Posted by admin on Oct 31, 2016 in |
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Prochlorperazine maleate is an anti-emetic drug. It was under goes extensive first pass metabolism resulting in an oral bioavailability of 0 to 16 % and it shows variable absorption from GIT. Hence in the present work Buccoadhesive bilayered tablets of Prochlorperazine maleate were prepared with the objective of avoiding first pass metabolism and controlling the release of drug for prolog period of time. Controlled release buccoadhesive bilayered tablets containing Prochlorperazine Maleate was prepared using a 32 full factorial design. Amount of HPMC K4M CR and Carbopol 974 P NF were taken as the formulation variables (factors) for optimizing Bioadhesive strength and percentage release of drug. The bilayered buccoadhesive tablets were evaluated for Physical characterization, Assay, Swelling index, Adhesion study, In-vitro residence time, Microenvironment pH, In-vitro drug release and In-vitro permeation. The formulation with 5 mg HPMC and 7.5 mg Carbopol was consider as a best product with respect to Adhesive strength,...
Read More
Posted by admin on Oct 31, 2016 in |
The galls of Quercus infectoria Oliv. (Family: Fagaceae) are commonly known as “Manjakani” by Malaysian community. It is one of the most popular traditional medicines used by the females to help regression of prolapsed uterus. The aim of this study was to perform the proximate analysis and quantitative estimation of gallic acid in the methanol extract of locally available galls of Q. infectoria using HPTLC. The gall powder was subjected to the quantitative determination of moisture content, ash and extractive values according British Pharmacopoeia. Preliminary phytochemical studies were performed on different extracts to find out the nature of phytoconstituents they contain. Quantitative estimation of gallic acid in the methanol extract was assessed through denstiometric scanning using a TLC Scanner 3 (Camag, Switzerland) with win CATS software. The results of the preliminary phytochemical screening of various extracts revealed presence of steroids, triterpenoids, saponins, flavonoids, tannins and phenolic compounds, carbohydrates, gums and mucilages respectively in the galls. Amount of of gallic acid in the sample was found to be 0.218 ±...
Read More
Posted by admin on Oct 31, 2016 in |
Lyophilization also known as freeze drying is a process in which water is removed from a product after it was frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase. The process consists of three separate, unique, and interdependent processes; freezing, primary drying (sublimation), and secondary drying (desorption). Esomeprazole sodium for Injection 20 mg and 40 mg formulation was developed by optimized Lyophilization cycle. The objective of the research work was to compare the lyophilsation process cycle between Lab scale and scale up batches. The collapse temperature (Tc) for the product was identified using Freeze-drying microscope (FDM). During manufacturing the samples were exposed to above said collapse temperature to study the impact on product quality. Lab scale manufacturing was executed in Tofflon Lyophilizer 0.5 and scale-up batches were executed in Tofflon Lyophilizer 13. The Lyophilisation cycle and analytical results for both the batches were...
Read More
Posted by admin on Oct 31, 2016 in |
For estimation of carbon stocks in tropical forest types belonging to southern part of Madhya Pradesh, 30 adopted representative sites comprising eight districts viz, Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria were selected for study and studies were carried out during 2009 to 2011. The study covered three types of vegetation i.e. teak mixed forest, sal mixed forest and mixed forest. In the study modern tools like Remote Sensing (RS) and GIS were used for quick and reliable assessment of above ground biomass (AGI) and vegetation carbon pools in the region. Nested two stage sampling design was adopted to select sample plots in all forest and density classes. One super plot of 250 m x 250 m in size equivalent to MODIS pixel size was laid out in each super plot. The total sample size consisted o 30 super plots and 120 sample plots within super plots. The tree density and basal area in study sites was ranged between 105 (UMA-8) to 1508 (DIN-7) stems/ha and 22.2...
Read More
Posted by admin on Oct 31, 2016 in |
Caralluma attenuata is a perennial small, leafless succulent plant which grows in tropical and subtropical areas. It belongs to the family Apocyanaceae. The folkal information reveals that the tribes generally chew the whole plant to treat peptic ulcer, diabetes, in weight reduction to suppress hunger and also to produce endurance. It has been reported for the presence of steroids, flavanoids, saponins, triterpenes and pregnane glycosides etc., several biological activities like anti-diabetic and anti ulcerogenic were reported. In the present study an attempt is made to evaluate Anti tubercular and Anthelminthic activities for aqueous methanolic (50:50) extract after carrying out the phytochemical investigations. Anti tubercular activity was evaluated by Micro plate Alamar blue assay method against streptomycin, ciprofloxacin and pyrazinamide as standard drugs. Anthelminthic activity was evaluated on Perithima posthuma using Piperazine citrate as standard drug. The results obtained for biological activities were shown to posses considerable Anti tubercular activity at 50 µg/ml and Anthelminthic activity at...
Read More
