Posted by admin on Dec 31, 2016 in |
Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, anticancer effects. The present study aims to determine the effect of Musa paradisica on serum and tissue superoxide dismutase (SOD) levels and the histology in carbon tetrachloride (CCl4)-induced liver injury. Wister rats aged were injected Intraperitoneally with 50% CCl4 in olive oil. Musa paradisica was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured and Histological changes of liver were examined by microscopy. Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with ethonolic whole plant extract of Musa paradisica. The present study demonstrates that Musa paradisica possesses hepatoprotective effects against CCl4– induced hepatotoxicity and that the effects are both preventive and curative. Musa paradisica should have potential for developing a new drug to treat liver...
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Posted by admin on Dec 31, 2016 in |
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedones, open and closed) lesions. A lot of factor viz; hormone, increased sebum production and diet causes Acne vulgaris but bacteria are the chief causal organism in which Propionibacterium acnes and Staphylococcus epidermidis are considered as the major skin bacteria that cause the formation of acne. The present study was conducted to evaluate the in vitro antimicrobial activities of Psidium guajava L. leaves essential oil against Propionibacterium acnes and Staphylococcus epidermidis. Extraction of essential oil was carried out using Clevenger’s Apparatus. Antibacterial activities of essential oil of leaves were investigated using broth micro dilution methods recommended by CLSI. The results showed that Guava leaves oils more effectively inhibit the growth of P.acnes (MIC: 0.321, IC50:0.309 mg/ml) as compared to S. epidermidis (MIC: 0.486, IC50:0.416 mg/ml). The readings were compared by standard drug...
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Posted by admin on Dec 31, 2016 in |
Background: India is highest tuberculosis (TB) burden country accounting for approximately 20% of global TB burden. To tackle this problem, Revised National Tuberculosis Control Programme (RNTCP) based on the DOTS (Directly Observed Treatment Short course) strategy has been made available in the entire country by March 2006. Present study describes the achievements under RNTCP in terms of treatment outcomes, smear conversion rate and evaluation of risk factors for unsuccessful treatment outcome at district tuberculosis centre. Objectives: Treatment outcome of tuberculosis (TB) patients on DOTS (category 1& 2) and evaluation of predictors for unsuccessful outcome. Methodology: A record- based retrospective study; analysis of cases registered for treatment for Cat -1 & 2 at district tuberculosis centre during 2013 & 2014 was done. Data regarding demographic profile, TB type & categories, investigation, treatment outcome and co morbidity were recorded. Data were analyzed and appropriate statistical test was done using Epi info 7, CDC. Result: Out of 1340 registered cases, 1081 (80.67%) were of cat1 and 259 (19.33%) were of cat-2 TB. ...
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Posted by admin on Dec 31, 2016 in |
Simultaneous estimation method for Norfloxacin and Tinidazole in tablet dosage form had been developed by RP- HPLC. Both the drugs come under the category of antimicrobials and prescribed frequently in combination. The developed method is a gradient method which gives retention time of Norfloxacin and Tinidazole as 3.8min and 4.8min respectively. The separation was carried out on Supelco C18 (25cm × 4.6mm, 5µ) column using 0.05M phosphate buffer (pH 3 adjusted with ortho- phosphoric acid) and acetonitrile as a mobile phase. The flow rate was 0.8mL/min and wavelength used was 300nm. The method was validated as per ICH guideline and found to be linear between the range of 1- 6µg/mL for Norfloxacin and 1.5- 9µg/mL for Tinidazole. The developed method was found to be rapid, accurate and reproducible and therefore can be applied for simultaneous estimation of both the drugs as API or tablet dosage form...
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Posted by admin on Dec 31, 2016 in |
Essential oils extracted from two Algerian endemic plants Lavandula antineae and Thymus algeriensis were analyzed by the GC, the results showed the presence of a large amount of oxygenated sesquiterpenes in both species. Total phenolics and flavonoids content were determined according to the Folin-Ciocalteu method and the aluminum trichloride method, the antioxidant activities of two types of extracts (ethyl acetate and n-butanol) from the plants were tested with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The rates of total phenolics and flavonoids present in L. antineae equal to 2,013± 0,009 mg GAE / g of dry plant and 0.587± 0,003 mg QER / g of dry plant material respectively. Thymus algeriensis has presented values of phenolics and flavonoids equal to1.337± 0,001 mg GAE / g and 0.339± 0,001 mg QER / g of the dry plant. The ethyl acetate extract of L. antineae have presented the higher EC50 value...
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