Posted by admin on Mar 1, 2016 in |
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability and to increase the residence time of drug by bringing the drug in the vicinity of absorption window by formulating it in mucoadhesive drug delivery system. An attempt has been made to increase the bioavailability of Norfloxacin by formulating mucoadhesive suspension in different Polymers. Increase in time, speed of homogenization decreases the particle size and increases the zeta potential. Batches formulated with soyalecithin, antinucleating agents, showed decreased particle size. The comparative studies of dissolution studies showed, 99.55% of processed suspension released in 10Min. as compared to 101.63% released in 40Min. for marketed suspension respectively. The reason for increased percent release of drug in short time (10Min.), for processed suspension is, more...
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Posted by admin on Mar 1, 2016 in |
The plant Hugonia mystax L., is a woody evergreen liana belonging to the family Linaceae, locally knows as Modirakanni. Ethnobotanically the tender fruits were used for rheumatism and biological activities like antimicrobial were reported. Present study find outs the scientifically evidence of fruits of Hugonia mystax for its antioxidant property. The different extract of fruits was obtained by successive extraction with petroleum ether, chloroform and ethanol by soxlet method. These extracts were taken for an in- vitro antioxidant study, was carried out by using various in vitro antioxidant screening models like DPPH radical scavenging activity, total phenolic content was determined. The successive plant extract showed good dose dependent activity by inhibiting DPPH and total phenolic content. Antioxidant activity of fruits showed a greater free radical sequestering activity. In the present study, ethanol extract showed a greater antioxidant activity was found to be 1000 µg/mL expressed as significant antioxidant activity of Hugonia mystax. This might be due to the presence of phytocompounds flavonoids, phenols, saponins, steroids, tannins and terpenoids present...
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Posted by admin on Mar 1, 2016 in |
To provide a scientific basis to traditional uses of seeds of Anethum graveolens, seed extract was evaluated for its antioxidative potential. Firstly, indeed, aqueous extract of Anethum graveolens was prepared and analyzed for the phytochemical compounds contents. Furthermore, antioxidant activity was assessed using the Total Antioxidant Capacity (TAC) methods: 2.2’Azinobis (3-ethylbenzthiazoline-6-sulfonic acid (ABTS. +), 2, 2-Diphenyl-1-picrylhydrazyl (DPPH.+), Ferric reducing antioxidant power (FRAP) and also the Hydroxyl Radical Scavenging Activity (HRSA) assays. The total phenolic, catechins and tannins contents of this extract were also assessed. Finally, the protection effect on DNA damage was evaluated. Results obtained by all of the radical scavenging activity methods used showed higher antioxidant activity. Also, the results indicate that the extracts of A. graveolens showed stronger hydroxyl radical scavenging activity with an inhibition percentage of 43.56 %. However, results obtained showed that the extract was not providing a protective effect upon DNA fragmentation by the method...
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Posted by admin on Mar 1, 2016 in |
A gradient reverse phase Ultra Performance Liquid Chromatographic (RP-UPLC) method was developed and validated for determination of Micafungin sodium and its synthetic impurities. The successful separation of Micafungin sodium and its synthetic impurities was achieved using Phenomenax Aeris peptide XB C18 (150×2.1 mm i.d., 1.7 µ particle size) column maintained at 45 °C temperature with mobile phase consisting 0.01 M phosphate buffer pH 2.9 and acetonitrile in a gradient programme. The mobile phase flow rate was 0.3 ml/min and the detection wavelength was 279 nm. The retention time in developed method is comparatively less than the reported HPLC methods for determination of Micafungin sodium offering less time consuming and fast analytical method. The developed RP-UPLC method was validated according to ICH guidelines with respect to linearity, accuracy, precision, specificity and robustness and also the LOD and LOQ values were...
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Posted by admin on Mar 1, 2016 in |
Women on different contraceptive methods have been linked with the development of various changes in lipids profile. Therefore, the relationship between contraceptive use and lipids changes needs to be investigated. Method: This was a cross-sectional randomized study conducted on non-lactating, non-pregnant women who were on different methods of contraceptives for at least a period of 6 months and were attending the Family Planning room at Al-shomaly hospital south of Babylon government. The study population consisted of a countryside population. One hundred twenty-five divided into five groups 25 women each group: (1): taken oral contraceptive (microgynon tablet), (2) taken oral contraceptive (microgynon tablet) with 400 IU Vitamin E per day, (3) on injectable contraceptive (depo Provera), and (4): on injectable (depo Provera) with 400 IU Vitamin E per day and (5): not taken any things as control individuals. Conclusion: contraceptives have a series role in elevation of lipids profiles, and use of Vitamin E can reduce a degree of these...
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