Posted by admin on Jun 30, 2016 in |
Purpose: Diabetes mellitus is a significant burden to the present society, associated with various co-morbid conditions like hypertension, cardiovascular diseases, etc. A number of drugs are available to handle these health problems successfully. However, therapeutic success of such diseases is limited due to adverse effects of drugs or medicines. The aim of the present study was to evaluate the cases of adverse events due to these medications. Methods: An observational study on patients attending the Out Patient Department (OPD) of R.G. Kar Medical College, Kolkata, West Bengal, India, for a period of 8 months (September 2014- April 2015). Adverse drug events due to the use of anti-diabetic and cardiovascular drugs were collected and evaluated. Result: Present study revealed that, out of the total 48 adverse event reports collected in patients using anti-diabetic and cardiovascular drugs, 66.7% may be due to anti-diabetic drugs and 31.25% may be due to cardiovascular drugs. The prevalence of adverse effects due to antidiabetics was more in female (62.5%) as compared to male (37.5%). 40.63%...
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Posted by admin on Jun 30, 2016 in |
The purpose of the study is to update and review the latest developments related to modelling and economic evaluation of osteoporosis and further to present a reference model for the assessment of the cost of the prevention and treatment of osteoporosis. To find out the most cost-effective drug combination between the two combinations (Alendronate + Vitamin D supplements & Strontium ranelate +Calcium supplements) in osteoporotic & severe osteoporotic patients and health related quality of life of osteoporotic patients. A prospective observational comparative study (Cost-effectiveness Analysis) was carried out in 60 patients in which 30 each in severe and very severe Osteoporotic groups, who are prescribed with any one of the following combinations (Alendronate+Vitamin D supplements and Strontium ranelate+Calcium supplements) were selected. We have used 3 different parameters such as bone mineral density test (initial and final values), health related quality of life and X-Ray. Comparison of costs and effects were done. The mean of the calcium values of group 1 (Alendronate + Vitamin D supplements) during their initial visit...
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Posted by admin on Jun 30, 2016 in |
Urolithiasis is a relevant clinical problem in every day practice with a subsequent burden for the health system. Animal models of disease most closely replicate the sum of physiological conditions present in humans. Rats and mice are however, the two most commonly used experimental animals in medical research including stone disease. The oxalate metabolism in the rat is nearly identical to that in humans in many aspects. The experimental calcium oxalate Urolithiasis in the rat is similar to calcium oxalate stone disease in man. There are many methods of inducing calculi in rats. Among them Chemical method of inducing hyperoxaluria with Ethylene glycol and foreign body implantation especially zinc discs in urinary bladder of rats are the commonly used experiments. This paper will describe in detail about the Zinc disc implantation method to induce calculi in Wistar rats based on a pilot study. Focus is given to the specifications of zinc disc size, duration of calculi formation and X- ray radiography so that it will be very useful for...
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Posted by admin on Jun 30, 2016 in |
Background: Hypertension is one of the global risks for mortality and is seen with drastic rise in developing nations with rise in age. Methods: This cross sectional study was conducted in Ottapalam town, Palakkad district, Kerala, India. Based on inclusion criteria (non-pregnant, age group between 35-75 years) 142 subjects were studied. Patient data (demographics, lifestyle factors, medical reports)was collected with the help of a suitable questionnaire. Results: The results during the study period of four months on 142 subjects for hypertension and pre-hypertension revealed that, more than half (69%) of the study group were found to be hypertensives. Of the 98 reported cases, 42(29.57% of 142) were “known” cases of hypertension and 22 (15.49% of 142) were newly diagnosed cases. This included cases which were had ISH, IDH and cases having both diabetes and hypertension. A positive association was observed between hypertension and age, BMI, alcohol and, tobacco uses other than smoking. 25 patients were found to be pre-hypertensive, among which 56% (14 cases) were males and 44% (11...
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Posted by admin on Jun 30, 2016 in |
Asenapine in Tablet dosage form is used as antipsychotic agent. Literature revealed that there is no single method for the simultaneous estimation of this drug in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive UV spectrophotometric and RP-HPLC methods. The simultaneous estimation of UV method is based on the principle of additivity of absorbance, for the determination of Asenapine in tablet formulation. The absorption maximum of the drug was found to be 270.0 nm in methanol. For RP-HPLC mobile phase is a mixture of acetonitrile and 0.1 M phosphate buffer (pH = 3.2) in the ratio of 65:35 v/v and detection wavelength is 270 nm. The accuracy and reproducibility of the proposed method was statistically validated by recovery...
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