Posted by admin on Sep 30, 2015 in |
Nephropathy is an important comorbidity associated with diabetes leading to chronic kidney disease. We studied the effect of Ocimum sanctum in comparison to Olmesartanmedoxomil, Pitavastatin and their combination in prevention of this comorbidity. Male Wistar rats were given streptozotocin to induce diabetes and randomly divided into groups. Group 1 (Control group) received Metformin (94.5mg/kg/day)+Distilled Water, Group 2 received Metformin (94.5mg/kg/day) +Ocimum sanctum (250 mg/kg/day), Group 3 received Metformin (94.5mg/kg/day) + Olmesartanmedoxomil(1.80 mg/kg/day), Group 4 received Metformin (94.5mg/kg/day) + Pitavastatin (0.18 mg/kg/day) and Group 5Metformin (94.5mg/kg/day) + Olmesartanmedoxomil (1.80 mg/kg/day) + Pitavastatin (0.18 mg/kg/day). The effects of Metformin alone and with Ocimum sanctum, Olmesartanmedoxomil, Pitavastatin and their combination on blood glucose and renal function test parameters were assessed. All groups showed decrease in fasting plasma glucose and glycosylated hemoglobin. Serum urea and creatinine were increased in the Control group. However, significant improvement in all the parameters studied were seen when Ocimum sanctum, Olmesartan or Pitavastatin were added. Histopathological examination of kidney showed mesangial proliferation, tubular swelling, thickened glomerular basement membrane,...
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Posted by admin on Sep 30, 2015 in |
Solubility is considered as the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response. Olmesartan medoxomil (OLM) is poorly soluble belongs to BCS class II. The drug is rapidly absorbed following oral administration, with a bioavailability approximately 26%. Liquisolid technique was used to enhance the aqueous solubility and dissolution rate to obtain faster on set of action, minimize the variability in absorption, and improve its oral bioavailability. The aim of the present study was to develop Olmesartan medoxomil liquisolid tablets using Quality by Design (QbD) approach to screen the effect of four formulation and process factors on the formulation. OLM liquisolid tablets were prepared by Liquisolid technique. Plackett-Burman (PB) design was used to screen the effect of four formulation and process factors to improve solubility and bioavailability. The liquisolid formulation were characterized by pre and post compression parameters, DSC, XRD, SEM, and in-vitro drug release. Excipients like Neusilin US2, Aerosil 200, PEG 400 and Primojel showed an influential effect on the selected...
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Posted by admin on Sep 30, 2015 in |
Aim of the present study was a comparative evaluation of antianxiety activity of three traditionally used medicinal plants — Argyreia speciosa (Roots), Caesalpinia digyna (Roots) and Sphaeranthus indicus (Flowers). The activity of various extracts (petroleum ether, chloroform, ethanol and water) of all the three plants was evaluated using elevated plus-maze model. The studies were conducted on lacca mice, and the test materials were administered per oral route. Results indicate that the ethanol extract of C. digyna roots exhibited maximum and significant dose dependent effect at 200 and 400 mg/kg on elevated plus-maze, the results were comparable to the standard antianxiety drug diazepam (2...
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Posted by admin on Sep 30, 2015 in |
The pharmacological activity of Withenia somnifera commonly called Ashwagandha, a herb having multi-medicinal properties, was investigated against carbofuran exposed hepatic anomalies in the air breathing fish Clarias batrachus. Fishes were exposed to 1 mg/L carbofuran for three weeks to induce the toxic effects. These fishes were then fed with Withenia somnifera root extract mixed pelleted feed @ 10% of the total feed ingredients for the next 6th and 8th week respectively. The histopathological examination of hepatic tissues was done on light microscopy and transmission electron microscopy. Major changes attributed to the hepatic cells after carbofuran treatment showed irregular shape of hepatic cells, increased sinusoidal spaces, rough endoplasmic reticulum, secretary granules, dilated mitochondrial cristae and presence of kupffer cells. Amoeboid nucleus with increased heterochromatin material, granular nucleoplasm and enlargement of nucleolus, were some of the prominent histopathological alteration in the liver tissue after carbofuran toxicity at transmission electron microscope (TEM) level. The histopathological examination of liver cell of carbofuran exposed fish followed by administration of W.somnifera root extract mixed pelleted...
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Posted by admin on Sep 30, 2015 in |
Objective: To evaluate hypoglycemic responses of Kasni (Cichorium intybus) seed preparations in combination with oral hypoglycemic agent in treatment of patients of newly diagnosed type2DM. Methods: Newly diagnosed 90 patients of type2DM, age 35-65years, of either sex were divided into 3 groups. Each group had 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In group A, only Glycomet SR once a day and in group B/C 6 grams crude seed powder or 50 ml decoction of crude seed powder twice a day in combination with Glycomet SR once in a day, was given for 90 days. FBG and PPBG were measured across 7 time periods and HbA1c levels were measured at zero and 90th day. Results: All the three groups shown a significant reduction in FBG and PPBG across the seven time periods. Post hoc TukeyHSD test shown that there was a significant difference between group A&B (p=0.027) and group A&C (p=0.000) for FBG and group A&B (p=0.019) and group...
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