Posted by admin on Sep 30, 2015 in |
Chenopodium ambrosioides Linn, member of the National List of Medicinal Plants of Interest to SUS (RENISUS), is used to treat different diseases and shows good potential to generate products of interest to the Brazilian Unified Health System “Sistema Único de Saúde” (SUS). However, the use of herbal derivatives implies the control of their quality and the evaluation of their toxicity. Pharmacopeial tests were performed aiming at the physicochemical and microbiological characterization of leaves and extract of C. ambrosioides. The toxicity of the extract was assessed using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) and acute toxicity was assayed in mice. The results showed that the leaves and the extract presented acceptable pharmacopeial parameters and the preliminary phytochemical analysis showed the presence mainly of saponins, terpenes, phenols and tannins in the hydroethanolic extract of C. ambrosioides. The microbiological evaluation of the extract indicated no apparent growth of pathogenic microorganisms. Although the extract showed cytotoxicity at high concentration, no signs of acute oral toxicity could be observed at the tested doses. These results, besides the...
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Posted by admin on Sep 30, 2015 in |
A new potential allelochemical (A) m.f. C34H42O19, m.p 168-170 ◦C, [M]+ 754 (FABMS) along with two known compounds Scutellarin 7-O-β-D-glucopyranoside (B), Luteolin (C) were isolated from methanolic extract of the stems of Cassia Siamea Lam. The structure of a new allelochemical (A) was characterized as 3,7-dihydroxy-5,3′,4′-trimethoxyflavone-3-O-β-D-xylopyranosyl-7-O-α-L-rhamnopyranosyl(1→4)-O-α-L-arabinopyranoside, on the basis of extensive spectroscopic analysis, colour reactions and various chemical degradations. Compound A exhibited higher radical scavenging activity in the (DPPH) (1,1-diphenyl-2-picrylhydrazyl) assay...
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Posted by admin on Sep 30, 2015 in |
Anti-stress activity of hydro-alcoholic extract of Sauropus androgynous leaves was investigated against experimentally induced stress in rats using forced swimming endurance test and chronic cold restraint stress test. Acute toxicity study was performed and hydro-alcoholic extract of Sauropus androgynous leaves was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg (SALE-200) and 400 mg/kg (SALE-400) of the extract was subjected to the evaluation of anti-stress activity. The parameters like cholesterol, triglycerides and corticosterone were estimated to determine the anti-stress activity. The animals pre-treated with SALE-200 and SALE-400 significantly restored the altered biochemical and physical parameters, when compared with stress control group. In addition the histopathology of the adrenal gland also confirmed the anti-stress activity of the extract as the SALE-400 treated groups showed significant recovery and SALE-200 treated groups showed moderately significant recovery of architecture of the adrenal gland. However, the maximum activity was observed at 400 mg/kg bodyweight. The findings of the present study concluded that the hydro alcoholic extract of Sauropus...
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Posted by admin on Sep 30, 2015 in |
Kawasaki Syndrome (KS) can be a widespread vasculitis affecting many systems, and some of the other recognized complications are discussed, including those affecting the skin, nervous system, gastrointestinal tract, musculo-skeletal system, kidneys, lungs, eyes and haematological effects. There is no specific diagnostic test or pathognomonic clinical features; those previously mentioned clinical criteria have been established to assist physicians in diagnosing Kawasaki disease (KD). We are reporting a case of 1 year 3 months child who has successfully relieved by the IgG and Aspirin therapy. A greater awareness on the part of paediatricians is now contributing to increased recognition of this entity even in India. We suggest that physicians should be cognizant of the fact that they must individualize every patient’s management to the best of their knowledge and judgment, rather than merely going by the...
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Posted by admin on Sep 30, 2015 in |
The radioprotective effect of Aloe vera was studied in liver of Swiss albino mice. Animals were divided into three groups. Animals of group I administered double distilled water only, group-II Aloe vera (drug) and control set of group III were given radiation only where as animals experimental set of group III were administered by Aloe vera + Radiation. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure (4.5 GY gamma-radiation).Biochemical parameters such as LPO, GSH, protein, glycogen and cholesterol were assessed at different intervals of post-irradiation i.e. day 1 and 30. Radiation treatment showed decrease in GSH content and an increase of LPO, protein, glycogen and cholesterol observed in control set animals, however the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO, protein, glycogen and cholesterol but values remained below normal. Results suggest that Aloe vera modulate the radiation induced biochemical alterations in Swiss albino...
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