Posted by admin on Aug 31, 2016 in |
This project involves in the development of sustained release matrix tablets of Gemigliptin. Which is an oral anti-hyperglycemic agent designed for the management of non insulin dependent diabetes mellitus (NIDDM). The basic goal of therapy is to achieve a steady sate blood level that is therapeutically effective and non toxic for an extended period of time. The objective in dosage form design is to optimise the delivery of medication to achieve the control of therapeutic effect in the face of uncertain fluctuation in the in-vivo environment in which drug release takes place. Eight formulations of Gemigliptin 50mg were formulated by admixing with HPMC K4M, Carbopol were used as rate controlling polymers in different concentrations, Micro crystalline cellulose, Lactose, Talc, Magnesium stearate. Pre-formulation and post-formulation studies were carried out and the values obtained, satisfies the pharmacopoeial specifications. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics. Of all the formulations F5 exhibited gradual and completion extended release for Gemigliptin. The F5 (carbopol) with 1:1...
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Posted by admin on Aug 31, 2016 in |
The purpose of present study was to design and evaluate matrix tablets of Matrix tablets of Diltiazem hydrochloride were prepared by using natural polymers like Gum karaya and Gum kondagogu. The pre formulation study was performed on combination of drug with polymers by FTIR suggested that drug and polymers were compatable. The matrix tablets were prepared by using by wet granulation method. All the prepared tablets were evaluated for weight variation, hardness, friability, drug content uniformity and in vitro drug release characteristics. The formulation F4 shows the 99.75% of drug release up to 12 h when compared with all other formulations. Formulation containing diltiazem hydrochloride with gum karaya shows best and maximum drug release of 99.75% up to...
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Posted by admin on Aug 31, 2016 in |
In some disease like thalassemia major long-term transfusion alone inexorably produces the clinical problem of iron overload. Danshen and Milk thistle has been widely prescribed in traditional folk medicine for treatment of liver diseases. In this study we selected eight medicinal plants whose efficiencies had been previously demonstrated in treatment of liver diseases in ancient medicine were studied for their in vitro chelating activity. After preliminary evaluation of these plants in vitro condition, two most efficient plants were nominated for further evaluation in in vivo condition on iron-overloaded mice. The extracts with high iron chelation activity were injected intraperitoneally. Liver sections were stained by haematoxylin and eosin and Perls’ stain. Danshen and Milk thistle had maximum iron chelation activity at in vitro condition. The iron-overloaded mice treated with the extracts showed a significant decrease in plasma iron level and in plasma Fe3+ content. Perl̕ stain improved sensitivity of the test significantly in order to determine the low amount of deposited iron in the liver of iron- overloaded mice treated...
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Posted by admin on Aug 31, 2016 in |
Inula racemosa, Bombax ceiba and Allium sativum are important class of drug known as “Rasayana”. The Polysaccharide fraction of all the three Drugs was isolated from hot water extraction yielding about 50-60% of fructan fraction (Polysaccharide). The polysaccharide fraction was evaluated for immunomodulatory activity by antibody titer and cellular immune response. The immunosuppressant drug azathioprine (100 mg/Kg/body weight) was used in order to evaluate the potency of immunomodulation of fructan fraction of rasayana drugs. The toxicological studies was made and a dose of 1000mg/Kg for Inula racemosa and Bombax ceiba and 1200mg/kg in case of Allium sativum was found to be not toxic. The non specific immunity determined by survival rate against Candida albicans infection was improved after treatment with fructan fraction. An increase in delayed type hypersensitivity response (DTH), % neutrophil adhesion and in vivo phagocytosis by carbon clearance method was observed after treatment with fructan fraction. The Immunostimulant activity of fructan fraction in dose of 200mg/kg of body weight was found to be more effective than 100mg/kg...
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Posted by admin on Aug 31, 2016 in |
A simple, accurate, precise, rapid and economical RP-HPLC method was developed for the estimation of Cefpodoxime Proxetil (CPD) and Levofloxacin hemihydrate (LVX) in tablet dosage form. In Agilent – 1100/1200 Series, using C18 (250 x 4.6 mm x 5μ) column and with mobile phase composition of Phosphate buffer: Acetonitrile (pH 6.0) (50:50 v/v) at a flow rate of 1 ml/min was used. Detection was carried out at 240 nm. Retention time of CPD and LVX was found to be 5.64 & 5.97 min and 2.79 min, respectively. The method has been validated for linearity, accuracy and precision, LOD, LOQ and System suitability according to ICH Q2R1...
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