Posted by admin on Mar 31, 2016 in |
Kencur (Kaempferia galanga L.) is a plant of Zingiberaceae family. Some studies have shown that kencur can reduce inflammation because flavonoid kaempferol which is contained in kencur has anti-inflammatory activity. Optimized the use of the rhizome kencur, research was conducted on anti-inflammatory plaster containing kencur rhizome extract and its effectiveness for treating inflammation. The study was conducted through the stages of manufacture of plasters kencur rhizome extract and effectiveness of anti-inflammatory plaster test on acute inflammation. Based on this research, kencur rhizome extract can be manufactured as plaster. There were 5 groups of animals test using male white rats Wistar strain which is induced by carrageenan for acute inflamation test. The result showed by one-way ANOVA (analysis of variant) with a 95% confidence level, there was a significant difference between test groups and negative control group based on variation doses for inflamation test. Kencur rhizome ethanol extract can be used as anti-inflammatory plaster to reduce inflammation in...
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Posted by admin on Mar 31, 2016 in |
Cucumis sativus (Cucumbers) have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammatory, and anti-cancer benefits. Cucumbers are a valuable source of conventional antioxidant nutrients including vitamin C, beta-carotene, and manganese. Fresh flowers of Cucumis sativus were extracted and evaluated for antioxidant activities by 2,2-Diphenyl 1-picryl hydrazyl solution (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sul- phonic acid (ABTS) assay and anti-inflammatory activites by human blood cell (HRBC) membrane stabilization method and Inhibition of albumin denaturation method. The results obtained showed that the compound isolated from ethyl acetate fractions of Cucumis sativus flowers can be considered as good sources of anti-oxidants, anti-inflammatory and can be incorporated into the drug formulations. This study justifies the anti-oxidants, anti-inflammatory activity of the compound isolated from ethyl acetate fractions of Cucumis sativus flowers....
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Posted by admin on Mar 31, 2016 in |
Malaria remains one of deadly diseases in Indonesia which mainly occurred in Tobelo, North Halmahera. Genetic factor is one of significant factors where the gene acting in protein and enzyme coding influences the drug pharmacokinetics. However, no studies have been carried out on the pharmacokinetics of anti-malaria of primaquine in Indonesia. The purpose of this research is to know the kinetic profile of primaquine combination in the uncomplicated falciparum malaria, the relation of drug content and parasite clearance, and its pharmacological effects. Random clinical tests were conducted with experimental method to 12 patients RSUD Tobelo, North Halmahera from September to December, 2014. Blood samples were taken sequentially starting from day 0 to day 28, and then thick blood drop, liver function, kidney function, leucocyte, erythrocyte and hemoglobin were tested, The samples were then tested to measure the kinetic concentration of by using LCMS as well as analyzing the parameters of its pharmacokinetics. The results showed that the kinetic the primaquine kinetics synergized well and it was mutually complementing where...
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Posted by admin on Mar 31, 2016 in |
A new flavone glycoside 1 m. p. 223-225ºC, m. f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Taraxacum Officinal weber along with one known compound Taxifolin. A compound 1 was characterized as 6, 4′-dimethoxy-5, 7-dihydroxy-flavone- 7 – O – a – L-rhamnopyranosyl-(1®4) – O – β – D xylopyranosyl-(1®4)-O-β-D-glucopyranoside by various chemical degradations and spectral...
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Posted by admin on Mar 31, 2016 in |
The present paper deals with the analysis of methane sulfonic acid, benzene sulfonic acid and camphor sulfonic acid counter anions in pharmaceutical ingredients (doxazosin mesylate, amlodipine besylate and clopidogrel camphor sulfonate) by suppressed conductivity anion chromatography. The diluent used for the preparation of sample solution was Milli-Q Water and injected into a standard chromatographic system connected with 250 mm length, 4.0 mm ID, 5.0 µm particle size, Metrosep A Supp1 column and suppressed conductivity detector. The developed analytical method was highly precise and accurate compared to titration methods and HPLC-UV detection methods to analyze counter ions in drug substance. Calibration curves were linear with correlation coefficient of > 0.999 for anions. The % RSD of area response of anions in standard injections was below 2.0, which demonstrates the method precision of the test procedure. The accuracy of the method was also studied and observed between 97% and 102%. The developed method was validated according to ICH guidelines for the quantitative determination of anions in API taken for the...
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