Posted by admin on Sep 30, 2016 in |
Affordability to healthcare is one of the major factors that have impact on the health care access in the Indian subcontinent. It is the main responsibility of the pharmacist in ensuring that patients get the right drug in the right quantity at the right time. Thus, such prescription pattern monitoring studies can promote appropriate use and reduction of abuse or misuse of monitored drug. The aim of such studies is to facilitate the rational use of drugs in the population. Irrational use of medicines leads to increased incidence of treatment failure, antimicrobial resistance and economic burden on the patient and the community as a whole. This is a descriptive observational prospective study in monitoring the drug prescription pattern in an ENT outpatient department. The objective of this study is to evaluate the patterns of drug prescribing practised. The study conducted observed that the drug prescription pattern was not as per the WHO guidelines and its indicators. ENT disorders led to school absenteeism as most of them where school going...
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Posted by admin on Sep 30, 2016 in |
The present study aimed to compare the effect of Omega3 fatty acids (OFA) and bone marrow mesenchymal stem cells (BMSC’s) on stress induced neuronal degeneration in CA1 hippocampus region of rats. For isolation and culture of BMSCs, a three week old Wistar rat was sacrificed, femora and tibiae were collected then mesenchymal cells cultured. The 6th passage cells are analyzed by flow cytometry for the expression of CD44, CD90 for positivity and CD45 for negative expression. In this experiment, thirty six rats aged 8 weeks old were divided into six Groups (n=6). Group I was control, Group II was given forced cold water swim stress, Group III: cold stress followed by saline Group IV and V, cold stress followed by oral gavages of omega-3 fatty acids 60mg/Kg for 2 weeks (short-term model) and 4 weeks (long term model) respectively and Group VI was cold stress followed by intravenous injection of 1 X 106 BMSCs. Behavioural function test performed using Y-maze. After treatment, rats were sacrificed for Cortisol assay and...
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Posted by admin on Sep 30, 2016 in |
A novel reverse phase liquid chromatographic method has been developed for the simultaneous estimation of Atorvastatin Calcium, Ezetimibe and Fenofibrate in bulk and Pharmaceutical formulations by using reverse phase Agilent 100-5 C18 column [250mm x 4.6mm]. The mobile phase (Methanol: water) in the ratio of 70:30% v/v was pumped at a flow rate of 1ml/min and the column effluents were monitored at 250nm using Variable Wavelength UV detector. Linearity was obtained in the concentration range of 20-100 µg/ml for Atorvastatin and Ezetimibe and 50-250µg/ml for Fenofibrate. The established method was statistically validated according to the ICH Q2B guidelines and the percentage relative standard deviation for precision, robustness and ruggedness was found to be less than 2% indicating high degree of precision and robustness. The percentage recovery for the accuracy was found to be 100.52%, 100.45% and 101.31% for Atorvastatin, Ezetimibe and Fenofibrate respectively which were within the specified limits of recovery. Assay for the marketed formulation proved that 99.86% of Atorvastatin, 99.61% of Ezetimibe and 99.83% of Fenofibrate. Hence...
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Posted by admin on Sep 30, 2016 in |
The main aim of the present study is to formulate low cost natural mosquito paper coil and to evaluate the mosquitocidal activity of Annona squamosa leaf extracts. Annona squamosa Linn. is the plant belonging to the family of Annonaceae commonly known as custard apple. Several bioactive compounds have been isolated from the Annona squamosa leaf extracts reported to possess anti-diabetic activity, Mosquitocidal activity, antioxidant and anti-bacterial activities. Mosquito species are well known vectors for the transmission of vector borne diseases affecting human beings particularly malaria, dengue, yellow fever, Chikungunya fever and filariasis. In recent years development of new synthetic products and their introduction into international usage has become a very costly affair and shows side effects. Hence, a lot of time, money and resources are channelled towards the synthetic formulation. Different extracts of Annona squamosa were prepared and they are formulated as a paper coil and evaluated by using commercially obtained paper coil as a standard for its mosquitocidal...
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Posted by admin on Sep 30, 2016 in |
The objective of this study was to compare efficacy of 1% Alendronate gel and Tetracycline fibers as an adjunct to scaling and root planning (SRP). A total of 30 patients with diagnosis of chronic periodontitis (60 localized periodontitis sites) in an age group of 20-55 years were selected. None of these patients had received any non-surgical or surgical periodontal therapy and had periodontal pockets measuring 4–7 mm clinically. Two sites in any quadrants after randomization were selected in each patient. Navy Plaque index (Grossaman and Fedi) and Gingival bleeding index (GI) (Loe and Sillness), Clinical probing depth (PD) and Clinical attachment level (CAL) were measured at baseline 1,3 and 6 months. Random allocation of test site (treated with 1% Alendronate Gel) and control site (treated with Tetracycline fibers). The results revealed that there was significant improvement in all clinical parameters from baseline to 6 months and test group presented with better results than control group however the difference was not statistically...
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