Posted by admin on Oct 31, 2023 in |
A known case of a cervical polyp of a 26-year-old woman presented in the Outdoor-patient Department of Dr. D. Y. Patil Homoeopathic Medical College and Research Centre with complaints of abnormal bleeding in between periods, pain after coition, and profuse white discharge. USG reports confirmed the diagnosis of the cervical polyp. After a detailed history taking of the patient and considering a complete totality of symptoms, Natrum Muriaticum 30C, a single individualized homeopathic medicine, was prescribed to the patient, and it proved effective in the treatment of cervical polyp. The patient slowly showed improvement in physical symptoms, followed by mental symptoms. Modified Naranjo Criteria were used, and regular follow-ups were taken to assess the case. This case demonstrates the usefulness of homeopathic medicines in psychosomatic diseases wherein the psychological cause is the main cause of the disease in the patient. Also, this case shows the effectiveness of Homoeopathic remedies in the treatment of cervical polyps. It can be looked at as an alternative method of treatment with further research...
Read More
Posted by admin on Oct 31, 2023 in |
Objective: Teratogens play a crucial role in the 4-5% of infants who are born with physical or functional abnormalities in this world. Teratogens are recognized for their capacity to harm fetuses or neonates. Observations: Pregnancy-related exposure to certain substances may result in birth abnormalities or malformations of the fetus, such as behavioral or emotional problems, low IQ, physical deformities, etc. Because teratogens are more likely to cause harm between 15 to 60 days during organogenesis, major abnormalities are more prevalent in early embryos than in newborns. There are many different kinds of medications, and some of those that are often used during pregnancy can have teratogenic effects during various trimesters. Pregnancy is often separated into three trimesters. According to several studies, 70% of pregnant women consume at least two or three medications, including prescription pharmaceuticals and over-the-counter medicines, throughout pregnancy or the first trimester of organogenesis. Conclusion: The current study focuses on how pregnancy and physiology during that time influences the pharmacokinetics of drugs that may reach and harm...
Read More
Posted by admin on Oct 31, 2023 in |
Guillain-Barre syndrome occurs when the body’s immune system targets a portion of the peripheral nervous system. In addition to the nerves that convey pain, temperature, and touch sensations, the condition can also impair the nerves that regulate muscular movement. This may lead to muscular weakness and/or loss of feeling in the arms and/or legs. A 12-year-old boy was taken to the hospital with chief complaints of Weakness in bilateral upper and lower limbs, trouble in swallowing, inability to hold neck, mouth frothing, fever spikes. On physical examination, the patient has experienced weakness in bilateral upper and lower limbs, bulbar weakness is present, pain experiencing in both legs, S1 and S2 sound are present, Air entry is bilaterally equal, pupils are reflected to light, tone and power of upper and lower limbs are decreased”, then treatment was initially started with immunoglobulin therapy, intravenous fluids, antibiotics, amino glycosides, glucocorticoids, anti-allergic as per physician orders. In this study, we primarily focus on professional management and summarize the clinical aspects of GBS, its...
Read More
Posted by admin on Oct 31, 2023 in |
Ziziphus nummularia is commonly found plant in dry regions of South Asia such as India, Pakistan. Z. nummularia contains numerous phytochemicals such as flavonouds, alkaloids that are responsible for numerous biological activities. In current study, elaborative pharmacognostic studies on the leaves of Z. nummularia were done for standardization purposes for future studies. The study includes morphology, microscopy, physicochemical properties, phytochemical studies and fluoroscence analysis. Besides, pesticides residue, heavy metal residue, aflatoxins and microorganism analysis were also carried out for the standardization. Further in-vitro anti-inflammatory activity of successive extracts viz. petroleum ether, chloroform, ethyl acetate, ethanol and aqueous extracts was assessed using protein denaturation, RBC membrane satbilisation and protease method at varying concentration i.e. 250, 500, 750, 1000 and 2000 µg/ml. The antioxidant activities of the extracts were also done using DPPH, nitric oxide and hydrogen peroxide assay. The phytochemical studies revealed the presence of alkaloids, flavonoids, glycosides and tannin. The results indicate that ethanolic extract has the highest percentage anti-inflammatory activity (78%) when compared to other extracts with an...
Read More
Posted by admin on Oct 31, 2023 in |
Remogliflozin Etabonate, Metformin, Vildagliptin are anti-diabetic drugs. It inhibits the sodium-glucose transport proteins (SGLT), which are responsible – for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Several attempts were made on simultaneous analysis of Metformin with either Vildagliptin or Remogliflozin but no work were carried out on simultaneous analysis of all three drugs combination. In the present work, efforts are made to develop a simple new accurate, precise and linear reverse phase high performance liquid Chromatographic (RP-HPLC) method for simultaneous estimation of Remogliflozin etabonate (RGE), Metformin (MET) and Vildagliptin (VGN) in bulk drug and marketed tablet formulation Different analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization ICH Q2B guidelines. Chromatographic separation was achieved on Acclaimed Mix Mode HILIC-1 column (150 mm × 4.6 mm, 5µm) applying an isocratic elution based on 20 mM ammonium acetate: acetonitrile (75:25, v/v) as a mobile...
Read More
