Posted by admin on Apr 30, 2022 in |
To increase the efficacy of present anti-tumor agents, tumor-targeting can be proved as a successful approach for effective and safer drug delivery with less toxicity. According to researchers, for an effective tumor targeting module, disulfide linkage plays an important role in providing a medium for conjugating an anti-tumor drug with a carrier like vitamins and fatty acids. Disulfide bonds with unique chemical and biophysical properties can be used as cleavable linkers to deliver chemotherapeutic drugs. From the literature review, it has been observed that a disulfide bond acts as a self-immolating linker, which gets cleaved inside the body in the presence of intracellular glutathione; otherwise, it is stable in blood circulation. In this review, we discussed various strategies available in literature using disulfide as a linker in potent tumor targeting agents. Various successful conjugates are described here, which are currently under clinical...
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Posted by admin on Apr 30, 2022 in |
Moringa oleifera is an angiosperm plant that belongs to the family Moringaceae. It is also known as the Drumstick tree or Horseradish tree. Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and lipids are among the active phytoconstituents present. It is distributed throughout the world’s tropical and subtropical regions. Several studies show that various parts of the plant, such as seeds, flowers, bark, fruits, pods, gum and leaves, have antitumor, anti-inflammatory, wound healing, cholesterol-lowering, antioxidant, antidiabetic, antibacterial and antifungal, antimicrobial, antiulcer, antifibrotic, antifertility, antiurolithiatic, anticonvulsant, analgesic, local anesthetic, antiasthmatic and are used in the indigenous system of medicine to treat various diseases. This review aims to provide complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & Pharmacological...
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Posted by admin on Apr 30, 2022 in |
Bangladesh is gifted with the world’s largest bay, rich in untapped resources that are undeniably beneficial to human wellbeing and the national economy. However, the people of Bangladesh have not yet been capable of using the vast marine resources of the Bay of Bengal due to a lack of adequate funds and technological limitations. On the other hand, countries like Japan, China and Indonesia utilize their resources from the sea and develop therapeutic agents and molecules to produce efficient lifesaving drugs. Nowadays, marine habitat is considered one of the most resourceful areas for natural product research. Marine organisms possess enormous biological, biochemical, and biosynthetic potential. Likewise, bioactive compounds from marine microorganisms opened the door for novel therapeutic compounds discovery and development, i.e., anti-cancer, antibiotics, antifungals, and antiparasitic. Marine endophytes from algae and sponges are almost endless sources of novel compounds with numerous potential therapeutic applications due to their enormous diversity and intrinsic ability to create natural products of medical and pharmaceutical significance. There are nearly 257 pharmaceutical companies in...
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Posted by admin on Apr 30, 2022 in |
Inflammation is a host immune response initiated by the activation of inflammatory cascades resulting from any tissue injury. During the inflammatory response, multiple inflammatory mediators are released to restore the organ function and integrity by activating various inflammatory mediators. The presence of these molecules in the tumor microenvironment led to studies on the molecular pathways that are modulated during the inflammation to cancer transition. RB pathway is one such signaling pathway becoming more recognized in the microenvironments of pancreatitis and pancreatic ductal adenocarcinomas. RB1 is known to have multifunctional roles in the cellular growth and development processes, including apoptosis and autophagy. The RB protein in a dephosphorylated state negatively regulates the cell cycle at different checkpoints, thereby influencing the G1 to S phase progression. Besides its cell cycle activity, recent reports suggest that RB protein has a role in the pathogenesis of inflammation. The deregulation in the expression of RB protein is said to play an active role in stimulating the pro-inflammatory molecules, consequently resulting in inflammatory responses during...
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Posted by admin on Apr 30, 2022 in |
Perchlorate has been found in drinking water and surface waters in the United States of America, Canada, and India. It is primarily associated with the release of perchlorate from defense and military operations where rocket and satellite operation production takes place. Natural sources of perchlorate contain certain fertilizers and potash ores. Although it is a strong oxidant, perchlorate is very persistent in the environment. At high concentrations perchlorate can affect the thyroid gland by inhibiting the uptake of iodine. As per WHO gives a maximum tolerable daily intake of 0.01mg/kg body weight for perchlorate. Above 15 ppb intake of perchlorate, it changes normal to an abnormal condition of a living being. Perchlorate is measured in environmental samples primarily by ion chromatography. It can be removed from water by anion exchange or membrane filtration, biological and chemical processes. It remains stable for long times in water and soil in normal atmospheric...
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