Posted by admin on Nov 30, 2023 in |
Introduction: Endothelial dysfunction and diet-induced diabetes may be significantly impacted by changes in Adipokine and inflammatory cytokine secretion linked to obesity. Our study’s objective was to determine the effect of a high-fat diet also on concentrations of leptin, adiponectin, as well as other inflammatory indicators in type 2 diabetes mellitus brought on by streptozotocin (STZ)-induced endothelial dysfunction (T2DM). Material and Method: This study examined how endothelial dysfunction rats responded to a high-fat diet and Streptozotocin by producing more adipokines and inflammatory cytokines. The 32 rats of four groups of adult male Wistar rats utilized in this investigation were as follows: group 1 received the diet that was 60% fat (HFD) (n = 8); group 2 received a high-fat diet plus, STZ (STZ-HFD) (n = 8); as well as group 3 received a normal diet plus, STZ (STZ-ND) (n = 8). The fourth groups ate a normal diet for six weeks. Using a single intraperitoneal STZ injection, (40mg/kg), type 2 diabetes was induced. a 12-hour fast was imposed on all...
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Posted by admin on Nov 30, 2023 in |
In this study matrix tablets of metronidazole were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F9). The mean hardness values were measured for all the formulation using Monsanto hardness tester. The hardness value ranges from 5.2±0.2 to 5.8±0.1kg/cm2. Twenty tablets were randomly selected from each formulation and evaluated. The obtained data were almost uniform. The values of tablets average weight ranging from 549±5 to 558±7mg. All the tablets passed weight variation test as the % weight variation was within the USP Pharmacopoeia’s limits of ±5% of the weight. The % drug content of all the formulated tablets were found within the limit. % Drug content value of drug was within 98.12±0.25% to 99.85±0.18%. The results within the range indicate uniform of mixing. When the regression coefficient values compared, it was observed that ‘r2’ values of first order was...
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Posted by admin on Nov 30, 2023 in |
Background: Traditionally Gloriosa superba is being used as a medicinal plant in outskirts of belagavi, we evaluated and compared the analgesic and anti-inflammatory activities of hydroalcoholic extract of dried aerial parts (rhizomes) of G. superba with standard drugs. Methods: This experimental animal study was carried out in the Research Laboratory, Department of Pharmacology, BIMS, Belagavi. Prior permission from institutional ethical committee and institutional animal ethics committee was taken. Albino rats and Albino mice were used. Acute toxicity study was also done according to OECD guideline no. 425 and test doses were decided accordingly. The experimental models of Eddy’s hot plate method was used to study the analgesic activity whereas formalin induced peritonitis and cotton pellet granuloma models were used for anti-inflammatory action. Statistical analysis was performed using Mann-whitney U test and chi-square test (SPSS software version 22). Results: In eddy’s hot plate method, for G. superba extract of 400mg/kg, percentage increase in reaction time of at 120 mins was 60.49%, in formalin induces peritonitis method, for G. superba extract...
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Posted by admin on Nov 30, 2023 in |
Antibiotic resistance is one of the gravest threats to human health today. Antibiotic resistance has emerged among hazardous bacteria due to the widespread use of drugs for human health, marine life, and agricultural animals. In contrast, bacteriophages are viruses that parasitize other bacteria for sustenance. A host cell is necessary for phage development and may be found practically everywhere in this ecosystem. The emphasis of the research is on the therapeutic application of bacteriophages in the treatment of a Multidrug resistant potential bacterial pathogens isolated from hospital waste and identified as Staphylococcus saprophyticus ATCC 15305, Staphylococcus aureus, Escherichia coli, Pseudomonas sp. populations, as well as determining their MIC90 value against four different antibiotics, are controlled with the use of bacteriophages recovered from waste as well as river water. In addition, the isolated bacteriophages are coated and packed into prepared sodium alginate microsomes. Furthermore, the stability of the microspheres is analyzed artificially under different simulated gastrointestinal conditions (phage titers of 4.7 Log10 PFU/ml to 5.04 Log10 PFU/ml were obtained after...
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Posted by admin on Nov 30, 2023 in |
Consistently the preparation of transition metal complexes of β-diketones has been (and it still is) an area of the highest interest for inorganic and organic chemists, as can be inferred considering the quantity and diversity of research developed in this field. 1,3- Diketones are wide range of valuable molecules including several types of carbocycles and heterocycles hence have high interest. In fact, excessive amount of therapeutical uses are associated with these 1,3- Diketone compounds. The present work is based mainly on the ultrasound irradiation synthesis of various β-diketone ligands and their Fe (III) complexes. At ambient temperature, the clinically active and functionalized various β-diketones has been synthesized from Baker–Venkataraman transformation and its Fe (III) complexes has been prepared and characterized by physical, spectral and analytical data. The different spectroscopic analysis like Mass, 1H-NMR, 13C-NMR, IR, UV and elemental analysis were done. The functionalized beta-diketones showed a certain behaviour and behaved as bidentate ligand and co-ordinate with the transition metal atom through beta-diketo system. The complexes have general formula [ML2]....
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