Posted by admin on Feb 29, 2024 in |
The stressed degradation study of Ciclesonide was conducted using various conditions, including acid, base, photolytic, thermal, and oxidative degradation. LC-MS was employed to characterize the degradants formed during these stress conditions. To assess the stability of Ciclesonide under stress, the study followed the guidelines outlined in ICH Q1A (R2). During the analysis, a C18 column (250mm x 4.6ID, 5 Micron) was utilized with a mobile phase of methanol: water (95:05) pH 3, adjusted with Ortho phosphoric acid, flowing at a rate of 0.9 ml/min. The analysis was performed using a PDA detector at an ambient temperature, with a retention time of 7.5 minutes for the drug. UV detection at 225nm was used for quantification. The results revealed the formation of a significant amount of a new compound under the stress conditions of acid, base, photolytic, and thermal degradation. LC-MS data confirmed the presence of stressed impurities of ciclesonide. This method was successfully applied in quality control laboratories for the determination of Ciclesonide, along with its decomposition...
Read More
Posted by admin on Feb 29, 2024 in |
Background: Medication errors significantly impact patient morbidity and mortality. Due to their specialized expertise, pharmacists are essential in detecting and averting these errors. Methods: This study evaluated pharmacists’ roles in reporting and preventing medication errors at King Faisal Hospital in Makkah, Saudi Arabia. Using a cross-sectional method, we analyzed medication error reports to understand the rate, causes, and types of errors during the study period. A questionnaire further probed pharmacists’ interventions in reducing these errors. Results: Of the 45 pharmacists surveyed (average age: 34.91 ± 3.9 years), 1,738 medication errors were reported between September 2021 and July 2022, peaking in October 2021. Key causes were prescribing errors (26%), dispensing errors (16%), and dosing errors (10%), with the remaining 48% attributed to various other factors. Common interventions included liaising with physicians for emergency order verification, preventing unintended dispensation, and correcting dosing mistakes. Conclusion: Predominant medication errors arose from prescribing, dispensing, dosing, omission, improper dosage, and incorrect frequency. Miscommunication in drug orders, characterized by illegibility or ambiguity, was a major error...
Read More
Posted by admin on Feb 29, 2024 in |
Moringa oleifera is one plant that is multi-purposefully used for the prevention and treatment of numerous diseases. This study analyzed the phytochemical and elemental contents of M. oleifera leaf extract, and evaluated its effect on fibroblast proliferation, which is crucial for wound healing. M. oleifera leaf samples were collected, identified, and extracted using solvents of different polarities. High-performance thin-layer chromatography (HPTLC) and ultra-high-performance liquid chromatography (UPLC) were employed to analyze the phytochemical composition, while inductively coupled plasma-optical emission spectrometry (ICP-OES) was used to determine the elemental content. The effect of the hydroethanolic extract was investigated on proliferation of Hs27 fibroblast skin cells by the MTT assay. Water extraction yielded the highest extract of 13.0±3% w/w, while petroleum ether extraction yielded the least of 3.03±0.8% w/w. HPTLC fingerprinting of the 50% hydroethanolic extract identified bioactive compounds including flavonoids, phenol carboxylic acids fatty acids, and sterols. UPLC analysis confirmed the presence of rutin and kaempferol in the extract. Elemental analysis showed a high concentration of Ca, K, Br, Mg, and P...
Read More
Posted by admin on Feb 29, 2024 in |
Introduction: Topical corticosteroids are mainstay of treatment for many skin conditions but extensive prescription of them may lead to increase in adverse reactions. So, periodic audit of prescriptions will help in enhancing the therapeutic effectiveness and reduce the adverse effects. Objective: To study sociodemographic data and drug prescription pattern in patients with skin diseases. Methodology: Prospective observational drug evaluation type of study conducted at tertiary care teaching hospital during January to December 2018. Secondary data analysis was conducted of 500 prescriptions of dermatologists which were selected randomly in semi structured proforma. Data was analysed as counts and percentage. Results: Total 1551 drugs were prescribed to 500 patients visiting dermatology Outpatient department. Most frequently in 180 prescriptions, 3 drugs were prescribed. Antiallergic are most frequently prescribed drugs (24.3%) followed by Steroids (15.7%). In almost all prescriptions Generic name of drugs, Strength and Duration of treatment were mentioned. Among prescribed steroids topical corticosteroids were prescribed in 69.1% of prescriptions and in topical corticosteroids Clobetasol propionate forms more than half part (53.3%)...
Read More
Posted by admin on Feb 29, 2024 in |
Normally and often skin infections present therapeutic challenges to practitioners and researchers due to the growing concern regarding multi-drug resistant bacterial, Viral, and Fungi Strains. The Antibacterial properties of zinc sulphate and copper sulfate are well known and have been investigated for many previous years. However, the synergistic effect between both metal ions as antibacterial ingredients has not been evaluated in topical formulations like gels and creams. The aim of the present study to formulate cream and gels containing zinc and copper individually or in combination and evaluate the in-vitro antibacterial activity of these metal ion in the formulation. Zinc sulfate and copper sulfate had a strong synergistic antibacterial activity in cream and gels. By evaluating the various parameters such as pH, Spreadability, viscosity, and antibacterial properties it is confirm that the metal gel and cream enhance the antibacterial activity. This study evaluated and confirmed the synergistic in-vitro antibacterial effect of copper sulfate and zinc sulfate in cream and...
Read More
