Posted by admin on Feb 29, 2024 in |
The Indian medicinal plant Boswellia serrata, sometimes known as frankincense in the West, has been used in traditional medicine to heal burns and wounds. The objective of this study was to investigate the capability of B. serrata (Boswegex®) to enhance wound healing by carrying out an in-vitro scratch experiment on human dermal fibroblast cells (HDF). Povidone-Iodine 5% cream was used as a positive control to determine the efficacy of Boswegex®‘s wound healing activity. The cytotoxicity, along with proliferation and migration activities, were evaluated against the human dermal fibroblast cell line HDF using the MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium] assay. Interestingly, Boswegex® was found to stimulate proliferation and migration of HDF cells at given concentrations and enhance the closure rate of the wound area within 24 hours after treatment. Boswegex® was evaluated for its cytotoxicity at different concentrations ranging from 1000 µg/ml to 0.975 µg/ml, which resulted in 7.78±0.06 µg/ml and hence the concentrations of 2µg/ml and 1µg/ml. In the scratch assay, 349.62µM and 234.8 µM migrations of cells were exhibited...
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Posted by admin on Feb 29, 2024 in |
The objective of the research was to compare the efficacy and safety of Olanzapine versus Risperidone as an add-on to Lithium carbonate in patients with bipolar affective disorder. Methods: Prospective, randomized, comparative study conducted in psychiatric Department from Nov 2018 to May 2020. 80 BPAD patients who fulfilled eligibility criteria were randomized (1:1) into two groups of 40 each receiving Olanzapine with Lithium (Group A) or Risperidone with Lithium (Group B) for 12 weeks. Efficacy was measured by reduction in Young Mania Rating Scale (YMRS) score and Hamilton Depression Rating Scale (HAM-D) score at 6th and 12th week. Safety was assessed by monitoring treatment emergent adverse effect. Data analysed using repeated measure ANOVA, Mixed ANOVA, chi-square and descriptive statistics. Results: Olanzapine and Risperidone treated BPAD patients showed significant reduction in YMRS score from baseline to 12th week (p<0.001) but there was no statistically significant interaction between time and groups (p=0.71). Significant reduction in HAM-D score from baseline to 12th week was observed in both Olanzapine and Risperidone group (p<0.001)...
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Posted by admin on Feb 29, 2024 in |
Rheumatoid arthritis is an autoimmune and inflammatory disease, in which immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. Aceclofenac is a phenyl acetic acid derivative and NSAID with anti-inflammatory, analgesic and antipyretic effects. Nanosponges were prepared by the Emulsion solvent diffusion method with varying concentrations of Ethyl cellulose and Poly vinyl alcohol. FTIR and DSC study reports confirmed the absence of incompatibilities between the drug and the excipients. Nine Nanosponge formulations were prepared (F1- F9) and evaluated for particle size, PDI, Production yield, entrapment efficiency, Zeta potential, SEM analysis, in-vitro drug release and kinetic studies. The kinetic data analysis of Nanosponges fit to Higuchi model and follows Zero order kinetics. All the Nanosponge formulations were incorporated into 1% Carbopol gel base to produce drug loaded Nanosponge gel. The drug-loaded Nanosponge gel was evaluated for physical properties, pH, Viscosity, Spreadability, Extrudability, Drug content and in-vitro drug release, in-vitro anti-inflammatory activity, ex-vivo permeation study, kinetic study and stability...
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Posted by admin on Feb 29, 2024 in |
Introduction: The Emergency Medicine Department presents distinct challenges, both diagnostic uncertainty and time constraints. Promptly administering the right drugs in this setting can be crucial for saving lives. Hence, we conducted a study to analyse the prescriptions in the patients admitted to Emergency Medicine Department. Method: This is a prospective, observational single center study conducted at the Emergency Medicine department for one year. The study was started after approval from Institutional Review Board (IRB). All patients of any gender and any co-morbidities admitted to emergency medicine department were included in the study. Results: In this study, total 305 patients included, out of which majority 79 (25.9%) patients were in the age young group 31-40 years. Gender distribution depicts 262 (85.9%) and 43 (14.09%) were males and females respectively. Two wheeler accidents 119 (39.01%) were the most common. Total 186 (64.13%) patients having GCS score 11-15. Pantoprazole was the most commonly prescribed drug, prescribed in 200 (81.96%) prescriptions. Ondansetron was in used in 90 (28.19%) patients. Cefixime is used in...
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Posted by admin on Feb 29, 2024 in |
Introduction: Oxalis corniculata (Family: Oxalidaceae) is a delicate therapeutic herb found in warm temperate tropical areas of India and Pakistan, while Portulaca oleracea (Family: Portulacaceae) thrives in sultry, equatorial regions and has origins in South America and Africa. This study aims to develop and assess a topical poly-herbal gel containing leaf extracts of Oxalis corniculata and Portulaca oleracea. Materials and Methods: The plant material was collected, and shade dried before being powdered. The powder was soaked and macerated in methanol, followed by extraction using Soxhlet method. Phytochemical tests were conducted qualitatively. Gel formulations were prepared and the appearance, homogeneity, pH, and viscosity of the formulations were determined. Antimicrobial activity was evaluated. Antioxidant potential was analyzed through the DPPH scavenging assay. Additionally, in-vitro toxicity of formulations was assessed using the MTT assay to determine their compatibility with normal cells. Results: Both plants showed presence of alkaloids, tannins, phenols, flavonoids, and steroids. The gel formulations exhibited good appearance which were tested for antimicrobial activity against S. aureus and K. pneumoniae, which...
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