Posted by admin on Mar 31, 2024 in |
Introduction: Clomiphene citrate (CC) is the primary drug of choice for ovulation induction in PCOS but resistance to ovarian stimulation is frequent observation with CC. Letrozole (Let), an Aromatase Inhibitor (AI) induces folliculogenesis by releasing hypothalamo-pituitary axis from tonic inhibitory effect of estrogen. Aim: To compare the rate of folliculogenesis, number of follicle count, ovulation rate, conception rate and pregnancy outcome. Materials & Methods: This prospective comparative study was conducted in RGKMCH & NKIIC, Kolkata from July 2018 to June 2019. In this study 200 anovulatory PCO matched women of 20-40 years were divided into two groups, Group A-100 patients receiving CC 100 mg daily and Group B-100 patients receiving Letrozole 5 mg daily from Day 2 for 5 days. Follicular study started from D9 of cycle and ovulation triggering by using Injection hCG was done as per standard protocol. Patients were evaluated in respect of terminal endocrinological profile, number of follicles, ovulation rate, pregnancy rate & outcome. Results: In Gr A & Gr B, mean no of follicles...
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Posted by admin on Mar 31, 2024 in |
The present study was carried out with an objective of formulation and evaluation of effervescent floating tablets of Tizanidine hydrochloride using combination of polymers. The floating tablets were prepared using HPMC and Tara gum as a combination of polymers. The tablet was prepared by direct compression method. The effect of polymer concentration was evaluated for gastroretention and sustained release action. Effervescence was produced by using sodium bicarbonate and citric acid which helps in reduction in floating lag time. The effect of polymer concentration on drug release and gastroretension has also been investigated. The results of in-vitro dissolution study shows that the drug formulation containing HPMC K15 M and Tara gum gives sustained action till 15 hr. Tara gum act as a sustained release polymer it sustains the dissolution of formulation by modifying the rheology of matrix. it is inert and non-toxic material. The formulation shows zero order kinetics. The matrix of formulation shows non-fickian diffusion. The present study shows that formulation gives sustained release action with muscle relaxant property...
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Posted by admin on Mar 31, 2024 in |
The study focuses on creating and evaluating a specialized bilayer tablet for treating hypertension. It begins with in-depth preformulation analyses of key components like Atenolol, Hydrochlorothiazide, and various excipients. Special emphasis is placed on optimizing the powder blend’s flow properties to facilitate tablet compression. A series of tests on resulting tablets (F1 to F8) assess weight variation, thickness, hardness, friability, disintegration time, and drug content, ensuring they meet required specifications with uniform weight and hardness. Dissolution profiles of all formulations are examined, with Formulation 8 (F8) identified as the most suitable for consistent drug release across both layers. The study investigates drug release mechanisms, finding that both layers adhere to the diffusion-controlled release model, particularly the Higuchi model. Stability tests conducted under elevated temperature and humidity (40°C/75% RH) over three months reveal minimal changes in physical attributes, drug content, and drug release profiles, confirming the tablet’s stability. In conclusion, the study successfully develops an optimized Immediate Release Bilayer Tablet containing Atenolol and Hydrochlorothiazide. This tablet offers controlled and uniform...
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Posted by admin on Mar 31, 2024 in |
Moringa oleifera leaves, have a high antioxidant content, which is beneficial for overcoming free radicals in the body. The leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate were used as effervescent agents because they both provide acceptable texture and mouth feel. This study aimed to develop an effervescent granules formulation of Moringa oleifera leaf extract and to optimize the molar ratio of citricacid and sodium bicarbonate as the effervescent agent. Three formulations using different ratios of citric acid and sodium bicarbonate were selected, namely F1, F2 and F3. These formulations were developed using the wet granulation method. The results showed by effervescent granules of the three formulations exhibited good flow ability and good particle size distribution. The organoleptic and sensory evaluation results showed formulation F3 was the most acceptable in terms of colour, taste,...
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Posted by admin on Mar 31, 2024 in |
Introduction: The analgesia effect of anesthetic drugs namely Ropivacaine, can further be enhanced with adjuvants. For postoperative pain management in infra-umbilical surgeries, Ropivacaine with an adjuvant can be used through a Transversus Abdominis Plane (TAP) block, which is a simple and clinical anatomical landmark procedure, suitable in remote areas without advanced modern technical tools. Aims: Fentanyl and Dexmedetomidine (Dexmed) were used as adjuvant to Ropivacaine, injected in TAP, postoperatively, and were compared in terms of pain relief. Material & Methods: In this randomized comparative study, undertaken from January 2021 to August 2022, 60 patients were randomly divided into two groups of 30 each, Group A- Injection Fentanyl (25 mcg) + Ropivacaine (0.375%) in 20ml dilution and Group B- Injection Dexmed (25 mcg) + Ropivacaine (0.375%) in 20 ml dilution were injected in TAP block on either side. The outcome was studied at 3, 6, 9, 12, and 24 hours, postoperatively. Results: The mean duration of analgesia in patient’s of group B was higher and statistically significant (“p-value”<0.001) than group-A....
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