Posted by admin on Jan 1, 2016 in |
In the present study an attempt has been made to explore radiation and cadmium induced histological alterations in mice liver and their modulation by Emblica officinalis fruit Extract (EOE). For this purpose mice were selected from Inbred colony and divided into five different groups. Group: Ι (Sham-irradiated group) considered as normal; II (cadmium chloride treated group) in this group animals were administered 20 ppm cadmium chloride orally as drinking water; III (irradiated group) animals were exposed to 3.5 Gy gamma radiation; IV (Both radiation and cadmium treated group); V (Radiation, cadmium and Emblica treated group) in this group animals were given 1000 mg/kg body wt/animal/day EOE continuously for seven consecutive days, prior to radiation and cadmium chloride treatment and on the 7th day animals were irradiated after 30 minutes of extract administration. The animals from the above groups were autopsied by cervical dislocation after 1, 2, 4, 7, 14 and 28 days and liver were removed and prepared for light microscopy. The liver cells of irradiated and cadmium treated...
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Posted by admin on Jan 1, 2016 in |
The research was carried out to formulate and evaluate ophthalmic solutions of Ofloxacin with amino acid transporters and compare the transcorneal permeation of Oflaxacin with that of the standard. In the study three different eye drop formulations were prepared by conjugation of the drug with different amino acids such as Alanine, Glycine and Leucine by solvent evaporation technique, the extent of transcorneal permeation of the drug was determined and compared with that of formulated standard Oflaxacin ophthalmic solution. The prepared formulations have been observed to play significant role in the process of maintaining structural and functional integrity of conjunctiva and retina. Permeation characteristics of drug were evaluated by introducing 1 ml of formulation on freshly excised cornea fixed between donor and receptor compartments of an all-glass modified Franz diffusion cell and measuring the drug permeated in the receptor cell by UV at 288nm. After 120 minutes, the permeation of standard Ofloxacin solution was found to be 0.02% and the permeation of the formulated conjugates of Ofloxacin with different amino...
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Posted by admin on Jan 1, 2016 in |
Type II diabetes mellitus is a serious global health problem and is associated with considerable morbidity and mortality. According to International Diabetic Federation, by 2030 there is 1 adult in 10 will have diabetes. To achieve long term glycemic control, multiple drugs including parenteral therapy with insulin and oral drugs are needed. Hyperglycemia, diabetes associated complications and co morbidities are the strong factors that favor therapeutic poly pharmacy and reduced patient adherence. Materials and methods: It was an experimental study with pre test and post test design conducted in the department of General Medicine, Govt Medical College, Kozhikode. Data were collected from OP sheets, laboratory reports and patient interview with medication adherence questionnaire. Adherence questionnaire prepared based on Morisky 8 item medication adherence questionnaire. Results: A total of 218 patients with type 2 diabetes and associated complications were enrolled into the study from January 2013 to May 2013 after signing the written consent form. Medication adherences have been improved after pharmacist intervention. Poor adherence has been reduced from 48.2%...
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Posted by admin on Jan 1, 2016 in |
Chemical protection plays a decisive role in the resistance of plants against various pathogens and their spore germination. The so-called secondary metabolites which are a characteristic feature of plants and are important to protect plants against a wide variety of microorganisms including fungi. In order to this, the present study was carried out to evaluate the antifungal potential of Bryum cellulare aqueous and ethanolic crude extracts against percentage inhibition of spore germination and hyphal length of test fungi Curvularia lunata, the causal organism of leaf spot of Zea mays. The preliminary tests showed that flavanoid, sterols and terpenoids etc are present in the test plant. Further various concentrations of crude extracts of aqueous and ethanolic form were tested against spore germination and hyphal length of C.lunata through hanging drop method. The results showed that all the extracts posses a significant antifungal potential but highest inhibition of percentage in spore germination was observed in ethanolic extract of B.cellulare. The percentage of spore germination was 60.43 and 15.20 in 10 and...
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Posted by admin on Jan 1, 2016 in |
The present study of wound healing activity of mimusops elengi linn was aimed to evaluate this activity of extract of leaves of mimusops elengi. On the basis of traditional use and literature reference, this plant was selected for wound healing activity. A meathanolic extract of leaves of mimusops elengi was examined for wound healing activity in the form of ointment in form of ointment in excision wound model. the ointment of extract of ointment showed considerable response in excision wound model in comparision of a standard drug Betadine ointment in terms of wound contract ability, wound closure time, tensile strength, dry granuloma weight, histological analysis also showed that mimusops elengi leaves extract exhibits significant wound...
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