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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Dec 31, 2015 in | 0 comments

PHILADELPHIA CHROMOSOME IN PRETHERAPEUTIC CASES OF CHRONIC MYELOGENOUS LEUKEMIA

Chronic myeloid leukemia (CML) is a clonal myel0 proliferative disorder due to neoplastic transformation of myeloid stem cells. The characteristic Philadelphia Chromosome translocation t(9:22) (q 34: q11) juxta poses the c-abl oncogene from chromosome 9 with break point cluster region (bcr) on chromosome 22 resulting in the generation of aberrant bcr/abl transcripts. The abnormal bcr/abl tyrosine kinase gene product has enhanced activity compared to the wild type c-abl tyrosine kinase and is believed central to the pathogenesis of CML. Most of the patients in chronic phase who are treated with cytotoxic agents eventually develop a fatal blast phase that is the end stage in which the patient usually fails to respond combination chemotherapy and only treatment remain after that is allogenic bone marrow transplantation. Since the philadelphia chromosome is the most consistant abnormality in CML patients and as it possess both diagnostic as well as prognostic importance, it’s detection is mandatory to establish the diagnosis of CML and for planning of chemotherapy. Our study is a preliminary work to...

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SYNTHESIS OF HETEROCYCLIC NITROGEN COMPOUNDS BY CLOSURE REACTIONS USING TETRAACETYLETHANE WITH VARIOUS PRIMARY AMINES

This work includes synthesis of new five, six, and seven-heterocyclic nitrogen compounds by closure reactions of tetraacetylethane (3) with primary amines in refluxing ethanol and acetonitrile as solvents and without using any catalysts. The tetraacetylethane melting point 184-189 ºC was prepared by condensation of two anhydrous molecules of sodium salt of acetylacetone and in the presence of dry ether as solvents and Iodine as a catalysts. The heterocyclic nitrogen compounds as: 1,4,5,8-tetramethyl-4a,8a-dihydropyridazino[4,5-d]pyridazine (11), 3,7-bis (2,4-dinitrophenyl)1,4,5,8-tetramethyl-4a,8a- dihydropyridazino [4,5-d]pyridazine (12), 1,4,5,8-tetramethyl-1,4a,5,8a-tetrahydro-oxazino[4,5-d]oxazine (13), 4,4′,6,6′-tetramethyl-[5,5′-bipyrimidine]-2,2′(5H,5H’)-dione (14), 2,2′,4,4′-tetramethyl-3H,3H’-3,3′-bibenzo[b][1,5]diazepine (15), (4,6-dimethyl-1, 3 dimethyl enepyrrolo[3,4-c]pyrrole-2,5-diyl)bis(ethan-1-amine) (16), 4,4′-(4,6-dimethyl-1,3-dimethylene pyrrolo[3,4-c]pyrrole 2,5-diyl) dibenzoic acid (17), 2,5-bis(4-bromophenyl)-4,6-dimethyl-1,3-dimethylene-pyrrolo[3,4-c] pyrrole (18), 1,1′-((4,6-dimethyl-1,3-dimethylenepyrrolo[3,4-c] pyrrole -2,5-diyl) bis (4, 1-phenylene)) bis (ethan-1-one) (19), were prepared via condensation of compound (3) with primary amines (e.g. , hydrazine hydrate and primary aromatic amines) in 1:2 molar ratios. The compounds (11-19) were also synthesized by microwave irradiation of starting materials without using any solvent to give excellent yields of these compounds ranging between 80-95. Compounds (11-19) have been identified by spectroscopic methods, IR, UV, 1H-NMR, 13C-NMR (DEPT. 90...

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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL α-AMINOPHOSPHONATES BEARING A QUINOLINE MOIETY

A novel aminophenylaminoquinoline analogues have been synthesized starting from 4,7 dichloroquinloine and (p-phenylenediamine 2a, o-phenylenediamine 2b or m-phenylenediamine 2c). The one pot reaction with aldehydes and triphenylphosphite in presence of LiClO4 as a Lewis acid catalyst led to the formation of novel α-aminophosphonate derivatives bearing quinoline moiety in good yields. The synthesized compounds have been characterized on the basis of the spectral analysis.  All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed a potency against both gram positive and gram negative...

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LORNOXICAM AND FRANKINCENSE OIL TRANSDERMAL GEL: A POTENTIAL FORMULATION FOR MANAGEMENT OF INFLAMMATION

Inflammation is usually accompanied by pain. The pathogenesis of pain involves not only nociception i.e. the aspect related to sensation of pain but also the emotional aspect involving the pain related fear and stress. Lornoxicam is a non-steroidal anti-inflammatory drug of oxicam class. Frankincense oil, used commonly in aromatherapy, has been known to have calming and grounding effect on emotions. The aim of this study was to provide a formulation for topical application which has a potential as an effective alternative for better management of inflammation. Gel formulation of lornoxicam, 0.5%w/w, was optimized. Lornoxicam gel formulation containing frankincense oil was prepared. The effect of addition of frankincense oil on physical properties of the gel and drug permeation was studied. Anti-inflammatory activity of the developed lornoxicam gel containing frankincense oil was demonstrated. The in-vitro diffusion studies showed a higher and faster release of lornoxicam from the gel containing frankincense oil than that from the gel without frankincense oil.  The flux obtained for lornoxicam in ex-vivo permeation studies was higher for...

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IN-VITRO ANTIOXIDANT EFFECTS OF TANNIN EXTRACTS OF PISTACIA ATLANTICA

Seven parts of Pistacia atlantica were collected from Tlemcen in Algeria (fruits, leaves, buds, stems, roots internal and external trunk barks). Tannin content was determined and antioxidant activity of tannic extracts were measured using different assays: Total antioxidant capacity, 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power (FRAP) and β-carotene bleaching assay The results showed that the highest tannin contents were observed in roots(49.789±0.391 mg CE/g DM) and internal trunk barks (49.095±0.306 mg CE/g DM). Tannins extracted from leaves, roots and external trunk barks showed very good DPPH radical scavenging activity (IC50 of 0.124±0.001, 0.304±0.001 and 0.440±0.001 mg/mL), ferric reducing power (0.021±0.001, 0.154±0.001 and 0.170±0.005 mg/mL) and β-carotene bleaching inhibition (0.313±0.009, 0.094±0.006 and 0.131±0.002 mg/mL), respectively. Therefore, the results suggest that this plant with all its studied parts might be considered as a potential candidate of possible health-promoting functional...

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