Posted by admin on Oct 31, 2023 in |
Annona squamosa (sugar apple) is commonly cultivated in tropical South America occasionally in southern Florida as well as in Jamaica, Puerto Rico, Barbados, and dry regions of Australia. It was growing in Indonesia early in the 17th century and has been widely adopted in southern China, tropical Africa, Egypt, and the lowlands of Palestine. This plant is a small well-branched tree or shrub that bears edible fruits called sugar-apples, species of the genus Annona and a member of the family Annonaceae is traditionally used for the treatment of epilepsy, dysentery, cardiac problem, warm infection, constipation, hemorrhage, antibacterial infection and also has anti-tumor activity. Especially the seeds have another important effect they are medically useful to show many therapeutic activities such as anticancer, and CNS depressant. Hence the present study was taken to test the antimicrobial activity of seeds of Annona squamosa and microbes such as Staphylococcus aureus and Salmonella typhi. The evaluation of the antimicrobial activity of the seed extracts of Annona squamosa was done with methanol using the...
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Posted by admin on Oct 31, 2023 in |
People utilise plants regularly all around the world for the treatment and prevention of a wide range of illnesses. One abundant plant found in India is the banyan tree, Ficus benghalensis Linn. Oral and dental hygiene is the primary factor of a human being to lead a healthy life. The aim of this study is to design Ficus benghalensis Linn. candy to improve patient oral health, toothache, and acceptability. Ficus benghalensis latex was collected from market for preparation of candy for toothache. There were nine different Ficus benghalensis preparations made. Ficus benghalenis, latex, citric acid, methyl cellulose, glycerin, β-cyclodextrin, and isomalt were used in varying concentrations to create the candy. Formulation F1, F3, F6, & F8 depicted better result as compared to other formulation as they were flexible. The hardness, friability, weight fluctuation, and solubility of all of the formulations were within acceptable ranges. Due to its lack of major adverse effects and promising medicinal applications, the genus Ficus assumed to be safe for long-term pharmacotherapeutic use in...
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Posted by admin on Oct 31, 2023 in |
Chenopodium album, Chenopodium murale, and Chenopodium giganteum are annual herb. Almost 250 different species of Chenopodium can be found all over the world. They are grown for many purposes, including some for their green leafy vegetables and others for the grains they provide. The phytochemicals, proteins, carbohydrates, tannins, flavonoids, alkaloids, steroids, terpenoids, and saponins have attracted a lot of interest because of their significant application to the preservation of human health. The present study deals with phytochemical screening and measuring antioxidant potential on the extract of root, stem, and leaf of selected Chenopodium species. The antioxidant potential was analyzed using the ferric-reducing antioxidant power (FRAP) assay activity. The antioxidant capacity of the root, stem and leaf extracts increased with increasing concentration; the values calculated µmol/ml FeSO4 equivalent (µmol/ml FeSO4/gdw) using a standard curve. Using recognized methodologies and procedures, the phytochemical analysis of the various extracts of Chenopodium album, Chenopodium murale, and Chenopodium giganteum was...
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Posted by admin on Oct 31, 2023 in |
Floating microspheres have been showing high potential for gastro retention and provide an efficient means of enhancing bioavailability and controlling the release of drugs. Metformin hydrochloride is an effective antidiabetic that required controlled release due to its Short half-life of about 4.5-7 hours and bioavailability 50-60 %. The present research works aim is to develop, evaluate and statistically optimize the Metformin hydrochloride loaded floating microspheres for treatment of type 2 Diabetes mellitus. Six formulations were prepared by ionotropic gelation method by using various polymers such as HPMC K 100 M, Carbopol 934 P, Sodium bicarbonate etc and natural polymers such as tamarind gum powder and neem gum powder. The prepared microspheres were analyzed for particle size, surface morphology, % yield, % drug entrapment efficiency, in-vitro buoyancy, in-vitro drug release studies, in-vitro drug release kinetics, stability studies etc. From the preliminary trial, F4 Formulation was found to be the best formulation with Particle size of 820± 6.15 µm, in-vitro buoyancy of 95.6% and in vitro drug release of 76.33%. From...
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Posted by admin on Oct 31, 2023 in |
Water solubility is the rate limiting step in dissolution and bioavailability. Olmesartan medoxomil is BCS class-II drugs having low water solubility. Olmesartan medoxomil acts on cardiovascular system and used in the treatment of hypertension as antihypertensive agent. Olmesartan medoxomil have low water solubility and low bioavailability as 26%. In this research study we made Olmesartan medoxomil solid dispersion for increasing water solubility of Olmesartan medoxomil. HPMC and PVP were used as hydrophilic polymer while Lyophilization technique was used as a method of preparation of solid dispersion. We evaluated the effects of freeze drying in process yield, solubility and total Olmesartan content of the solid dispersion. This solubility study shows significant increase in solubility of solid dispersion of Olmesartan medoxomil than pure Olmesartan medoxomil. Dissolution study illustrate that, there was improved dissolution rate when compared to plain Olmesartan. The result and conclusion of this research suggest that the solid dispersion prepared in this research has successfully improved the solubility of Olmesartan...
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