group I (N=53), and Folfirinox consisting of leucovorin, fluorouracil, irinotecan and oxaliplatin is Group II (N=43). The Primary objectives of our study were to compare toxicities between gemcitabine + Nab-Paclitaxel And Folfirinox and to evaluate the safety of these regimens The secondary objective was % reduction of tumor, Surgery (% of patients who underwent surgery) and overall survival both estimated using the independent t- test and chi-square test. Results: The haematological toxicities rates were similar between the two groups (62% vs. 63%; p > 0.05), with similar anemia toxicities rates (62%). The neutropenia toxicity rates were similar (15% vs 16%; p>0.05) and febrile neutropenia, thrombocytopenia, and GI toxicities were higher...
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Posted by admin on Nov 30, 2023 in |
Polycystic ovarian syndrome (PCOS) known by its name can be correlated with Soothaga Vaayu in Siddha classical literature which is one of the most common forms of metabolic and endocrine disorders of women, with a high prevalence among the reproductive age group, often associated with obesity, hypertension, insulin resistance, diabetes mellitus, hyperinsulinemia and dyslipidemia. Current therapeutic management available for PCOS is only moderately effective in controlling symptoms and preventing some of the complications. Hence in recent times, people rely most on alternative complementary treatments for the management of PCOS. The research articles have shown the following bio-active compounds present in the selected herbs used in the Siddha treatment for gynecological problems as Campesterol, Diosgenin, Cinnamic acid, Anethole, Kaempferol, Ferulic acid, Myricetin, Erysovine, β-Sitosterol and Rutin. Molecular docking is a great approach in current trends to identify the possibility of pharmacological effects of medicinal compounds which could be exerted over their corresponding protein targets which are relevant for the disease. Docking simulations were performed using the Lamarckian genetic algorithm (LGA)...
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Posted by admin on Nov 30, 2023 in |
Background: Bhāraṅgī, herbal drug used in Ayurveda as Kapha–Vata samaka and indicated in Swasa, Kasa, Vrana, Shotha etc. It is an important ingredient in many of the preparations like Kantakaryavaleha, Kanakasava, Dasamularista, Lodhrasavam, Sudarsanasavam. As per API the accepted source of Bhāraṅgī is Rotheca serrata (L.) Steane & Mabb belongs to family Lamiaceae. There were ambient studies in which it was found that roots of Bhāraṅgī had been adulterated with stem of the same in the market. But there were no published works indicating the presence of adulterants in the Kerala market, hence this study was proposed to assess the genuineness of raw drug available in the name of Cheruthek (Bhāraṅgī) in different Kerala markets with the root of genuine source plant R. serrata. Materials and Methods: Fresh root of Bhāraṅgī (Rotheca serrata (L.) Steane & Mabb) are collected from the natural habitat. The market samples of Cheruthek were collected from six different regions in Kerala. All samples were screened for pharmacognostic parameters- macroscopic, microscopic, histo-chemical and powder microscopic...
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