Posted by admin on Dec 31, 2023 in |
In this study, the anthelmintic activity of Kalanchoe pinnata leaves extract against Indian earthworm Pheretima posthuma was evaluated and compared with the standard drug Albendazole. This activity was concentration dependent. As the concentration increases the extract produce maximal effect. Higher concentrations of ethanolic leaf extract of Kalanchoe pinnata produce a paralytic effect much earlier and time taken for death was shorter. It shows maximum efficacy at 100 mg/ml concentration than the standard drug. The results indicated that the extract had significant anthelmintic activity, as demonstrated by the time of paralysis and death of worms. These findings suggest that Kalanchoe pinnata leaves extract could be a promising natural anthelmintic agent. Further research is recommended to isolate and identify the active principles responsible for its activity, which could lead to the development of new drugs for the treatment of worm infections. This study provides valuable information on the medicinal properties of Kalanchoe pinnata and highlights the potential of natural products as an alternative to conventional drugs for managing parasitic...
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Posted by admin on Dec 31, 2023 in |
Environmental changes influence Physical and Chemical reactions such as pH, Temperature, EC and chemical properties such as Dissolved Oxygen, Organic matter, Silica provide important information on Soil and Water quality different sources of variations and their effects on activities and biodiversity of Soil and Water. In the present study, the Physico-Chemical parameters of Soil sample from Vizag near Bheemili River at location of estuarine region and Water sample from Antarvedi location at sakhinetipalli were compared to provide basic information on the Physical and Chemical characteres in this area of the study. The result shows that there is very little impact on water quality pollution and this study can be used for the quality to maintain aquatic ecosystem, resources, and Agriculture. Reconstruction of the Physico-Chemical properties of Soil and Water in these areas is needed as isolation and characterization of Photosynthetic Bacteria for future...
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Posted by admin on Dec 31, 2023 in |
The objective of this research study is to assess the quality standards of various brands of Metformin hydrochloride tablets that are locally available in Hyderabad, India, by comparing and contrasting them with the brand available in the Jan Aushadhi stores in India (MET-3). Eight brands of Metformin tablets (500 mg) were selected and compared for their physical and chemical parameters as per the official method. The physiochemical equivalence of all tablet brands was assessed through evaluation of both official and non-official standards such as size, shape, uniformity of weight, friability, hardness, disintegration, assay, and dissolution rate. In contrast to the generic drug of metformin available at Jan Aushadhi Kendra (MET-3), the other seven brands of Metformin hydrochloride tablets have all met the requirements of the official I.P. specification regarding weight variation, friability, hardness, disintegration, assay, and dissolution rate. It was concluded that the generic drug of metformin available in Jan Aushadhi Kendra (MET-3), whose price is almost 70% less than the other seven brands of Metformin hydrochloride, is officially...
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Posted by admin on Dec 31, 2023 in |
Background: In the present era of quality accreditation, considering the quality of medical education is also very important, especially in developing countries. The present study was planned to understand the current state of medical education and explore medical students’ perception of their learning environment so that problem areas can be identified both at the institutional and curriculum level. Methods: DREEM tool was circulated to all willing participants from first to final-year MBBS students. Data was collected and analyzed using recent SPSS software. Descriptive statistics were used to calculate mean, standard deviation, and minimum and maximum values. One-way analysis of variance (ANOVA) was calculated, and p< 0.05 was considered to be significant. Results: An overall score of 111.76 (55.88%) out of 200 was obtained indicating ‘more positive than negative’. The overall mean score was 2.21±0.58, which is interpreted as an ‘educational aspect that could be enhanced’. Out of five domains, students’ perception of teachers scored the maximum (57.95 %) rating while students’ social self-perception scored the least (49.35 %). The relationship between...
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Posted by admin on Dec 31, 2023 in |
Metoprolol Succinate is an effective cardio-selective beta-1 blocker, that is used to treat acute disorders such as hypertension and cardiac diseases such as angina pectoris and cardiac heart failure (CHF). Oral route is the most convenient route for introducing different kind of drugs as it is preferred as the safest, cheaper & easiest route. Newly, researchers developed fast disintegrating tablets (FDT) with improved patient compliance. The main motto of this fast-disintegrating sublingual tablet is that is placed under the tongue &disintegrates rapidly within a short span of time in the presence of saliva. First-pass metabolism can be avoided by the sublingual route &the drug directly reaches into the systemic circulation. FDTs manage to overcome from hindrances such as dysphagia in pediatric, geriatric & unconscious patients. The FDTs were formed by different conc. Of super disintegrating agents such as crospovidone by direct compression method. The compatibility study of API & other excipients was studied & determined by DSC & FTIR techniques. The formulation was evaluated by studying various parameters such...
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