Posted by admin on Nov 30, 2015 in |
The antioxidant activities of five wild edible fruits e.g. e.g. Debregeasia longifolia, Helicia erratica, Ilex venulosa, Rhus semialata and Spondias axillaris collected from Meghalaya state in India were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content and flavonol content. The solvent systems used were benzene, chloroform, acetone and methanol. The different levels of antioxidant activities were found in the solvent systems used. The results indicate that these wild edible fruits could be utilized as natural...
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Posted by admin on Nov 30, 2015 in |
The study presents a simple and rapid chromatographic technique for the estimation of chlorhexidine gluconate for mouth wash using a combination of phosphate buffer and acetonitrile as mobile phase. The separation was carried out on a stainless steel column 250mm × 4.5mm packed with octadecyle silane particles. The detection was carried out using a dual lambda absorbance detector at 254nm wavelength. The method is found to be linear in the concentration range 10.56µg/ml to 98.56µg/ml and correlation coefficient 0.998. The analyte peak was found to be symmetric and the average retention time is 2.919mins. The method was found to selective, precise and accurate for the quantification of the drug from mouth rinse available in the...
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Posted by admin on Nov 30, 2015 in |
A preliminary experiment was carried out to analyse the growth performance of Agrocyba aegerita mushroom cultures using chemosynthetic media. This study is mainly aimed to different media such as Yeast Malt Agar Medium (YMA), Saboraud’s Dextrose Agar Medium (SDA), Glucose Peptone Agar Medium (GPA), Malt Extract Agar Medium (MEA) and Potato Dextrose Agar Medium (PDA) on the growth of mycelium of the mushroom. Studies revealed that the joint portion of cap and stripe produced vigorous mycelium growth in minimum time; the average maximum growth was obtained on Malt Extract Agar (MEA) than Potato Dextrose agar (PDA)...
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Posted by admin on Nov 30, 2015 in |
The main objective of the present work is to develop Floating Effervescent matrix tablets of Ranitidine hydrochloride using different polymers viz. hydroxy propyl methyl cellulose (HPMC), Xanthan gum and Guar gum. Varying ratios of drug and polymer like 1:0.6 and 1:1 were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rate controlling material. After evaluation of physical properties of tablet, in-vitro buoyancy studies, Swelling index and in vitro release study were performed in 0.1N Hcl up to 12 hrs. Dissolution data was analyzed by Korsmeyer-Peppas power law expression and modified power law expression. It was observed that matrix tablets contained polymer blend of HPMC K100M/Guar gum were successfully sustained the release of drug upto 12 hrs. Among all the formulations, formulation F9 which contains 50% HPMC K100M and 50% of Guar gum has released the drug which follow Zero order kinetics via, swelling, diffusion and...
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Posted by admin on Nov 30, 2015 in |
The present study was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compression coated tablet formulation 7.5% : 7.5% ethyl cellulose:cellulose acetate phthalate showed controlled drug release, were formulation showed no evidence of drug release in pH 1.2, but drug released was in simulated intestinal fluid pH 7.4 after 5 hours, further drug release continued in pH 6.8 i.e. pH of colon for 24 hours and was 87.38% after 24 hour, suited for colon specific drug delivery, on subjecting the selected formulation to in vitro microbial disintegration studies, the disintegration started within 4 hours of incubation period indicates that the usefulness of pectin in the formulation, were pectin is microbially hydrolysable and complete disintegration was observed after 16 hours. In vivo oral disintegration/ degradation the result...
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