Posted by admin on Sep 30, 2016 in |
Biofunctionalization of nanoparticles is an advancement of current nanotechnology and biotechnology fields. Developing biocompatible progressive functional materials possess antimicrobial properties could be hopeful for environmentally benevolent applications. Biofunctionalization of nanomaterials is one such topic to produce the non-toxic and more efficient antimicrobial agents. The present study describes a synthesis method of bioactive curcuminaniline functionalized zinc oxide nanoparticles in the eco-friendly methods and comparative studies of those were undertaken against non-functionalized zinc oxide nanoparticles. The synthesis process was carried out through a simple green methodology. Synthesized nanoparticles were analyzed for antibacterial activity by using disc diffusion method against two gram-positive bacteria and two gram-negative bacteria and antifungal activity by using agar well diffusion method against four funguses. Synthesized materials were characterized by UV- Vis, FT-IR, SEM and TEM techniques. The synthesized zinc oxide nanoparticles were in the range of 46 nm and the biofunctonalized nanoparticles were about 100 nm. The antimicrobial activities of those were showed appreciable inhibition zones against S.typhi, B.subtilis, A.niger and T.simii...
Read More
Posted by admin on Sep 30, 2016 in |
Aim of the present study was to compare antianxiety activity of various extracts of Oats (OA), Rice Bran (RB) and Spinach (SP) which are rich in phenolics mainly flavonoids and possesses excellent antioxidant property. Flavonoids are reported to have effect on central nervous system, mainly in anxiety disorders. The activity of various extracts (petroleum ether and hydroalcoholic) of all the three plants was evaluated at different doses (50, 100, 200 mg/kg of body weight) using EPM model of anxiety. The studies were conducted on swiss albino mice, and the test materials were administered per oral route. Results indicated that out of all the prepared extracts of the three selected plants, hydroalcoholic extract of Spinach (Spinacia oleracea) exhibited maximum and significant effect at 200 mg/kg of body weight, the results were comparable to the standard antianxiety drug diazepam (2 mg/kg...
Read More
Posted by admin on Sep 30, 2016 in |
Fexofenadine Hydrochloride (FHCl) is a second generation antihistaminic drug which is used in the treatment of allergic rhinitis and urticaria. It is a BCS class II drug and has high first pass metabolism leading to low oral bioavailability. Drug-inclusion complex with 2HPβCD was prepared by kneading method and characterized for solubility study, FTIR study and in vitro dissolution study. Nine different combinations of polymers to be added were generated by Central Composite Design was used to evaluate dependent parameters by varying the independent variables, HPMC E5 and HPMC K4M and responses were tensile strength, mucoadhesive strength and in vitro diffusion. Films were prepared and evaluated for different parameters and found to be in acceptable limits. Optimized formulation F10 generated from the design showed good tensile strength and mucoadhesive strength and optimum in vitro diffusion results. Drug permeation through porcine oral mucosa at the end of 120 mins was 85.59%. Short term stability studies revealed that formulation was stable after storage for 1...
Read More
Posted by admin on Sep 30, 2016 in |
Candesartan Cilexitil is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan cilexitil is a BCS class II drug having low solubility and high permeability. Candesartan Cilexitil is a prodrug which is rapidly converted to the active drug, Candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. The bioavailability of Candesartan Cilexitil is approximately 15% after an oral administration. To increase bioavailability of such drug, solubility and dissolution are important parameters. To increase solubility of candesartan cilexitil, spray drying technique was incorporated with use of Fluidised Bed Processor. Also dissolution rate was improved with the use of appropriate superdisintegrants. Superdisintegrants used are Croscarmellose sodium, Crospovidone and Sodium starch glycolate. Dissolution rate of Candesartan Cilexitil from prepared dispersible tablet was compared with marketed formulation. Results have shown that solubility of Candesartan Cilexitil has been increased and dissolution rate was improved significantly. The transformation of Candesartan Cilexitil from crystalline to amorphous state by spray drying and the use of superdisintegrants are considered among the factors which...
Read More
Posted by admin on Sep 30, 2016 in |
Asteracantha longifolia, Asparagus falcatus, Vetiveria zizanioides, Coriandrum sativum and Epaltes divaricate have proven hepatoprotective and antioxidative effects against carbon tetrachloride and paracetamol induced hepatotoxicity in mice and are widely used in Sri Lanka for the treatment of liver disorders. However, toxicological information regarding their safety after exposure to experimental animals or humans is not available. The present study was designed to evaluate repeated dose toxicity of the five aqueous extracts mentioned above. Healthy, ICR mice were treated with 0.9g/kg (orally) of aqueous extracts daily, for a period of 30 days. Animals were observed for effects on body weight, food consumption, external appearance and mortality. Biochemical, haematological and histopathological parameters were estimated in all groups at the end of 30 days. Aqueous extracts tested didn’t produce mortality, changes in behaviour, difference in body weight, feeding habits or any other physiological activities in mice, at the dose administered. Biochemical or haematological analysis showed no marked differences in any of the parameters examined in either the control group or in the plant...
Read More
