Posted by admin on Mar 1, 2016 in |
Hypothyroidism is a metabolic disorder, which results in slower rate of metabolism leading to life threatening medical conditions like diabetes and other complications. This study aims to analyze the prevalence of hypothyroidism and its co-morbidities in relation to the causes and risk factors in patients undergoing levothyroxine therapy and to know the adherence level of prescribers to the Thyroid Dysfunction and Dyslipidemia Guidelines of Indian Thyroid Society. Methods: This was a cross-sectional, observational, questionnaire-based, single visit study, which included adult patients who were on levothyroxine treatment for at least three months prior to enrolment. Demographic details, data pertaining to etiology of hypothyroidism, the dose of thyroxine used, comorbid conditions, and concomitant medications used were also documented. Compliance to Thyroid Dysfunction and Dyslipidemia Guidelines of Indian Thyroid Society was assessed and documented. Results 32% of the study population suffered from primary hypothyroidism. It was also found out that levothyroxine was given along with so many other medication classes with cardiovascular system drugs being the most prescribed medications. Regarding adherence to...
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Posted by admin on Mar 1, 2016 in |
The present study was concerned with analysis of the chemical constituents of essential oil of Citrus karna fruit peels by GC-MS technique and also its antibacterial activity against some pathogenic bacteria. The essential oil was extracted from fruit peels by steam distillation using Clevenger’s type apparatus. GC-MS analysis of essential oil showed presence of D-limonene and β-pinene as the major constituents. The antibacterial activity was detected by agar well diffusion method against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphyloceceus aureus. The zones of inhibitions obtained were recorded and analyzed against standard control of Ampicillin. The essential oil showed higher antibacterial activity of 18.0 mm against P.aeruginosa and least antibacterial activity of 13mm against B. subtilis. The MIC of the essential oil on the susceptible bacterial isolates was between 111-333μg/ml. Present study concludes that essential oil from fruit peels of Citrus karna have a broad spectrum antibacterial activity against human...
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Posted by admin on Mar 1, 2016 in |
Herbal medicines have been widely utilized as effective remedies for the prevention and treatment of multiple health conditions for centuries by almost every known culture. Leptadenia reticulata belonging to the family Asclepiadaceae is an important medicinal plant which is used for various ailments. In the present study, an attempt was made to study the wound healing activity of aqueous extract of Leptadenia reticulata (AELR) using excision and burn wound models. In each model, animals were divided into three groups (n=6). Group I served as disease control group, received gel base, group II received AELR gel 10% and group III served as standard and received povidone-iodine 10% ointment. AELR gel 10% showed a significant (P<0.01) in both excision and burn wound models, which was comparable with the standard povidone iodine 10% ointment. Wound healing activity was also confirmed by histopathological studies. The present study suggested that topical application of aqueous extract of Leptadenia reticulata gel 10% plays an important role in wound healing activity. These finding could justify the inclusion...
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Posted by admin on Mar 1, 2016 in |
Semecarpus anacardium plant derivatives has been used since antiquity, The fruit and nut extract of Semecarpus anacardium shows various activities like antiatherogenic, anti-inflammatory, antioxidant, antimicrobial, antireproductive, CNS stimulant, hypoglycemic, anticarcinogenic, antifertlity effects. The present study is an attempt to explore the antiovulatory effect of aqueous and ethanolic extracts of fruits of Semecarpus anacardium plant in female albino rats. Objective: To study the antiovulatory activity of aqueous and ethanolic extracts of Semecarpus Anacardium fruit in female albino rats. Materials and Methods: Total of 54 Wistar female albino rats were selected weighing about 150 – 200 grams with atleast three regular estrous cycles were divided into 9 groups containing 6 ratseach were administered aqueous and ethanolic extracts of Semecarpus anacardium fruit both were administered in doses of 200,400,600,800 mg/kg, b.wt for different group daily for 21 days and estrous cycle monitored for 30 days daily. Control group received vehicle (Tween 80 1%, p.o. daily) and the estrous cycle was monitored daily, doses for the study selected after acute toxicity studies. Results:...
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Posted by admin on Mar 1, 2016 in |
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability and to increase the residence time of drug by bringing the drug in the vicinity of absorption window by formulating it in mucoadhesive drug delivery system. An attempt has been made to increase the bioavailability of Norfloxacin by formulating mucoadhesive suspension in different Polymers. Increase in time, speed of homogenization decreases the particle size and increases the zeta potential. Batches formulated with soyalecithin, antinucleating agents, showed decreased particle size. The comparative studies of dissolution studies showed, 99.55% of processed suspension released in 10Min. as compared to 101.63% released in 40Min. for marketed suspension respectively. The reason for increased percent release of drug in short time (10Min.), for processed suspension is, more...
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