Posted by admin on Oct 31, 2023 in |
Aim & Background: Body fluids are sent to clinical microbiology laboratory for culture to find the etiological agent causing the infection. This study was conducted to compare the culture results of sterile body fluids processed simultaneously by both conventional method and BACTEC blood culture system. Methods: Sterile body fluids except blood were included in the study. A total of 61 body fluid samples were received and simultaneously processed by both the culture methods-conventional and BACTEC. Results: In this study, overall culture positivity for BACTEC was 85.25% as compared to 59.02% by conventional system. According to the results of our study, the overall culture positivity was increased by 26.23% by BACTEC method than the conventional method. BACTEC blood culture system detected more pathogenic isolates (52.45%) than the routine conventional culture method (21.31%) and it was found to be statistically significant (p value=<0.005). The most common pathogenic micro-organisms detected by conventional and BACTEC methods in this study were Gram-negative followed by Gram-positive. The mean time to detection of pathogenic isolates by...
Read More
Posted by admin on Oct 31, 2023 in |
Objective: The present investigation aims to develop pH-independent mucoadhesive pellets using the extrusion-spheronization procedure and the inter-polyelectrolyte complex (IPEC) of Chitosan-Carbopol 71G. Miconazole was used as a representative drug in this study. Materials and Method: It was found that the composition of the formulation impacts the extrusion of the prepared dough mass. The generation of pellets within a narrow size range was also studied as a function of spheronization speed and time. The precipitation method was utilized to create IPEC. Compatibility between the drug and the additives was confirmed through FT-IR and DSC testing. Results: The MP3 formulation demonstrated consistent swelling across a wide pH range, without any abrupt alterations in swelling at the pH study points of 4.5 or 7. Evidence from in-vivo X-ray scans indicated that the pellets remained intact in the vaginal canal for an approximate duration of 8 hours. Short-term stability studies of the formulation affirmed its consistency throughout the investigation. Conclusion: The study showed that a Chitosan-Carbopol 71G interpolymer complex can function as a...
Read More
Posted by admin on Oct 31, 2023 in |
The aim of this research was to develop and evaluate a cubosomal gel for the treatment of skin diseases such as athlete’s foot (tineapedis), ringworm (tineacruris) and ringworm (tineacorporis). To increase the penetration of the drug and to provide longer duration of treatment this study was performed. Cubosomes are a novel nanoparticle system loaded with butenafine hydrochloride as an antifungal agent. Cubosomes were designed and approached using a top-down approach. Top-down approach was easy and repeatable also. Cubosomes loaded with Butenafine hydrochloride were prepared by a simple emulsification method using different concentrations of lipid phase GMO and poloxamer 407 enclosed in a cubic gel matrix. The prepared cubosomal dispersion was characterized by Drug Entrapment efficiency and particle size. Optimal formulation of cubosomes were incorporated into carbopol-based hydrogels to form cubosomes hydrogels (cubosomal-gels) characterized by physical morphology, drug release studies, pH, viscosity, and spreadability studies. Among all formulations (F7), was found to have the highest drug release at 24 h of 78.693±0.117%, entrapment efficiency (86.517±0.146) and particle size of...
Read More
Posted by admin on Oct 31, 2023 in |
Inflammation and pain have all been successfully treated using nonsteroidal anti-inflammatory drugs. Today’s nonsteroidal anti-inflammatory drugs (NSAIDs) are typically taken with restriction due to the gastric intolerance they create. The prodrug approach is quite effective in reducing the side effects caused by NSAIDs. Many nonsteroidal anti-inflammatory drug molecules have been modified in several ways so that they can be less hazardous to the stomach. Using the mutual prodrug concept, the side effects can be minimized by covalently bonding the NSAIDs to the second pharmacologically active carrier. The goal of the current study is to use the coupling approach to create mutual ester prodrugs of NSAIDs (MS and MP) in order to overcome the troubles, they cause, like gastrointestinal toxicity, ulcerogenic side effects, etc. The prodrugs were made by using a better reagent, EDAC 1-Ethyl-3-(3-Dimethylaminopropyl) carbodiimide hydrochloride, because it outperformed DCC (N, N′-Dicyclohexylcarbodiimide) as a coupling agent. The physiochemical properties were determined, and the structures of the synthesized prodrugs were confirmed and analyzed by UV, FT-IR, 1HNMR, 13CNMR Spectroscopy and...
Read More
Posted by admin on Oct 31, 2023 in |
Introduction: Balance is an integral component of daily (functional) activities. It is very sensitive, complex and multifactorial. It is the ability to maintain the projection of the body’s centre of mass within manageable limits of the base of support, as in the standing or sitting or in transit to a new base of support, as in walking pattern (1). In old age ability to maintain balance is low and fall is frequent. Objectives: To determine the efficacy of balance training over old age individuals. Inclusion Criteria: Age > 65 years, no gender difference, independent ambulation and activity of daily living. Exclusion Criteria: Chest pain, cancer, amputation, cognitive impairments, neurological condition, fractures. Methods and Procedure: This study was conducted among 50 elderly people. It is randomized control trial, allocated into 2 groups as follow; experimental group and control group. Intervention was given to the subjects 3 times per weeks in 8 weeks. Subjects were assessed before and after. Control group activity included either usual activities or recreational activities. All participants...
Read More
