Posted by admin on Jan 1, 2016 in |
The present investigation studied a novel bilayer tablet having extended release of rosuvastatin calcium (RSTCa) and immediate Release of fenofibrate (FB) in different polymers using wet granulation techniques. Granules were characterized by fourier-transformed Infrared Spectroscopy (FT-IR), differential Scanning Calorimetry (DSC), as well as by content uniformity, in-vitro dissolution studies and release kinetics. Selected granular system was subjected to bilayer tablet preparation by direct compression. Compressed tablets were evaluated for drug content, weight variation, friability, hardness, thickness, %assay and in-vitro dissolution studies. Prepared tablets were then coated and coated bilayer tablets were evaluated for the same. Functional groups of RSTCa and FB were retained in respective granules, suggesting absence of chemical interaction with any of the excipients used in the preparation of granules. Absence of specific peaks in physical mixtures revealed that FB has been completely converted to molecular form. Among the polymers used to improve drug release, MCC and HPMC K4M showed better control over drug release. Formulated bilayer tablets gave satisfactory results for various physicochemical evaluations and best...
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Posted by admin on Jan 1, 2016 in |
Objectives: To know the effects of chewing the fennel and cardamom seeds on plaque and salivary pH. Materials and Methods: 50 subjects (aged 18-60 years) attending V.S dental College and Hospital who gave consent to participate were recruited for this clinical study. Subjects were randomized in to two groups for chewing fennel and cardamom seeds. Salivary pH and plaque PH at baseline and immediately after chewing seeds for 5 minutes and after 10 min was measured using calibrated glass combination electrode and analysed by ANOVA. Results: The mean salivary PH scores at baseline, immediately and 10 minutes after chewing fennel seeds was 7.1, 7,3 and 7.5 (p value 0.001). The mean salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4 , 7.6 , 7.76 (p<0.05). The mean plaque pH scores at baseline, immediately and 10 min after chewing fennel seeds was 7.4, 7.55, 7.53 (p value 0.001). The mean plaque pH scores at baseline, immediately and at 10 min after chewing cardamom seeds...
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Posted by admin on Jan 1, 2016 in |
Microalgal like Chlorella vulgaris, being a unicellular green algae, is been widely studied for nitrogen and phosphorus removal and as potential feedstock for biodiesel production. This not only saves water from eutrophication but also becomes a good source of biodiesel. Hence, if two approaches are combined we can overcome the major challenge of both eutrophication and energy crisis. In the present study we have examined the effect of decreasing Nitrogen and phosphorus concentration in medium on growth, biomass and lipid content of C. vulgaris. Significant decrease in growth and biomass was observed with the decrease of nitrogen and phosphorus concentration in the medium from (1.5g/l to 0.0g/l) and (0.04g/l to 0.0g/l) respectively. Whereas the lipid accumulation showed reverse trend of increase when the concentration of both phosphorus and nitrogen where decreased in medium. At the same time, the effect of variation in pH and saline ranges on growth, biomass and lipid content of C.vulgaris were also evaluated. The growth, biomass and lipid content showed a significant difference due to...
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Posted by admin on Jan 1, 2016 in |
Cipadessa baccifera (Roth.) Miq. of Meliaceae family, is an ethnobotanically important plant and is widely used in folklore medicine for treating a range of maladies including diabetes, dysentery, malaria, rheumatism, piles, head ache, and psoriasis. The present study was aimed at investigating the essential oil composition from the leaves of C. baccifera. The essential oil was extracted through hydrodistillation and its chemical composition was analyzed by gas chromatography and mass spectrometry technique (GC-MS). The yield of essential oil based on the dry weight of the plant was 1.1% (v/w). Forty one different phytoconstituents accounting for 99.62% of essential oil were identified. The study showed the presence of Sesquiterpenes as the major group of compounds representing 78.14% of the total essential oil. Significant Sesquiterpenes identified were Caryophyllene (17.32%), Isoledene (9.12%), 1S, Cis-Calamenene (7.42%) and β-Sesquiphellandrene(7.32%). Sesquiterpenes are known to exhibit pharmacological activities and the present report could contribute for their further use as anticancer, immunosuppressive and anti-inflammatory...
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Posted by admin on Jan 1, 2016 in |
The administration of atropine to a large population for treatment of intoxication carries the risk of allergic or toxic reactions in a small number of patients. It has been reported rarely in the literatures .We describe a cases of atropine-induced psychotic disorder in a substance abused patient and different approaches of management. Dryness of the mouth, blurred vision, photophobia and tachycardia commonly occur with chronic administration of doses. In addition psychotic symptoms such as restlessness and excitement, hallucinations, delirium may occur due to atropine. This is a study of a 55 year old female patient who manifested with visual and auditory hallucination, fatigue, anxiety, headache visual disturbances and chest tightness after intake of atropine. To manage this adverse drug reaction the dose of atropine was progressively reduced to 1ml/hr and 0.5ml/hr and discontinued after appearance of signs of complete atropinization. Patient was given with IV morphine 2 mg/hr to manage agitation and IV haloperidol 5mg as required to managing the psychiatric effects. Physostigmine, scopolamine or glycopyrrolate was given in some cases as replacement of...
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