Posted by admin on Jun 30, 2016 in |
Background: Hypertension is one of the global risks for mortality and is seen with drastic rise in developing nations with rise in age. Methods: This cross sectional study was conducted in Ottapalam town, Palakkad district, Kerala, India. Based on inclusion criteria (non-pregnant, age group between 35-75 years) 142 subjects were studied. Patient data (demographics, lifestyle factors, medical reports)was collected with the help of a suitable questionnaire. Results: The results during the study period of four months on 142 subjects for hypertension and pre-hypertension revealed that, more than half (69%) of the study group were found to be hypertensives. Of the 98 reported cases, 42(29.57% of 142) were “known” cases of hypertension and 22 (15.49% of 142) were newly diagnosed cases. This included cases which were had ISH, IDH and cases having both diabetes and hypertension. A positive association was observed between hypertension and age, BMI, alcohol and, tobacco uses other than smoking. 25 patients were found to be pre-hypertensive, among which 56% (14 cases) were males and 44% (11...
Read More
Posted by admin on Jun 30, 2016 in |
Asenapine in Tablet dosage form is used as antipsychotic agent. Literature revealed that there is no single method for the simultaneous estimation of this drug in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive UV spectrophotometric and RP-HPLC methods. The simultaneous estimation of UV method is based on the principle of additivity of absorbance, for the determination of Asenapine in tablet formulation. The absorption maximum of the drug was found to be 270.0 nm in methanol. For RP-HPLC mobile phase is a mixture of acetonitrile and 0.1 M phosphate buffer (pH = 3.2) in the ratio of 65:35 v/v and detection wavelength is 270 nm. The accuracy and reproducibility of the proposed method was statistically validated by recovery...
Read More
Posted by admin on Jun 30, 2016 in |
Introduction: Psoriasis is a chronic inflammatory disease of high prevalence. In India the prevalence of psoriasis varies from 0.44 to 2.8%. The main aim of drug utilization research is to facilitate the rational drug use. Without a precise knowledge of how drugs are being prescribed and used, it is difficult to suggest measures to improve the prescribing habits. The economic burden of psoriasis is also a matter of concern to patients due to the permanent cost of treatment and the possibility of lower productivity and absenteeism in the workplace. Aims and objectives: To study drug utilization pattern of psoriasis, to estimate direct cost of therapy and to assess rationality using SIGN and NICE guidelines. Methodology: Patients attending the Dermatology outpatient department at a tertiary care teaching hospital newly diagnosed with psoriasis by the Dermatologist were enrolled in the study after obtaining written informed consent. Results: Total 120 patients received 606 drugs, number of drugs prescribed per patient being 5.05 ± 1.52 (Mean ± SD). Most frequently prescribed drug was...
Read More
Posted by admin on Jun 30, 2016 in |
The aim of the study was to determine the anticonvulsant activity of methanolic extract of Lawsonia inermis leaves in albino rats. The anticonvulsant activity of methanolic extract of leaves of Lawsonia inermis (200 mg/kg and 400 mg/kg) was assessed in rats using maximum electroshock seizure (MES) test and pentylenetetrazole (PTZ) induced seizure test. The methanolic extract of Lawsonia inermis leaves significantly (p<0.01) reduced the hind limb tonic extension in the MES test in a dose dependent manner. In the PTZ model also, the extract signicantly (p<0.01) reduced the duration of clonic convulsions as well as delay the onset of seizures in a dose dependent manner. The study demonstrates that Lawsonia inermis has significant anticonvulsant activity possibly through a GABA-ergic...
Read More
Posted by admin on Jun 30, 2016 in |
Purpose: Neonatal sepsis, a major killer among neonate, necessitates urgent implementation of empirical therapy and later specific antimicrobial therapy against causative microorganism. Empirical therapy relies upon data obtained from previous studies. We conducted this study to evaluate the blood culture, sensitivity and resistance pattern of various antimicrobial agents in neonatal sepsis at Neonatal Intensive Care Unit at a tertiary care hospital in western part of India, which will show us the changing pattern of etiological organism and antimicrobials needed to curb them. Methods: We conducted a prospective cross sectional study over a period of six month duration in Neonatal Intensive Care Unit at tertiary care hospital. We collected and analyzed the blood culture reports and sensitivity pattern of antimicrobials used. Results: We enrolled 163 patients of neonatal sepsis. Paediatricians sent 163 blood samples for culture of which 62 % culture were positive. Out of 101 positive cultures 70 % were Gram negative organisms. Most frequently encountered organisms were Klebsiella Pneumonia followed by Acinobacter species while least common was Coagulase...
Read More
