Posted by admin on Nov 30, 2023 in |
Multiple anatomical and physiological obstacles have always made ocular drug administration difficult. Different novel drug delivery systems, including nanogels, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ thermosensitive gels, have been developed to get around the barriers to improve ocular Bioavailability. For the encapsulation of visitor molecules, nanogel has become a flexible drug delivery technology in this aspect. Numerous techniques for the creation of nanogels have been developed over time, such as Concomitant polymerization and crosslinking, Separate polymerization and crosslinking, Micro templating/crosslinking, etc. In this work, Ofloxacin-loaded Nanostructured Lipid Carrier has been prepared with the help of Design expert software (Version 7.1.5) taking amount of liquid lipid, and homogenization speed as independent variables and particle size, spreadability coefficient, % entrapment efficiency as responses. Dynamic Light Scattering (DLS) was used for studying the particle size. The results confirmed the size of the NLC within the nano range (78.79- 648.4 nm). From the experiment, optimized product was found to be 78.79 nm with 66.2% drug entrapment efficiency and...
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Posted by admin on Nov 30, 2023 in |
The plant Pinda concanensis belongs to family apiaceae. It was native to the Western Ghats of India, but it is now becoming rare as a result of widespread usage of the seeds for their therapeutic properties. It is an annual herb with tuberous roots, which are eaten raw by local folklore. Apiaceae is the well-known aromatic plant family having beneficial uses in home remedies, abundance of phytochemicals, used in pharmaceuticals and cosmetics. The plant Pinda concanensis showed presence of phenolic, flavonoid, alkaloid, terpenoid and saponin content in each plant parts with different solvents of extraction. The methanolic extract of Pinda concanensis of different parts showed highest phytocompounds which are significant P<0.005.The total phenolic content was highest in dry methanolic stem while total flavonoid content in fresh stem. But total alkaloid, total terpenoid and total saponin was more in methanolic extract of dry root. This is the first report on GCMS analysis of whole plant extract of Pinda concanensis, in which twenty-two different compounds are found. The major bioactive compounds...
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Posted by admin on Nov 30, 2023 in |
Decubitus ulcers continue to be a common health problem, particularly among the physically limited or bedridden. Decubitus ulcers may develop into chronic conditions for no apparent reason, persist for prolonged periods, or even last the patient’s entire life. Modern medicine mainly serves in managing ulcer wounds through superficial wound cleaning and dressing. But it takes time for healing of decubitus ulcer and sometimes it’s painful and requires antibiotics and anti-inflammatory medicines if the bedsore gets infected. On the other hand, homoeopathy can best treat decubitus ulcer as it’s easy to consume and does not require multiple medications at a time. Also, a single simple homoeopathic medicine is sufficient to treat decubitus ulcer effectively and safely by relieving pain and curing blister and pus in ulcer. Case summary: A necrotizing pancreatitis patient admitted in hospital ICU for two months. There was a history of necrotizing pancreatitis due to which the patient was in critical condition & he was in ICU for the last 2 months. Due to the immobilization in...
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Posted by admin on Nov 30, 2023 in |
Chronic kidney disease (CKD) is urgent problem, because its social and economic problem of society and medicine among the population in the world.About 850 million of the world’s population suffer from various kidney diseases. Patients at the stage of CKD 5th stages may experience changes such as cardiovascular complications, uremic intoxication, severe anemia, phosphorus-calcium and other micronutrient metabolism disorders, protein-energy deficiency, and hypervolemia. As you know, menopause is an age-related physiological state of the body, the period of transition from the reproductive period to menopause, and the age of its onset is on average 50-54 years. During this period, the woman’s body is affected by the natural mechanisms of aging and hormonally determined factors of menopause, which is accompanied by an involutional restructuring of the higher parts of the central nervous system, leading to a violation of the cyclisty and intensity of secretion of gonad tropic hormones by the pituitary gland, resulting in insufficient function of the...
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Posted by admin on Nov 30, 2023 in |
This study mainly focusses on survey, conservation and awareness of ethno-medicinal plants in the Thar desert area of Barmer. Calligonum polygonoides Linn was collected from Thar Desert region of Malana village of Barmer district, locally known as “PHOG” and “PHOGRA” and belongs to Polygonaceae family. The rareness of the plant showed need for its micropropagation. Survey was conducted in specific region of Thar Desert of Barmer District. Ethnomedicinal values of maximum plants were seen and Calligonum was selected for mass multiplication. In-vitro culture was done in Calligonum polygonoides with different hormonal concentration in MS media with BAP (6-Benzylaminopurine) as cytokinin and IAA (Indole-3-acetic acid), IBA (Indole-3-butyric acid) 2,4-D (2,4-Dichlorophenoxyacetic acid), NAA(1-naphthaleneacetic acid) as auxin. In results good amount of callus induced in NAA 4mgL, shooting and callus in 2mg/L NAA with 1mg/L BAP, and rooting in IAA 1.5mg/L. This plant requires conservation via ex-situ or in-situ protocols, but in our study, in-vitro micro-propagation was performed for its conservation and their further research. The enhanced deforestation, with huge demand for...
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