Posted by admin on May 31, 2016 in |
Maytenus emarginatus Willd. Celeastraceae, popularly known as “Kankeri or kankero”, is a Thorny staff evergreen tree that is rich in various chemical constituents that determine the medicinal potential of this species. Diabetes mellitus is a disease that is affecting major population of the world. This study aimed to evaluate the antihyperglycaemic activity of the hydroalcoholic extract of the leaves of Maytenus emarginatus plant which is widely found in dry and arid regions of India mainly in Rajasthan. The hydroalcholic extract of the leaves of M. emarginata (250 and 500 mg/kg/day) were administered orally to streptozotocin-induced diabetic rats (n = 6/group) for 21 days. Changes in body weight, food and water intake, biochemical markers, fasting glucose levels and oral glucose tolerance test were evaluated. The results showed that the M. emarginatus dried extract (250 and 500 mg/kg) reduced significantly the level of blood glucose comparable to glibenclamide (10mg/kg) throughout the evaluation period and improved metabolic status of the animals and ameliorate the oral tolerance glucose test. Thus, we conclude that...
Read More
Posted by admin on May 31, 2016 in |
This cross-sectional questionnaire based study was conducted among 200 randomly selected child bearing mothers aged 16 to 40 to evaluate their awareness regarding breastfeeding and its health benefits in urban and slum area of Dhaka city from July to December 2013. The study showed that about 46% of respondents completed higher secondary education or more and about 27% were illiterate. A significant proportion of mothers (75%) were employed while 25% were housewives. More educated mothers had significantly (p<0.001) better knowledge about colostrum milk (91.5%) about the appropriate duration of breastfeeding (81.40%) and that breast milk is the only food recommended for babies up to 6 months of age (96.90%) in comparison to that of the uneducated mothers (49.30%; 25.35% and 77.46%, respectively). Educated mothers were also significantly more likely than uneducated women to know about benefits of breastfeeding with regard to post-partum weight loss (OR=0.462, 95% CI 0.298-0.715, p<0.001), prevention of unwanted pregnancy (OR=0.064, 95% CI 0.030-0.136, p<0.001) and post-partum bleeding (OR=0.147, 95% CI 0.083-0.257, p<0.001). Awareness of recommended...
Read More
Posted by admin on May 31, 2016 in |
Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare efficacy and safety of Diclofenac (DIC) + Proton pump inhibitor(PPI) and Diclofenac+H2 blocker in patients with knee osteoarthritis methodology: We conducted prospective randomised control open label study on 40 patients at Orthopedic OPD of tertiary care hospital. Patients were given either DIC(100mg SR OD) + PPI (Omeprazole 20mg OD) or DIC (100mg SR OD)+ H2 blocker (Famotidine 20mgOD) for two weeks. Clinical effectiveness was assessed by using Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual analogue score(VAS) as efficacy parameters. Suspected ADRs were recorded at each visit. Observation: In the present study, the prevalence of osteoarthritis was more common in the age group 50-59 years (48%) with female...
Read More
Posted by admin on May 31, 2016 in |
This research work aimed at developing and optimizing fast dissolving tablets of Promethazine Thecolate by direct compression technique. In the investigation, a 32 full factorial design was used to investigate the joint influence of two formulation variables (amount of superdisintegrants): amount of sodium starch glycolate and crospovidone. The tablets were evaluated for its percent friability and their disintegration time. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of sodium starch glycolate and a crospovidone. A contour plot was also presented to graphically represent the effect of the independent variables on the disintegration time 30 s and percent friability 0.5 %. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. The optimized tablet should be prepared with an optimum amount of Sodium starch Glycolate (2.75 mg), and Crospovidone (2.72 mg) which disintegrated in the 30 seconds, with friability of 0.5% and of drug release within 5 min. The...
Read More
Posted by admin on May 31, 2016 in |
The objective of this research was to develop and validate a simple, sensitive and specific Liquid Chromatography – Tandem Mass Spectrometry (LC–MS/MS) quantification of Varenicline in human plasma using Varenicline -D4 as Internal Standard (IS). The analyte was separated on a Zorbax SB-C18, 4.6 x 75 mm, 3.5 μm, 80 Å column with an isocratic mobile phase of 5mM ammonium formate: acetonitrile (10:90 v/v) at a flow rate of 0.8 mL/min. The protonated ions were formed by a turbo ionspray in a positive mode was used to detect analyte and internal standard (IS). The analytes were monitored by electrospray ionization in positive ion multiple reaction monitoring (MRM) mode was used to detect the Varenicline at m/z 212.1/169.0. This method is validated over a linear concentration range of 50.0–10000.0 pg/mL with a correlation coefficient (r) of ≥ 0.9997. Both drug and internal standards were stable in plasma samples. This method demonstrated intra and inter-day precision within 1.2–4.5 and 3.5–7.4 and accuracy within 91.70-105.5% and...
Read More
