Posted by admin on Jan 31, 2017 in |
The aim of the present work was to develop a new microbeads system for colon-targeted delivery of celecoxib. The ternary system were develop using PVP (polyvinylpyrrolidone) and hydroxypropyl-β-cyclodextrin (HPB) to increase solubility of celecoxib. DSC and XRD results confirmed formation of amorphous celecoxib complex with HPB. Chitosan and pectin were used for the development of microbeads of new amorphous celecoxib. Calcium chloride was use as cross linking agent for electrolyte complexation between polymers. Eudragit RS100 was used to embed into microbeads in order to avoid premature delivery of a drug in acidic environment of stomach. Statistical design of experiment was employed to investigate the combined effect of three formulation variables, i.e., % of chitosan, pectin, and CaCl2, on responses like drug release pattern in acidic dissolution medium (CDR in UGIT), colonic dissolution medium with fungus culture of Aspergillus niger (CDR in LGIT) and drug entrapment efficiency (EE%). Response surface methodology was used to analyze multivariate approach for understanding the multifactorial relationships among formulation parameters. Full central composite design was...
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Posted by admin on Jan 31, 2017 in |
Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were randomly divided into five groups (n = 6) and treated as per treatment protocol with three different dose of Ginkgo biloba extract (125, 250, and 500 mg/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with Isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group II) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Ginkgo biloba extract in all three dose (group III, IV and V) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes ( reduced glutathione (GSH), superoxide dismutase (SOD)...
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Posted by admin on Jan 31, 2017 in |
Introduction: Pharmaceutical care entails the work of addressing patient’s medication related needs and problems. The involvement of the pharmacist in India in this regard has been somewhat restricted, contrary to trends in developed countries. Materials and methods: Questionnaire-based explorative, semi-quantitative study involving Doctors, Pharmacists and Nurses of the study department in the following sequence; Design of questionnaire, Pre-testing/validation, Administration, Collection, Evaluation & Interpretation. Results: Out of total 90 questionnaires distributed among health care providers the response rate was measured as 63.3% and less than 40% of the Health Care Providers could answer correctly to the first section of questionnaire intended to assess the knowledge regarding pharmaceutical care. In the perception part 73.3% of doctors agreed and 20% strongly agreed that pharmaceutical services provided by clinical pharmacist can improve the quality of patient care in hospital settings. 66.6% agreed and 26.6% strongly agreed that clinical pharmacist as a part of medical team will minimize medication errors. 73.3% agreed and 20% disagreed that doctors can allow pharmacists to be available with...
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Posted by admin on Jan 31, 2017 in |
In the present study, pharmacognostical, qualitative and quantitative phytochemical analysis of Azardirachta indica, Cassia auriculata, Moringa oleifera and Curcuma longa was done. The results showed the presence of various vital secondary metabolites. Primary metabolites was found to be more in Cassia auriculata whereas the secondary metabolites content was higher in Azardirachta indica. In the selected plants, the alkaloid content was found to be high followed by flavonids, proline. This proves that, the selected plants posses good medicinal property and can be recommended for treatment of...
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Posted by admin on Jan 31, 2017 in |
The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) due to its low solubility and first- pass metabolism. So, nanoemulsion of nimodipine increase its solubility and enhance its oral bioavailability. Pseudo -ternary phase diagrams were made by using aqueous titration method. Nanoemulsions of pseudo-ternary phase diagrams composed of S mix (mixture of surfactant and co- surfactant), oil and deionized water. These nanoemulsions subjected for thermodynamic stability tests in order to select optimized formulations. Nimodipine nanoemulsions were subjected for characterizations studies in order to select the optimized formula. The characterizations studies explain that the optimized formula NE5 composed of 0.6% of nimodipine, 25% of S mix (2:1) that mean (16.66% tween 20: 8.33% PEG400), 10% of oleic acid and 64.4% of deionized water. The optimized formula NE5 characterized by droplet size (50 – 81.2 nm), polydispersity index (0.01), pH value (6.51), higher zeta potential (- 45.6 mV), drug content...
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