Posted by admin on Jun 30, 2024 in |
Sagadevi nei is a Siddha polyherbal formulation indicated for Neerkattu and Neersurukku. The main ingredient of the formulation is Vernonia cinerea, belonging to the family Fabaceae, which has been proven scientifically to exhibit renal tubular regrowth. Based on Literature, each ingredient of the mixture has nephroprotective, diuretic, antioxidant, and anti-inflammatory properties. Cisplatin is a metallic compound antineoplastic drug with a known side effect of renal damage. The present study aims to elucidate the attenuative effect of Sagadevi Nei against Nephrotoxicity. MTT assay is a sensitive and reliable indicator of cellular metabolic activity. This study is done in-vitro by MTT assay in Human Embryonic Kidney (HEK) 293 cell lines. The toxicity was induced by cisplatin and the amount of cell damage was calculated. The Nephroprotective activity assessed by MTT Assay against cisplatin-treated HEK293 Cell lines co-treated with Sagadevi Nei showed an increase in the percentage of cell viability from 49.82% to 67.87% in a dose-dependent...
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Posted by admin on Jun 30, 2024 in |
The present study examined the potential of horsegram yush/ broth on preventing growth of calcium hydrogen phosphate dihydrate (Brushite) crystals in vitro. Crystal length was measured daily over a period of 11 days Two types of yush were tested (a) akruth yush made with only salt or (b) kruth yush with Trikatu consisting of equal proportions of long pepper (Piper longum), black pepper (Piper nigrum), and dry ginger (Zingiber officinale). These yush were tested also with addition of different concentrations of citric acid or lemon juice. The yush were prepared as prescribed in Ayurvedic texts. Kruth yush significantly inhibited crystal growth and was more effective than akruth yush. Addition of citric acid to the kruth yush, reduced crystal size from Day 2 and continued until Day 11. Percent reduction was more with higher citric acid concentration (302% with 0.001 M, 35.5% with 0.0055 M and 50.2% with 0.01M citric acid). However, citric acid alone with horsegram yush did not reduce crystal size significantly. Lemon juice was effective in reducing...
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Posted by admin on Jun 30, 2024 in |
Aim: Comparison of safety and efficacy in subtenon anesthesia versus peribulbar anesthesia in manual small incision cataract surgery by randomized control trial. Setting and design: A prospective observational study was conducted among 150 patients undergoing MSICS at a tertiary care hospital and was grouped into two groups peribulbar anesthesia and subtenon anesthesia. Material and Method: After randomization, 150 patients were assessed for various factors including pain at administration of anesthesia and pain during surgery. Result: A total of 150 patients were studied. The result shows no significant difference in pain during surgery and time of administration. Occurrences is chemosis and sub-conjunctival hemorrhage are more common in subtenon than in peribulbar anesthesia. Conclusion: Subtenon’s anesthesia is safe and effective as peribulbar anesthesia and is more comfortable for patients during...
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Posted by admin on Jun 30, 2024 in |
Phytic acid and amylose in rice food play an essential role in human health. The best-practiced approach is necessary for nutritional quality improvement of rice grain. The mutational breeding approach and chemical treatment are powerful methods to enhance rice quality by managing the concentration of phytic acid and amylose contents. The analysis of glycemic index and amylose contents is also significant to reduce the risk of diseases. The present research investigates nutrient quality such as phytic acid and amylose content in the developed rice mutant (PBEF20). The developed mutant shows a 50% reduction in phytic acid with a 37.73% increment in amylose contents compared to the control i.e., untreated sample. The Inositol phosphate kinase (IPK-1) and ABC-2 type transporter domain-containing protein differentially downregulated in the early flowering mutant. IPK-1 gene is responsible for converting inositol 5-phosphate (IP5) to inositol 6-phosphate (IP6). The ABC-2 type genes are vacuolar transporters to transport the phosphate that assists in synthesizing phytic acid. The identified genes, including beta-amylase and chloroplast precursor, regulate various functions...
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Posted by admin on Jun 30, 2024 in |
The medicinal plant Elaeocarpus serratus Linn., (Elaeocarpaceae) has been utilized in traditional medicine for various ailments. However, upon reviewing the literature, it was found that no anatomical work had been conducted on this plant. Therefore, our present study aimed to determine the macroscopic and microscopic characteristics of fresh leaf and stem of Elaeocarpus serratus. The macroscopic study is a technique of qualitative evaluation based on the study of morphological and sensory profiles. Externally, the leaves simple, alternate, spiral, clustered at twig ends, petiole 1.2- 4cm long and glabrous, lamina is elliptic with an acuminate or obtuse apex, base acute, serrate margin and glabrous and it appears red when senescent, midrib slightly raised above the surface. Inflorescences are in racemes, with white flower petals. The microscopic study is a qualitative evaluation technique used to confirm the structural details of drugs. Internally, the leaf exhibits both abaxial and adaxial epidermis, granular trichomes are unicellular, unbranched, wide and straight with pointed tip, cortex with tannin contents and calcium oxalate crystals. The petiole...
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