Posted by admin on Mar 31, 2016 in |
The aim of the present study is to evaluate the gum of Curcuma amada (mango ginger) as a tablet binder employing paracetamol as a model drug. Natural gums are economic, easily available and found useful as tablet binder. The physicochemical properties of a gum obtained from the rhizomes of Curcuma amada were characterized by Fourier transmittance infra red (FTIR) and Differential scanning colorimetry (DSC). Amada gum has a glass transition (Tg) temperature and melting peak at 94.3°C. Paracetamol tablets were prepared by wet granulation technique using amada gum as a tablet binder in the concentrations of 1%, 3%, 5%, 7% & 9% w/w and compared with standard binders. The prepared tablets were evaluated for tablet characteristics. The values of granules showed angle of repose good flow property. The hardness of the prepared tablets varies with binder concentration. The prepared tablets showed friability decrease with increases concentration and disintegration time increase with increase the binder concentration. In vitro drug release was also depending on binder concentration. Tablets with 1%and 5%...
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Posted by admin on Mar 31, 2016 in |
The combination of agarwood (Aquilaria crassna) young leave with α-tocopherol (α-TOH) showed a synergistic effect which helps to protect the food from lipid oxidation. The present study was designed to elucidate the acute toxicity of the mixture of A. crassna young leaves crude ethanolic extract (CE) and α-TOH on Balb/c mice. This acute oral toxicity study was carried out based on OECD 423 guidelines by using female Balb/c mice weighing 15-25 g. First group was served as control group which received dimethyl sulfoxide (vehicle) while second, third and fourth group were orally administered with single dose of 2000 mg/kg of CE, α-TOH and a mixture of CE and α-TOH (1:2), respectively. Throughout 14 days of observation, no behavioural changes were seen in all the treated animals. Body weight for each mouse and the relative organ weights for liver, kidney, lung, heart and spleen showed insignificant different (p>0.05) when compared to the control group. These results indicate the safety of the acute exposure of the A. crassna CE, α-TOH and...
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Posted by admin on Mar 31, 2016 in |
An efficient and sensitive RPHPLC method was developed and validated for the estimation of Sitagliptin Phosphate process impurities in drug substances which were identified and characterized by LCMS, FTIR, 1H NMR, C NMR techniques. The method was carried out on a Symmetry shield RP 18 column at 25°C using a 1 % Perchloric acid and acetonitrile in gradient mode of pump. The flow rate is 1.2 ml/min and detection was done at 210nm.The developed RP HPLC method was validated by testing specificity, precision, Forced degradation, detection limit, quantification limit, linearity ,accuracy, robustness and range. The linearity of the method was confirmed over the range of 0.113 to 3.384µg/ml for Sitagliptin Phosphate impurities with correlation coeffients greater than r=0.999.The accuracy of the method was found to be 98.5 to 101.1% and %RSD as found to be less than 2% indicating high degree of accuracy and precision for the proposed method. The effective recovery and lower RSD proves the highness of the proposed RP HPLC method for the routine determination of...
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Posted by admin on Mar 31, 2016 in |
The objective of present study was to preclude of poor dissolution of relatively water insoluble and poorly permeable drug by formulating gastroretentive floating tablet using solid dispersion (SD) of the drug. It aimed to increase the drug solubility and gastric retention of the drug for better absorption profile. Cefpodoxime proxetil is an orally absorbed third generation cephalosporin antibiotic. The oral bioavailability and biological half life is 50% and 2.09 to 2.84 hrs respectively. Two grades of Polyethylene glycol (PEG); PEG 4000 and PEG 6000 in combination were used for the formulation of solid dispersion. Formulation batch SD8 was found to be optimized according to the face centred cube design (FCCD). Solubility and the drug release from batch SD8 was maximum in 0.1N HCL, 18.93mg/ml and 94.66% respectively as compared to physical mixtures (PM) and pure drug. The physical mixture having same carrier ratio (PEG 4000+PEG 6000) that is PM8 has solubility and drug release 13.93mg/ml and 76.34% respectively. The study showed that solubility and drug release has linear relationship...
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Posted by admin on Mar 31, 2016 in |
Gentamicin causes kidney cellular damage by alterations in biological functions. This study evaluated the nephroprotective potential of the ethanolic extract and its fraction originating from Sapindus emarginatus Vahl. (Sapindaceae) bark against the Gentamicin – induced nephrotoxicity in rat. Objective: To evaluate the nephroprotective effect of ethanol extract and its organic solvent fraction of S. emarginatus Vahl. in gentamicin-induced acute renal failure in rats. Materials and Methods: Nephrotoxicity was induced in wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for ten days. The treatment was done with silymarin 50 mg/kg, ethanol extract 200 mg/kg/p.o. and its ethyl acetate fractions 100 mg/kg/p.o. bark of S. emarginatus was determined using parameters serum creatinine, urea, uric acid, blood urea nitrogen, albumin, protein, other parameters are kidney weight, body weight, urine volume and histopathology of kidney. Results: It was observed that the ethanol extract and its ethyl acetate fractions bark of S. emarginatus has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. In...
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