Posted by admin on Mar 1, 2016 in |
Scope: In recent years, governments and industries worldwide have invested billions of dollars in nanotechnology research and development, and proponents predict that it will offer numerous benefits to society. Objectives: To evaluate the toxicity of Cerium in nanomaterials and in bulk form in rats by repeated daily oral treatment for 28 days by monitoring the effects on animal and also to assess the hematological and various biochemical parameters in serum and targeted biochemical parameters. Results and discussion: The 28 days repeated dose oral toxicity showed CeO2-NM and CeO2-Bulk did not affect the body weight gain and feed intake of the treated rats. Further, CeO2-NM significantly inhibited some of the hematological parameters like platelets count, granulocytes, % hematocrit and biochemical parameters in both male and female rats in dose dependent manner. However, CeO2-Bulk could not induce any significant alterations in these parameters and the changes were near to control in both male and female treated rats. Conclusion: These results suggested that as particle size decreases, showed increased toxicity, even though...
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Posted by admin on Mar 1, 2016 in |
It is well known that main sources of Vitamin D are sun exposure and diet. There is a gap in our knowledge about the contribution of these factors to Vitamin D level among autistic children in Egypt. Aim: To determine Vitamin D dietary intake and sun exposure and their impact on vitamin D level. Methods and procedures: Serum Vitamin D levels were measured in 42 autistic and 40 healthy matched children. Dietary Vitamin D intake and sun exposure hours were collected using an adapted pre-validated food frequency questionnaire. Vitamin D intake was compared with recommended dietary intake (600 IU). Results and outcomes: Autistic children had significantly lower serum levels of 25- hydroxy Vitamin D than healthy children (P < 0.001) with 54.7% and 28.6% being Vitamin D deficient and insufficient, respectively. Dietary Vitamin D intake of both groups was significantly lower than recommended dietary intake. No correlations between serum Vitamin D level and dietary Vitamin D intake or Childhood Autism Rating Scale. Conclusion and implications: Vitamin D deficiency was...
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Posted by admin on Mar 1, 2016 in |
Cancer is a global problem. However, in low-income and developing countries, the expenditures associated with its treatment are increasing disproportionately with resources available. Hence, reducing the drug wastage and financial burden placed on patients, family and society in general is becoming imperative. Our aim was to calculate therapeutic and economic benefits derived by the use of a centralized unit, which allows residual amounts of unused drugs to be reused by patients whose treatments are elaborated in the same working day. We calculated in a comprehensive manner the number of spared vials (flasks) for seven drugs generated from residual amounts of the same working day and, its consequent therapeutic and/or economic benefits. We did not take into account prescribed drug dosages that fitted exactly with doses contained in a vial. Over a six month period, there were: a total of 1524. 07 saved vials with an approximate consequent therapeutic benefit of 123.57 patients and, considering the price of the centralized unit, a total economic benefit of approximately 134, 348 (€),...
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Posted by admin on Mar 1, 2016 in |
Over the last decade the incidence of candidiasis has dramatically increased. To fight candidal infections vaccines with immune modulating properties have been actively investigating in recent years. In our previous studies it was found that the immunobiological drug under the conditional name “Candidocyde” based on the antigens of C. albicans and C. tropicalis fungi possessed the protective and therapeutic effect. The aim of this work is to substantiate experimentally the preservative in the composition of the immunobiological drug based on the antigens of C. albicans and C. tropicalis fungi. Various preservatives (phenol, merthiolate and formaldehyde) in the composition of the immunobiological drug have been studied. Compatibility of the preservative and the immunobiological drug was determined by the antibody titers for preventing and treating candidal infections in mice. The results of the ELISA study when preventing candidal infection have shown that after double injection of the immunobiological drug with phenol in the concentration of 0.25 % and merthiolate in the concentration of 0.01 % as preservatives there is 8 times...
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Posted by admin on Mar 1, 2016 in |
The interaction of losartan potassium (LP) with bovine serum albumin (BSA) was studied by fluorescence quenching in combination with UV–Vis spectroscopic method under near physiological conditions. The fluorescence quenching rate constants and binding constants for BSA–LP system were determined at different temperatures. The fluorescence quenching of BSA by LP is due to static quenching and energy transfer. The results of thermodynamic parameters, ∆H (‒134.3 kJ mol‒1), ∆S (‒368 J mol‒1 K‒1) and ∆G (‒24.52 to ‒20.83 kJ mol‒1), indicated that van der Waals interaction and hydrogen bonding played a major role for LP–BSA association. The competitive experiments demonstrated that the primary binding site of LP on BSA was located at site II in sub-domain IIIA of BSA. The distance between LP and a tryptophane unit was estimated to be 3.183 nm based on the Förster resonance energy transfer theory. The binding constant (Ka) of BSA–LP at 298K was 1.932×104 L mol‒1. Synchronous fluorescence and three-dimensional fluorescence studies showed that the presence of LP could change the conformation of BSA...
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