Posted by admin on Oct 31, 2023 in |
The epidermal growth factor receptor is a tyrosine kinase receptor and its overexpression triggers cancers. EGFR inhibition is one of the most unique and popular technique for cancer treatment. There are various approved EGFR inhibitors like osmertinib, lapatinib, afatinib, etc. Huge natural products are discovered every year and Rhamnocitrin derivative Tupichinol E obtained from the Northern Sikkim plant Tupistra nutans is structurally similar to EGFR inhibitors. Structurally similar EGFR inhibitors, their modes of binding and mechanism of actions are a new way to select lead compounds for better alternatives. Therefore molecular docking is done to find a potential anti-EGFR flavonoid. Osmertinib shows binding energy -107.23 kcal/mol with EGFR, while Tupichinol E shows binding energy -98.89 kcal/mol. Tupichinol E shows 1.5 times more binding affinity than osmertinib. The compound binds to the EGFR at the same exact position as osmertinib and has the same docking poses. Tupichinol E binding to EGFR stabilises the protein structure and is a pharmacologically active substance that can be used against cancer due to its...
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Posted by admin on Oct 31, 2023 in |
Dolutegravir, an integrase strand transfer inhibitor (INSTI), is a BCS class II, poorly soluble antiretroviral medication that has been licenced by the FDA for the treatment of HIV infections. DTG has a number of drawbacks, including limited oral bioavailability (16%), hepatotoxicity, and instability in an acidic environment. Due to the medication’s limited solubility, 84% of the dose is eliminated from the body after oral administration in an unaltered state. Lipid-based nanoparticles have been chosen for the current research study as a viable drug delivery technology to help with the aforementioned challenges. Melt emulsification sonication procedure was used with CAPMUL MCM EP, Glyceryl monostearate, TWEEN 80, SPAN 80, and other ingredients, a total of six formulations were created. The formulations’ particle size, polydispersity index, zeta potential, drug concentration, drug entrapment effectiveness, in-vitro release, and other factors were assessed. The prepared formulations demonstrated zeta potential of -11.78 to-26.6, in-vitro drug release of between 62 and 80.32 percent, and particle sizes varying from 155 to 205 nm. The best formulation, according to...
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Posted by admin on Oct 31, 2023 in |
Aging is defined as decreased maximal function and reserve capacity in all body, organs, resulting in an increased likelihood of disease and death. One of the reasons for Premature Aging is deficiency of Vitamin D3. The main aim of the research work is to develop and evaluate the Nanoparticle based Anti-aging cream of Vitamin D3 for Premature aging. Six formulations were prepared by Nano precipitation method using Poloxamer 407 as polymeric stabilizer. It was then incorporated into cream base. FT-IR studies were carried out to determine the drug-excipient compatibility. The prepared Nano-suspension was subjected to evaluations including particle size, zeta potential, drug entrapment efficiency and drug content. The formulated cream was tested for pH, Spreadability, Viscosity and in-vitro drug release. From the preliminary trial, F4 was found to be the best formulation. It was then fitted to Box-Behnken design with three independent variables including concentration of Stearic acid (X1), KOH (X2), Glycerine (X3) and two dependent variables – Spreadability (Y1) and In-vitro drug release (Y2). Among the 15 runs,...
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Posted by admin on Oct 31, 2023 in |
Background: Increased anxiety in patients undergoing caesarean delivery has a negative impact on fetus and mother. Music therapy can have beneficial effects. The aim of our study was to determine the effects of preoperative and intraoperative music therapy on anxiety, pain, patient satisfaction and postoperative nausea and vomiting in patients undergoing caesarean delivery under spinal anaesthesia. Methods: A prospective randomised study was conducted on 100 patients, 18–40 years of age, ASA Grade I–III posted for caesarean delivery under spinal anaesthesia. Patients were randomly divided into two groups (50 each). Group M patients listened to soothing meditative flute music, and Group C patients had no music but headphones until the end of the surgery. Observations were recorded and analysed statistically: mean blood pressure (MBP), heart rate (HR), visual analogue score (VAS) for pain, visual analogue score for anxiety (VASA), and patient satisfaction score (PSS). Results: Compared to Group C, HR and MBP in Group M started falling after 10 minutes of spinal anaesthesia, and the difference was significant (p<0.05). Compared...
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Posted by admin on Oct 31, 2023 in |
Introduction: Diabetic neuropathy occurs in about half of the individuals with long-standing diabetes manifested as polyneuropathy, mononeuropathy and autonomic neuropathy. There is evidence indicating the involvement of zinc in diabetes. Aim: To evaluate the effect of Zinc as add-on therapy in Diabetic Neuropathy on the basis of clinical signs and symptoms and glycaemic control. Materials and Methods: This prospective study was conducted in the Department of Pharmacology at Sarojini Naidu Medical College and associated Hospital Agra, Uttar Pradesh, India. A total of 105 patients of either type-1 or type-2 diabetes mellitus with complication of diabetic neuropathy were included and divided randomly into control and study groups of 52 and 53 patients each. Control group received standard anti-diabetic therapy plus Pregabalin 75 mg/day and Methylcobalamin 1500 mcg/day, while the participants of study group received standard anti-diabetic therapy plus Pregabalin 75 mg/day and Methylcobalamin 1500 mcg/day plus Zinc acetate 50mg/day as add-on therapy. Symptoms and signs of sensory-motor neuropathy, autonomic dysfunction and neuropathy were recorded at baseline and on subsequent follow...
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