Posted by admin on Nov 30, 2015 in |
A preliminary experiment was carried out to analyse the growth performance of Agrocyba aegerita mushroom cultures using chemosynthetic media. This study is mainly aimed to different media such as Yeast Malt Agar Medium (YMA), Saboraud’s Dextrose Agar Medium (SDA), Glucose Peptone Agar Medium (GPA), Malt Extract Agar Medium (MEA) and Potato Dextrose Agar Medium (PDA) on the growth of mycelium of the mushroom. Studies revealed that the joint portion of cap and stripe produced vigorous mycelium growth in minimum time; the average maximum growth was obtained on Malt Extract Agar (MEA) than Potato Dextrose agar (PDA)...
Read More
Posted by admin on Nov 30, 2015 in |
The main objective of the present work is to develop Floating Effervescent matrix tablets of Ranitidine hydrochloride using different polymers viz. hydroxy propyl methyl cellulose (HPMC), Xanthan gum and Guar gum. Varying ratios of drug and polymer like 1:0.6 and 1:1 were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rate controlling material. After evaluation of physical properties of tablet, in-vitro buoyancy studies, Swelling index and in vitro release study were performed in 0.1N Hcl up to 12 hrs. Dissolution data was analyzed by Korsmeyer-Peppas power law expression and modified power law expression. It was observed that matrix tablets contained polymer blend of HPMC K100M/Guar gum were successfully sustained the release of drug upto 12 hrs. Among all the formulations, formulation F9 which contains 50% HPMC K100M and 50% of Guar gum has released the drug which follow Zero order kinetics via, swelling, diffusion and...
Read More
Posted by admin on Nov 30, 2015 in |
The present study was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compression coated tablet formulation 7.5% : 7.5% ethyl cellulose:cellulose acetate phthalate showed controlled drug release, were formulation showed no evidence of drug release in pH 1.2, but drug released was in simulated intestinal fluid pH 7.4 after 5 hours, further drug release continued in pH 6.8 i.e. pH of colon for 24 hours and was 87.38% after 24 hour, suited for colon specific drug delivery, on subjecting the selected formulation to in vitro microbial disintegration studies, the disintegration started within 4 hours of incubation period indicates that the usefulness of pectin in the formulation, were pectin is microbially hydrolysable and complete disintegration was observed after 16 hours. In vivo oral disintegration/ degradation the result...
Read More
Posted by admin on Nov 30, 2015 in |
Caesalpinia mimosoides Lamk. is a prickly climbing shrub belongs to Leguminosae family. various parts of this plant have been used in the treatment of ulcer, inflammation, wound healing and arthritis. The present study aimed at the evaluation of anti inflammatory property of different extracts of aerial parts by in vitro and in vivo methods. In vitro methods were estimated by protein denaturation and proteinase inhibition method. An in vivo method was estimated on the carragenan paw edema. Acute toxicity studies were performed as per OECD-423 guidelines. Toxicity signs and symptoms were not observed. Both methods showed significant anti-inflammatory activity of the different extracts...
Read More
Posted by admin on Nov 30, 2015 in |
A simple, accurate, precise and robust reverse phase High Performance Liquid Chromatographic method has been developed and validated for the estimation of Withaferin-A in polyherbal formulation namely Ranger Capsule. The chromatographic method was carried out isocratically with Phenomenex Luna C18 (2) (4.6 x 250 mm, 5 μ) and good resolution was achieved with acetonitrile: water (60: 40v/v) mobile phase. Withaferin- A was detected at retention time 4.04 min using flow rate 1.0 ml/min with UV detection at 230 nm. The calibration curve was achieved to be linear over a range of 2-20 μg/ml with regression coefficient of 0.9993. The proposed method was found accurate with 99.43 % – 100.64 % recovery. Relative standard deviation of repeatability, intra-day and inter-day variations were found to be 0.79 %, 0.12-1.55 %, 0.04-1.73 %, respectively. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were observed to be 0.05 μg/ml and 0.16 μg/ml, respectively. This results shows that method was well validated. In the present study, Withaferin- A was found 80 µg...
Read More
