Posted by admin on Apr 30, 2016 in |
This study posed a challenge for the risk management to research and development projects in a highly regulated and volatile pharmaceutical industry, in which projects are extremely long, complex, costly and prone to failure. Project management in new product development, must be efficient and effective. This emphasizes the importance of risk management. Quality by design (QbD) refers to an advanced approach toward drug development. QbD is a vital part of the modern approach to pharmaceutical quality. There is much confusion among pharmaceutical scientists in generic drug industry about the appropriate element and terminology of QbD. The purpose of this research was to discuss the pharmaceutical QbD for formulation development with a case study of Orally Disintegrating Tablet (ODT) of Donepezil Hydrochloride (DPH). The study describes elements of the QbD for DPH ODT, include: Defining quality target product profile, identifying critical quality attributes, establishing design space, control strategy. ODT of DPH was prepared by direct compression method using Crospovidone, MCC and level of polymer was optimized, factorial design was used...
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Posted by admin on Apr 30, 2016 in |
Azima tetracantha Lam. (Salvadoraceae) is a traditional medicinal plant primarily used for mother care treatments after delivery. Based on literature survey, it was noticed that the evaluation of the biopotential of A. tetracantha, and its phytoconstituents are scarcely reported from plant materials growing in the state of Kerala, India. An attempt was made to reveal the phytochemical profile of the plant using various chromatographic as well as spectroscopic techniques. A triterpenoid of friedelane derivative, was isolated from the leaves of A. tetracantha by employing chromatographic techniques like Column chromatography and thin layer chromatography (TLC), along with preparative TLC. The isolated compound was observed to be white coloured powder consisting of needle shaped crystals. The melting point of the isolated compound was found to be 261- 263 ºC (uncorrected). The crystals were soluble in hexane, acetone, ethyl acetate and methanol. It was insoluble in water. Further spectroscopic characterization using ultra- violet spectroscopy (UV-Vis), infra red spectroscopy (FTIR), liquid chromatography mass spectrometry (LCMS) and 1H- NMR. of the compound revealed it...
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Posted by admin on Apr 30, 2016 in |
Objectives: To compare efficacy and safety of topical plus reduced dose of diclofenac to oral diclofenac in therapeutic dose. Method: The study was prospective, comparative and randomized, which included 50 patients suffering from knee osteoarthritis. Patients were randomized to receive either – oral diclofenac alone (50 mg thrice daily) (therapy1) or decreased dose of oral diclofenac and topical diclofenac (75 mg SR once daily + 10 mg Nanogel thrice daily) (therapy 2). The patients had been followed up for 7 days. Visual Analogue Scale and Lequesne Index has been used to evaluate the efficacy. Adverse drug reaction form, WHO and Naranjo Causality Assessment Scale were used to evaluate the safety of the patients. Data were analyzed by independent student t- test. Results: Out of 50 patients 17 were male and 33 were female. Osteoarthritis is more prevalent in 40-60 years of age, female patients and higher body weight and Body Mass Index (BMI). Therapy 2 was found statistically superior to therapy 1 on efficacy parameters (VAS Scale and Lequesne...
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Posted by admin on Apr 30, 2016 in |
Emergence of resistant bacterial and fungal strains towards existing antimicrobial agents is one of the major motives for research and development of new molecules to defend them. Oxadiazole is a major compound of heterocyclic nucleus for the development of new drugs. Oxadiazole ring system could be incorporated into many more ring systems which itself have their own activity and could lead to potent and highly active compounds. In silico is an expression used to mean “performed on computer or via computer Simulation”. Docking is a method used to identify the fit between a receptor and a potential ligand. In this research work In silico design of 2,5-disubstituted 1,3,4-oxadiazole derivatives were carried out by Schrodinger software for antimicrobial activity. The antibacterial and antifungal proteins were selected from Protein Data Bank and docked with hundred derivatives of 2,5-disubstituted 1,3,4-oxadiazole by using glide XP. Then five derivatives with highest glide Score were selected and synthesized. Synthesis was a microwave cyclisation reaction between hydrazide and various aromatic acids. The newly synthesized derivatives were...
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Posted by admin on Apr 30, 2016 in |
Medicinal plants therapeutic agents are a big source of information for a wide variety of chemical constituents which could be developed as new drugs. The present study focused on anticancer, antitumor anticarcinogenic and cancer preventive activities of bioactive compounds found in plants belonging to Fabaceae family. The bioactive compounds and their scientific details were mining from publically available phytochemical databases (Dr. Duke’s phytochemistry and ethnobotanical database and USDA phytochemical database). Fabaceae family is one of the largest family which includes 18,860 plant species, of them, 12 plant species were identified to posses 106 bioactive compounds related to cancer treatment. The plant species such as Acacia nilotica, Arachis hypogaea, Cajanus cajan, Crotalaria juncea, Glycine max, Mimosa pudica, Pisum sativum, Psoralea esculenta, Tamarindus indica, Trifolium pratense, Trigonella foenum-graecum and Vigna subterranean possess bioactive compounds leading to cancer treatment. The important and mostly studied phytochemical compounds are Beta carotene, Alpha tocopherol, Alanine, Genestein, Caffeic acid, Tannin, Alpha carotene, Ascorbic acid, Limonene, Daidzein, Rutin and...
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